ID   R9KF32_9FIRM            Unreviewed;       253 AA.
AC   R9KF32;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=Segregation and condensation protein A {ECO:0000256|HAMAP-Rule:MF_01805};
GN   Name=scpA {ECO:0000256|HAMAP-Rule:MF_01805};
GN   ORFNames=C810_03147 {ECO:0000313|EMBL:EOS44903.1};
OS   Lachnospiraceae bacterium A2.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=397290 {ECO:0000313|EMBL:EOS44903.1, ECO:0000313|Proteomes:UP000014150};
RN   [1] {ECO:0000313|EMBL:EOS44903.1, ECO:0000313|Proteomes:UP000014150}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A2 {ECO:0000313|EMBL:EOS44903.1,
RC   ECO:0000313|Proteomes:UP000014150};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium A2.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in chromosomal partition during cell division.
CC       May act via the formation of a condensin-like complex containing Smc
CC       and ScpB that pull DNA away from mid-cell into both cell halves.
CC       {ECO:0000256|HAMAP-Rule:MF_01805}.
CC   -!- SUBUNIT: Component of a cohesin-like complex composed of ScpA, ScpB and
CC       the Smc homodimer, in which ScpA and ScpB bind to the head domain of
CC       Smc. The presence of the three proteins is required for the association
CC       of the complex with DNA. {ECO:0000256|HAMAP-Rule:MF_01805}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01805}.
CC       Note=Associated with two foci at the outer edges of the nucleoid region
CC       in young cells, and at four foci within both cell halves in older
CC       cells. {ECO:0000256|HAMAP-Rule:MF_01805}.
CC   -!- SIMILARITY: Belongs to the ScpA family. {ECO:0000256|HAMAP-
CC       Rule:MF_01805}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOS44903.1}.
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DR   EMBL; ASSX01000017; EOS44903.1; -; Genomic_DNA.
DR   AlphaFoldDB; R9KF32; -.
DR   STRING; 397290.C810_03147; -.
DR   PATRIC; fig|397290.3.peg.3489; -.
DR   eggNOG; COG1354; Bacteria.
DR   HOGENOM; CLU_038686_3_0_9; -.
DR   OrthoDB; 9811016at2; -.
DR   Proteomes; UP000014150; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 6.10.250.2410; -; 1.
DR   Gene3D; 1.10.10.580; Structural maintenance of chromosome 1. Chain E; 1.
DR   HAMAP; MF_01805; ScpA; 1.
DR   InterPro; IPR003768; ScpA.
DR   InterPro; IPR023093; ScpA-like_C.
DR   PANTHER; PTHR33969; SEGREGATION AND CONDENSATION PROTEIN A; 1.
DR   PANTHER; PTHR33969:SF2; SEGREGATION AND CONDENSATION PROTEIN A; 1.
DR   Pfam; PF02616; SMC_ScpA; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|HAMAP-Rule:MF_01805};
KW   Cell division {ECO:0000256|HAMAP-Rule:MF_01805};
KW   Chromosome partition {ECO:0000256|ARBA:ARBA00022829, ECO:0000256|HAMAP-
KW   Rule:MF_01805}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01805};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014150}.
SQ   SEQUENCE   253 AA;  29817 MW;  AC1D839803F6A54C CRC64;
     MDLTVKLQVF EGPLDLLLHL LEKNKVNIYD IPIVEITKQY MEYINEMQRQ DLNVVSEFLV
     MAATLLDIKS KMLLPKEVSE EQEEDPRAEL VQKLLEYKMY KCMSYELKDR QIDAEKTLFK
     MPTIPEEVRK YEEPVDLQDL LSGLTLRKLN DIFKSIMRRQ ENKIDPIRSK FGKIEREEIS
     LEERMAYLEQ YAMAHRQFSF RGILEAQSGK MEVIVTFLSI LELIKTGKIH ILQEHIFDDI
     MIYANSGESQ MLA
//