ID   R9KG57_9FIRM            Unreviewed;       962 AA.
AC   R9KG57;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Penicillin-binding protein transpeptidase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=C810_02709 {ECO:0000313|EMBL:EOS45435.1};
OS   Lachnospiraceae bacterium A2.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=397290 {ECO:0000313|EMBL:EOS45435.1, ECO:0000313|Proteomes:UP000014150};
RN   [1] {ECO:0000313|EMBL:EOS45435.1, ECO:0000313|Proteomes:UP000014150}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A2 {ECO:0000313|EMBL:EOS45435.1,
RC   ECO:0000313|Proteomes:UP000014150};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium A2.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOS45435.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ASSX01000013; EOS45435.1; -; Genomic_DNA.
DR   AlphaFoldDB; R9KG57; -.
DR   STRING; 397290.C810_02709; -.
DR   PATRIC; fig|397290.3.peg.3000; -.
DR   eggNOG; COG0768; Bacteria.
DR   HOGENOM; CLU_009289_1_1_9; -.
DR   OrthoDB; 9757901at2; -.
DR   Proteomes; UP000014150; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014150};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          61..334
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          618..933
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   962 AA;  108016 MW;  A9864EC1C082454D CRC64;
     MFESIKNFSK KLISSRLFIL SLAMLGIFAI LMQRIFVLQI INGKEYMDNY TLRIQKERVT
     SGTRGSIYDR NGKLLAYSEL SYSVTIEDNG IYTSTSEKNR LMNEELNTVI HMVEEKGDAI
     TNTFGIQKDE TGAYGFVVTG KAQKRFLADV YGHTKIDDLK FNKKLGYNEG SATPEQVMEY
     LQDKFGIYVE GREYEDIKGR ELNFYTSEEA YKIMVLRYAI SQNSYQRYVL TTIAQNVSEE
     TVAVIKENSE ILQGIDIMED SIRKYVDSTY FSHIIGYTGK ISQTEYDELS KENDQYTLND
     VIGKSGIEQV MDQELQGTKG IEQFYADSVG RITEMIKKVD ASSGNNIYLS IDADLQKAVY
     QMLEQELAGI LYANIENIKE YDTSTGSASD IKIPIDDVFF ALINNNVIDI SHFSAEDAKL
     IEQQVYSAFL AKQDSVINEL RQQFSSGAPV PYEDLDSEQQ MYMSYILSML QKKEIFLSDK
     VDTEDEVYKA WKNDTISLCE YLRRAIAMDW IDITKFDTDS KYSDSTEIYD ALVTYITEEL
     KTDREFSKRI YKYMINQELV SGTQICLLLF EQGILQESEG DLTALQVGNL SAFQFMRDKI
     KNLQITPAQL ALDPCTASCV MINPRNGELL ACVTYPGYDT NRLANSVDSE YFASLQADLS
     IPQYNNATQQ QTAPGSTFKP VTAAAALTEG AVSVSEQIAT KGEFTEINPS PRCWIYPGST
     HGAITVSEAI RDSCNYFFYD LGYRMSSAGG VYNENKGIAT IQKYAALFGL DEKTGIEIPE
     NEPHIADEYP ITSSIGQSNH NFTTTQIARY LTAVASSGDI YKLTLLDKET TSDGTLVQEF
     KPEIIRKISE VSNVSWDAIH NGMRMVAEKH NSFKGFPIAV AGKTGTAQQI PTRANHALFI
     GYAPFANPEI AIATRIAYGY TSANATEVSK NILKYYFKLE GTDTLLDGQA EEIESTANGF
     TD
//