ID   R9M9L2_9FIRM            Unreviewed;      1158 AA.
AC   R9M9L2;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   RecName: Full=VWFA domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=C816_00373 {ECO:0000313|EMBL:EOS67341.1};
OS   Oscillibacter sp. 1-3.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Oscillibacter.
OX   NCBI_TaxID=1235797 {ECO:0000313|EMBL:EOS67341.1, ECO:0000313|Proteomes:UP000014108};
RN   [1] {ECO:0000313|EMBL:EOS67341.1, ECO:0000313|Proteomes:UP000014108}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1-3 {ECO:0000313|EMBL:EOS67341.1,
RC   ECO:0000313|Proteomes:UP000014108};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Oscillibacter bacterium 1-3.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall, S-layer
CC       {ECO:0000256|ARBA:ARBA00004237}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOS67341.1}.
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DR   EMBL; ASTC01000002; EOS67341.1; -; Genomic_DNA.
DR   RefSeq; WP_016320710.1; NZ_KE159703.1.
DR   AlphaFoldDB; R9M9L2; -.
DR   STRING; 1235797.C816_00373; -.
DR   PATRIC; fig|1235797.3.peg.423; -.
DR   eggNOG; COG2304; Bacteria.
DR   eggNOG; COG4099; Bacteria.
DR   HOGENOM; CLU_275552_0_0_9; -.
DR   OrthoDB; 1699243at2; -.
DR   Proteomes; UP000014108; Unassembled WGS sequence.
DR   GO; GO:0030115; C:S-layer; IEA:UniProtKB-SubCell.
DR   CDD; cd00198; vWFA; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR026906; LRR_5.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR001119; SLH_dom.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR43308:SF4; OUTER MEMBRANE PROTEIN ALPHA; 1.
DR   PANTHER; PTHR43308; OUTER MEMBRANE PROTEIN ALPHA-RELATED; 1.
DR   Pfam; PF13306; LRR_5; 1.
DR   Pfam; PF00395; SLH; 3.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51272; SLH; 3.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Cell wall {ECO:0000256|ARBA:ARBA00022601};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014108};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   S-layer {ECO:0000256|ARBA:ARBA00022601};
KW   Secreted {ECO:0000256|ARBA:ARBA00022601}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           32..1158
FT                   /note="VWFA domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004486431"
FT   DOMAIN          526..725
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          920..985
FT                   /note="SLH"
FT                   /evidence="ECO:0000259|PROSITE:PS51272"
FT   DOMAIN          986..1049
FT                   /note="SLH"
FT                   /evidence="ECO:0000259|PROSITE:PS51272"
FT   DOMAIN          1050..1107
FT                   /note="SLH"
FT                   /evidence="ECO:0000259|PROSITE:PS51272"
FT   REGION          465..500
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          899..927
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        474..500
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1158 AA;  125666 MW;  62146C17916F4106 CRC64;
     MSKKKISCRR GLSLFLALVM CAGLLQMPAL AAEHEHNSAG WACEKDELTC TILEHTHEEA
     CTSEEPLCGL EEHRHTDSCW SWNCAEPEPD EPPVQPGLSA QDELPVQDEL PVQDETLVQD
     EVPAPDEQPV QDVQTHVPSA YMDIGEMTPE GKVDRIIELM KEVPNQITEE NMDVYGPILE
     ECDQIMGGEY MENFGDAELD YAYEVVFEEF FAAIDKFVPA FNAYQELLAE QGNDGKALIE
     SRDEGIQLTY ADGVLTVSGE GMFTGLLINK VSYTSIKDYN SERPETAISE VVIEGENAEN
     PIKIGSSLFR DAGLTKLTAG NILAESMAFQ EAFVQGANIE LTDSTVCASV FTDCEGLGTV
     TLNHVTFHDN YGRFHLFSGS SIDRLVIRNM DRIGGYAFSG CKIKGEVDLS GVLYIGEHAF
     SGTGSPELKN ISEDAVVEYS DVFASQVENW SERVAGILQG KFRMDPPKTA EPIAPQGWTS
     SKTGKENSTE GQTSTQITEE ARWSDAELTE ADVLIQTYLA DVQQMDFIFV MDLSNSMSSR
     GGSDSRYSRF NEMQSKLLDV SGELLASGDE YDCQVAFVTF GGDSDPWYPL PWGESVITKG
     TMDFQDFTDE VDEAAAFITG SKVYDEYTDY GLGLNKALEL AESNQEKGRS TAVILISDGS
     PNKGDGKTEA EQIKALGVPV FGVLQSVPER EMENAEAAMR NICTNGFFFN GDDTEGFSKA
     VNDAVHNALR TCILTVDVNS SFTLNADSIT ASAGVADVSE DGTAITWTIV GKTFEKHTLS
     YKLRLNPENG AYPEGTFDTN AGSAHLLVSG LEVNEVETPQ LTRTQPVRSH TLTVRYQYSN
     GTQAAAAAVQ TVAEGASYSV TSPAISGFRA SIAVVSGTMG TEDLLFTVTY TSTGGGGGGG
     GGGGGGGTGG GGGGGGGGGG TGGTTIADTE VPLAGDLQLN REDHFAYIKG YEDGTVRPNN
     PLTRAQVATI FYRLLDEMSR TIYFQDTNEF TDVADTFWAN KAISTLTNAG IITGFQDGTF
     RPNAYITRAQ FAAIAARFDN VVPGLENPFS DVAEDYWARD LIAYAADRGW INGQGGKFRP
     LENITRVEAM DFINNVLERH VDEEGLLENA TTWSDVPVGD PNYYVVEEAT NSHDYTRRKE
     GELMENWTAL NEDPVWDE
//