ID RABL3_DANRE Reviewed; 233 AA.
AC Q6TNS7;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 125.
DE RecName: Full=Rab-like protein 3;
GN Name=rabl3; ORFNames=zgc:100876;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney marrow;
RX PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA Look A.T., Chen Z.;
RT "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP FUNCTION.
RX PubMed=31406347; DOI=10.1038/s41588-019-0475-y;
RA Nissim S., Leshchiner I., Mancias J.D., Greenblatt M.B., Maertens O.,
RA Cassa C.A., Rosenfeld J.A., Cox A.G., Hedgepeth J., Wucherpfennig J.I.,
RA Kim A.J., Henderson J.E., Gonyo P., Brandt A., Lorimer E., Unger B.,
RA Prokop J.W., Heidel J.R., Wang X.X., Ukaegbu C.I., Jennings B.C.,
RA Paulo J.A., Gableske S., Fierke C.A., Getz G., Sunyaev S.R.,
RA Wade Harper J., Cichowski K., Kimmelman A.C., Houvras Y., Syngal S.,
RA Williams C., Goessling W.;
RT "Mutations in RABL3 alter KRAS prenylation and are associated with
RT hereditary pancreatic cancer.";
RL Nat. Genet. 51:1308-1314(2019).
CC -!- FUNCTION: Required for KRAS signaling regulation and modulation of cell
CC proliferation (PubMed:31406347). Regulator of KRAS prenylation, and
CC probably prenylation of other small GTPases (By similarity). Required
CC for lymphocyte development and function (By similarity). Not required
CC for myeloid cell development (By similarity).
CC {ECO:0000250|UniProtKB:Q5HYI8, ECO:0000250|UniProtKB:Q9D4V7,
CC ECO:0000269|PubMed:31406347}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9D4V7}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; AY391440; AAQ91252.1; -; mRNA.
DR EMBL; BC078191; AAH78191.1; -; mRNA.
DR RefSeq; NP_991296.1; NM_205733.1.
DR AlphaFoldDB; Q6TNS7; -.
DR SMR; Q6TNS7; -.
DR STRING; 7955.ENSDARP00000115081; -.
DR PaxDb; 7955-ENSDARP00000115081; -.
DR DNASU; 403048; -.
DR GeneID; 403048; -.
DR KEGG; dre:403048; -.
DR AGR; ZFIN:ZDB-GENE-040808-11; -.
DR CTD; 285282; -.
DR ZFIN; ZDB-GENE-040808-11; rabl3.
DR eggNOG; ENOG502QT3S; Eukaryota.
DR HOGENOM; CLU_084875_1_0_1; -.
DR InParanoid; Q6TNS7; -.
DR OMA; THLICQQ; -.
DR OrthoDB; 205305at2759; -.
DR PhylomeDB; Q6TNS7; -.
DR PRO; PR:Q6TNS7; -.
DR Proteomes; UP000000437; Chromosome 9.
DR Bgee; ENSDARG00000040959; Expressed in testis and 28 other cell types or tissues.
DR ExpressionAtlas; Q6TNS7; baseline and differential.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; ISS:UniProtKB.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0030183; P:B cell differentiation; ISS:UniProtKB.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0001779; P:natural killer cell differentiation; ISS:UniProtKB.
DR GO; GO:1903059; P:regulation of protein lipidation; ISS:UniProtKB.
DR GO; GO:0046578; P:regulation of Ras protein signal transduction; ISS:UniProtKB.
DR GO; GO:0033077; P:T cell differentiation in thymus; ISS:UniProtKB.
DR CDD; cd04102; RabL3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24073; DRAB5-RELATED; 1.
DR PANTHER; PTHR24073:SF128; RAB-LIKE PROTEIN 3; 1.
DR Pfam; PF08477; Roc; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
PE 2: Evidence at transcript level;
KW GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..233
FT /note="Rab-like protein 3"
FT /id="PRO_0000312169"
FT REGION 1..233
FT /note="Small GTPase-like"
FT BINDING 16..21
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q9D4V7"
FT BINDING 148..150
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q9D4V7"
FT BINDING 179..180
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q9D4V7"
SQ SEQUENCE 233 AA; 26113 MW; F1490193C884C086 CRC64;
MASLDRVKVL VLGDSGVGKS SLVHLLCQNQ VLGNPSWTVG CSVDVRVHDY REGTPEEKAF
YIELWDVGGS VGSASSVKST RAVFYNSVNG IILVHDLTNK KSSQNLYRWS LEALSKDSSP
TGIIVSNGDY DREQFAENAV PLLLIGTKFD QIPENKRNDV LTRTAFLSED FNAEEINLDC
TNPRYLAAGS SNAVKLSRFF DKVIEKRYFT RDPSQMQSFT DRRRFNFKSL HSD
//
