ID RN145_XENTR Reviewed; 695 AA.
AC Q0IJ20;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=RING finger protein 145;
GN Name=rnf145;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; BC121248; AAI21249.1; -; mRNA.
DR RefSeq; NP_001072260.1; NM_001078792.1.
DR RefSeq; XP_012814664.1; XM_012959210.2.
DR RefSeq; XP_012814666.1; XM_012959212.2.
DR AlphaFoldDB; Q0IJ20; -.
DR SMR; Q0IJ20; -.
DR STRING; 8364.ENSXETP00000006638; -.
DR PaxDb; 8364-ENSXETP00000035727; -.
DR Ensembl; ENSXETT00000035727; ENSXETP00000035727; ENSXETG00000016361.
DR GeneID; 779713; -.
DR KEGG; xtr:779713; -.
DR AGR; Xenbase:XB-GENE-979193; -.
DR CTD; 153830; -.
DR Xenbase; XB-GENE-979193; rnf145.
DR eggNOG; KOG0802; Eukaryota.
DR HOGENOM; CLU_016467_1_0_1; -.
DR InParanoid; Q0IJ20; -.
DR OMA; ARDMWPL; -.
DR OrthoDB; 2912447at2759; -.
DR PhylomeDB; Q0IJ20; -.
DR TreeFam; TF318635; -.
DR Proteomes; UP000008143; Chromosome 3.
DR Bgee; ENSXETG00000016361; Expressed in 4-cell stage embryo and 12 other cell types or tissues.
DR ExpressionAtlas; Q0IJ20; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd16684; RING-H2_RNF145; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047823; RNF145_RING-H2.
DR InterPro; IPR025754; TRC8_N_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR011016; Znf_RING-CH.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22763:SF167; RING FINGER PROTEIN 145; 1.
DR PANTHER; PTHR22763; RING ZINC FINGER PROTEIN; 1.
DR Pfam; PF13705; TRC8_N; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00744; RINGv; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Membrane; Metal-binding; Reference proteome; Transmembrane;
KW Transmembrane helix; Zinc; Zinc-finger.
FT CHAIN 1..695
FT /note="RING finger protein 145"
FT /id="PRO_0000294028"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 482..502
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ZN_FING 537..575
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 585..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 695 AA; 78567 MW; C7B7FF624F3313A9 CRC64;
MGAKEKLEAM LNVALRVPSI MLLDVLYRWD VSSFFKQIQR SSLNNNPLFQ YKYLALNMHY
VGYILSVVLL TLPRQHLAKL YLYFVAALLL YAGHQISRDY VRSELESGYE GPMHIEPLSM
NRFITALVGQ LVVCTLCSCV MKTKQIWLFS AHMLPLLARL CLVPIETIVV INKFAMIFTG
LEVLYFLASN LLVPFNLAKS AYRELAQVVE VYGLLALGMS LWNQLVVPVL FMVFWLVLFA
LQIYTYFSTR DQPTSRERLL FLFLTSIAEC CSTPYSLLGL VFTVSFVALG VLTLCKFYLQ
GYRAFMNDPA MNRGMTEGVT LLILAVQTGL IELQVVHRAF LLSIILFIVV ASILQSMLEI
ADPIVLALGA SRDKSLWKHF RAVSLCLFLL VFPSYMAYMI CQFFHMDFWL LIIISSSILT
SLQVLGTLFI YVLFMIEEFR KEPVENMDDV IYYVNGTYRL LEFLVALCVV AYGVSETVFG
EWTVMGSMII FIHSYYNVWL RAQLGWKSFL LRRDAVNKIK SLPVATKEQL EQHNDICSIC
YQDMNSAVIT PCSHFFHPGC LKKWLYVQET CPLCHCQLKS LSQQATGESG SSTNPVSEQS
ATNPPLGPVS RAEVTTEPLA AVPTRSALEQ EPTMDIKVSG SVEKRIGELE AHFSQGEANL
NSNEVLQRLQ AKGEANPEDL NVKALPPECE HCAEI
//
