ID S0E7G1_GIBF5 Unreviewed; 708 AA.
AC S0E7G1;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Related to ferric reductase Fre2p {ECO:0000313|EMBL:CCT70575.1};
GN ORFNames=FFUJ_06559 {ECO:0000313|EMBL:CCT70575.1};
OS Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae
OS and foot rot disease fungus) (Fusarium fujikuroi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=1279085 {ECO:0000313|EMBL:CCT70575.1, ECO:0000313|Proteomes:UP000016800};
RN [1] {ECO:0000313|Proteomes:UP000016800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 195.34 / IMI 58289 / NRRL A-6831
RC {ECO:0000313|Proteomes:UP000016800};
RX PubMed=23825955; DOI=10.1371/journal.ppat.1003475;
RA Wiemann P., Sieber C.M., von Bargen K.W., Studt L., Niehaus E.M.,
RA Espino J.J., Huss K., Michielse C.B., Albermann S., Wagner D.,
RA Bergner S.V., Connolly L.R., Fischer A., Reuter G., Kleigrewe K., Bald T.,
RA Wingfield B.D., Ophir R., Freeman S., Hippler M., Smith K.M., Brown D.W.,
RA Proctor R.H., Munsterkotter M., Freitag M., Humpf H.U., Guldener U.,
RA Tudzynski B.;
RT "Deciphering the cryptic genome: genome-wide analyses of the rice pathogen
RT Fusarium fujikuroi reveal complex regulation of secondary metabolism and
RT novel metabolites.";
RL PLoS Pathog. 9:E1003475-E1003475(2013).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ferric reductase (FRE) family.
CC {ECO:0000256|ARBA:ARBA00006278}.
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DR EMBL; HF679028; CCT70575.1; -; Genomic_DNA.
DR AlphaFoldDB; S0E7G1; -.
DR STRING; 1279085.S0E7G1; -.
DR EnsemblFungi; CCT70575; CCT70575; FFUJ_06559.
DR VEuPathDB; FungiDB:FFUJ_06559; -.
DR HOGENOM; CLU_010365_1_0_1; -.
DR OrthoDB; 2049651at2759; -.
DR Proteomes; UP000016800; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000293; F:ferric-chelate reductase activity; IEA:UniProt.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR CDD; cd06186; NOX_Duox_like_FAD_NADP; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR InterPro; IPR013121; Fe_red_NAD-bd_6.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR PANTHER; PTHR32361:SF9; FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED; 1.
DR PANTHER; PTHR32361; FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT; 1.
DR Pfam; PF01794; Ferric_reduct; 1.
DR Pfam; PF08030; NAD_binding_6; 1.
DR SFLD; SFLDS00052; Ferric_Reductase_Domain; 1.
DR SFLD; SFLDG01168; Ferric_reductase_subgroup_(FRE; 1.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR PROSITE; PS51384; FAD_FR; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000016800};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023065}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..708
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004484939"
FT TRANSMEM 167..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 400..560
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 708 AA; 80757 MW; 148ED78674296A91 CRC64;
MKFAASLGAL LVNLSLWTLS LAAEDRSPER VCYDACFACL KPVHFDDVLR NQTGFTKTCY
SPKAILSLYL CLDVYCTPGA VEVGLGSYNE TCREQAHIVL PPFDVISNYT AEDVKGVRRF
EQNETDKGVL FREVVVPSEH WFGIWWDTLD SVAYTYTYHD VYGRAMITFW IVVVTIGVLN
HAILHIANLQ MVRNYSPRSG GRFWNFYNWA LNRITVPAFM GNRCAQKVGW GTVPPQVQSW
TLFAFLLLNI ALSILGYRIV PVNMYFPSTA KQILRYVSDR TGIISWANFP VIWLFGMRNN
LLMWLTGWDF GTYNNFHRWV ARIATLQAVV HSIGYTWLIV LEGGWEYYLF WWNYMFWWVG
EVATIVMSLL VGASFYWIRR QHHVSIFQGE YDVFFWVPCF IWVGDRVIRA LRIAAFSPKL
WDTWATSIYH PASNIVRLVV PWSSSLYKPA PGTFYYIHVL NGPRCWESHP FTVAMVTDEG
QRGSKLLGEQ VPLLDGTVAE QSSDPVDSQD ILSDSRTMTF LIRPYDGFTS RLRDAASTVW
PKNVPQRVLV DGPYGHTRPL HLFDNVTFIV GGSGIVVPLS YLQRLTGPTA PRSVKIHWAV
REPAFALDVL QTDIADSLGS TNLSIEIHLT THTPQDELSE WPSQVTLRRG RIDASDVVRR
RSEEAMGESL AIIACGPAQM ADDARKTVAD LLRNGVMRVE YFEESFQW
//
