ID   S1P5T6_ECOLX            Unreviewed;       248 AA.
AC   S1P5T6;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   RecName: Full=DnaA regulatory inactivator Hda {ECO:0000256|HAMAP-Rule:MF_01158};
GN   Name=hda {ECO:0000256|HAMAP-Rule:MF_01158};
GN   ORFNames=A13A_02662 {ECO:0000313|EMBL:EOW96530.1};
OS   Escherichia coli KTE182.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=1181728 {ECO:0000313|EMBL:EOW96530.1, ECO:0000313|Proteomes:UP000014179};
RN   [1] {ECO:0000313|EMBL:EOW96530.1, ECO:0000313|Proteomes:UP000014179}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KTE182 {ECO:0000313|EMBL:EOW96530.1,
RC   ECO:0000313|Proteomes:UP000014179};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Feldgarden M., Nielsen K.L., Frimodt-Moller N., Andersen P.S., Walker B.,
RA   Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A.,
RA   Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA   Larimer J., McCowan C., Murphy C., Neiman D., Pearson M., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Escherichia coli KTE182.";
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the interaction of DNA replication inititator
CC       protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN).
CC       Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive
CC       for reinititation, a process called regulatory inhibition of DnaA or
CC       RIDA. {ECO:0000256|HAMAP-Rule:MF_01158}.
CC   -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms the
CC       RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA, ADP-Hda and
CC       the DNA-loaded beta sliding clamp (dnaN). {ECO:0000256|HAMAP-
CC       Rule:MF_01158}.
CC   -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01158}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOW96530.1}.
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DR   EMBL; ASUG01000039; EOW96530.1; -; Genomic_DNA.
DR   AlphaFoldDB; S1P5T6; -.
DR   SMR; S1P5T6; -.
DR   PATRIC; fig|1181728.3.peg.2735; -.
DR   HOGENOM; CLU_072265_1_1_6; -.
DR   Proteomes; UP000014179; Unassembled WGS sequence.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   GO; GO:0032297; P:negative regulation of DNA-templated DNA replication initiation; IEA:InterPro.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_01158; Hda; 1.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR017788; Hda.
DR   InterPro; IPR022864; Hda_Enterobact.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR03420; DnaA_homol_Hda; 1.
DR   PANTHER; PTHR30050; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR   PANTHER; PTHR30050:SF5; DNAA REGULATORY INACTIVATOR HDA; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   PRINTS; PR00051; DNAA.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_01158};
KW   DNA replication inhibitor {ECO:0000256|ARBA:ARBA00022880,
KW   ECO:0000256|HAMAP-Rule:MF_01158}.
FT   DOMAIN          31..226
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /evidence="ECO:0000259|Pfam:PF00308"
SQ   SEQUENCE   248 AA;  28370 MW;  A8FDFB3C5813681E CRC64;
     MVNFSRFCEI LVEVSLNTPA QLSLPLYLPD DETFASFWPG DNSSLLAALQ NVLRQEHSGY
     IYLWAREGAG RSHLLHAACA ELSQRGDAVG YVPLDKRTWF VPEVLDGMEH LSLVCIDNIE
     CIAGDELWEM AIFDLYNRIL ESGKTRLLIT GDRPPRQLNL GLPDLASRLD WGQIYKLQPL
     SDEDKLQALQ LRARLRGFEL PEDVGRFLLK RLDREMRTLF MTLDQLDRAS ITAQRKLTIP
     FVKEILKL
//