ID S2F4H1_9PSED Unreviewed; 1116 AA.
AC S2F4H1;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Small-conductance mechanosensitive channel {ECO:0000313|EMBL:EPA98316.1};
GN ORFNames=PG5_12140 {ECO:0000313|EMBL:EPA98316.1};
OS Pseudomonas sp. G5(2012).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=1268068 {ECO:0000313|EMBL:EPA98316.1, ECO:0000313|Proteomes:UP000014290};
RN [1] {ECO:0000313|EMBL:EPA98316.1, ECO:0000313|Proteomes:UP000014290}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G5(2012) {ECO:0000313|Proteomes:UP000014290};
RA Park S., Lee J.-H., Cho Y.-J., Chun J., Hur H.-G.;
RT "Draft Genome Sequence of Pseudomonas sp. Strain G5, Isolated from a
RT Traditional Indigo Fermentation Dye Vat.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPA98316.1}.
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DR EMBL; APIO01000014; EPA98316.1; -; Genomic_DNA.
DR RefSeq; WP_020796196.1; NZ_APIO01000014.1.
DR AlphaFoldDB; S2F4H1; -.
DR PATRIC; fig|1268068.3.peg.1153; -.
DR eggNOG; COG3264; Bacteria.
DR Proteomes; UP000014290; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR006686; MscS_channel_CS.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR025692; MscS_IM_dom1.
DR InterPro; IPR024393; MscS_porin.
DR PANTHER; PTHR30347:SF8; MECHANOSENSITIVE CHANNEL MSCK; 1.
DR PANTHER; PTHR30347; POTASSIUM CHANNEL RELATED; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR Pfam; PF12795; MscS_porin; 1.
DR Pfam; PF12794; MscS_TM; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS01246; UPF0003; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1116
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004496589"
FT TRANSMEM 491..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 612..631
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 678..700
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 712..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 779..802
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 822..843
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 864..885
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 897..925
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..270
FT /note="Mechanosensitive ion channel MscS porin"
FT /evidence="ECO:0000259|Pfam:PF12795"
FT DOMAIN 491..809
FT /note="Mechanosensitive ion channel inner membrane"
FT /evidence="ECO:0000259|Pfam:PF12794"
FT DOMAIN 870..911
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 913..978
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 986..1069
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT COILED 221..251
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1116 AA; 124654 MW; FE98CBA54F762886 CRC64;
MSSLRTFFVM VLLGLSLSVG TVQAAEPPTR ESVQASLDKI ADRKLPEADQ KALQSVLQST
LTQLNNQRDY EQKLVELKQQ LASAPKLTIE NQRELARLKA SSVVPVAQRF AKESIQQLEQ
LLTERSTQQS DLQKALGDAN SLIITAQTRP ERAQGEISAS QTRIQQINNI LKAGKDAGKT
LSAEQRDQLN AELMALNALI PLRRQELASN TQLQDLGNSQ HDLLTEKSDR LDQEIQELQN
LINQKRLAQS QETVTQQSIE AQKAGGSSLL AVESTANLKL SDYLLKSTDR LNEVTQKNLQ
TKQQLDSLTQ SDSALDEQIN VLKGSLLLSK ILYKQKQALP RLRVDRDLAD QIADIRLYQF
EVSQQRELLS NPASYVDNLL STQPPEQVTP QLRKSLLELA TTRADLLERL NRELSAVLNE
SITLQLNQKQ LLSTAQSLRA TLDEQMFWIP SNKPLDVEWF STVPERLSRQ VDTLPWASSL
SELVDGLTQR PLLFLPLALL IGALLWRRKQ LYARLNKVHQ DIGHFKRDSQ WHTPQAILIN
ILLAMPVSLA LALCGLALQI DARGQNASMG AALLQMAGAW LVFYTAYRIL APGGVAELHF
RWEKPQVEFL RGWVRRLGMV VMALVTVVAV AELQPAALAD DVLGMPVVLI CYALMTWLLS
RLLISSPTHE NASLFRKVLG ILFTALPIAL FVAVCFGYYY TALKLSDRLI NTLYLLMFWL
VIEATFVRGL SVAARRLAYQ RALAKRQAAK EAGDGEAIIE EPTLDIEKVN EQSLRLIRLA
LLGGFIAALY WVWADLITVF SYLDNITLYE YTSGTGANMS MVPISIGDML GALIIIGITF
ALARNLPGLL EVFVLSKLNL AQGSAYATTT LLSYLIAGIG FVSTLSTLGV SWDKLQWLVA
ALSVGLGFGM QEIFANFISG IMILFERPVR IGDTITIGNL SGTVSKIRIR ATTITDFDRK
DIIVPNKTFI TGQLINWSLT DTITRVTLKL GVDYGSDLDL VKELLLKAAR ENPRVLKEPE
PHVYFLNFGE STLDHELRMH VRDLGDRNPV LDEVNRFINR EFKKQHINIS FRQMEVYLKN
LHGQEYKMVP IEPEAKTIVP LVDGKPVQEP PSAKLD
//
