ID   S2J028_MUCC1            Unreviewed;       804 AA.
AC   S2J028;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=Cullin family profile domain-containing protein {ECO:0000259|PROSITE:PS50069};
GN   ORFNames=HMPREF1544_11769 {ECO:0000313|EMBL:EPB81507.1};
OS   Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS   agent) (Calyptromyces circinelloides).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX   NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB81507.1, ECO:0000313|Proteomes:UP000014254};
RN   [1] {ECO:0000313|Proteomes:UP000014254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   EMBL; KE124169; EPB81507.1; -; Genomic_DNA.
DR   AlphaFoldDB; S2J028; -.
DR   STRING; 1220926.S2J028; -.
DR   VEuPathDB; FungiDB:HMPREF1544_11769; -.
DR   eggNOG; KOG2167; Eukaryota.
DR   InParanoid; S2J028; -.
DR   OMA; WCVENEY; -.
DR   OrthoDB; 5474206at2759; -.
DR   Proteomes; UP000014254; Unassembled WGS sequence.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF126; CULLIN 4, ISOFORM A; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000014254}.
FT   DOMAIN          444..673
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..51
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   804 AA;  92613 MW;  69792CD7307BD401 CRC64;
     MSKPTPKAGL KKRKMGSSPV DPTQRRLDRF LSTSSPSQSP SPSPSSYLVK NEPMQLDSVV
     PNIKKNPMLG TYRQQIILPK ITIADADPER QAELTDANFE NCWTMPKKLI LSIFSTDNFN
     RVNYITASQI SMGLCRFGKS EQVYNSLKQE IENHVQDIKK SLMSKPLNSN LLSRLNVHWD
     TFCQQLTIIR TVFMELDRYY ILPNTKYKSI SQLGKDLFSE LIMEKDNFLH VVIAEVIHQI
     KVERDGSKIN IRLIQDILRM LTDQSYYKSE FEPRFLESTN LYYKEEANRR IGYGTIPEYI
     YHAAGRRTQE SEERVKNYLN PDTKQALISV VVDRLVYAKT ETIIENGFEA MMDTDMYEPL
     KIFYELLLQS PKMNLLRSAF GAYVKEEGMK IIKDPKSDPT MITSLLIFKR KIDNILKSCF
     NDDVTFVNAL KESFEQFINT RGNKPAELLA KHLDSKLKIP VKRQRFQEIV DTVSLDYILT
     LFRYIQTKDA FEAYFKRFLA KRLLMDRSAS SELENHVLVN LKAECGPEFT KNLESMFTDV
     QISADLTNEF KEFKKEKSRL PMTVKVIAQA TWPSYSLLDI KLPANMMASQ KLFENFYVNK
     FNGRKLVWQN RLSSCSIVAN YPKGRKEIVA SLAQAVILFI FNDANKKTLT FSKIQTITAL
     AKNDLIGLLT SLCTGPYKLI LNTSSTSDKD TVTPTDSFAY NADFESANQK VRIPPATSIE
     PTKDEEKDVE KKVHISRQHQ LEAAIVRIMK AKKTSTHNAL VDELFKELKY PVQADDIKKR
     IESLIDRDYI IRDPEDHSSY VYQS
//