ID   S2JE34_MUCC1            Unreviewed;      1248 AA.
AC   S2JE34;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN   ORFNames=HMPREF1544_06435 {ECO:0000313|EMBL:EPB86737.1};
OS   Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS   agent) (Calyptromyces circinelloides).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX   NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB86737.1, ECO:0000313|Proteomes:UP000014254};
RN   [1] {ECO:0000313|Proteomes:UP000014254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC       (CIA) complex, a multiprotein complex that mediates the incorporation
CC       of iron-sulfur cluster into apoproteins specifically involved in DNA
CC       metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC       adapter between early-acting CIA components and a subset of cellular
CC       target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU367072}.
CC   -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC       {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR   EMBL; KE123982; EPB86737.1; -; Genomic_DNA.
DR   AlphaFoldDB; S2JE34; -.
DR   STRING; 1220926.S2JE34; -.
DR   VEuPathDB; FungiDB:HMPREF1544_06435; -.
DR   eggNOG; KOG1967; Eukaryota.
DR   InParanoid; S2JE34; -.
DR   OMA; AKDDCHA; -.
DR   OrthoDB; 38995at2759; -.
DR   Proteomes; UP000014254; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039920; MET18/MMS19.
DR   InterPro; IPR024687; MMS19_C.
DR   InterPro; IPR029240; MMS19_N.
DR   PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR   PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR   Pfam; PF12460; MMS19_C; 1.
DR   Pfam; PF14500; MMS19_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|RuleBase:RU367072};
KW   DNA repair {ECO:0000256|RuleBase:RU367072};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014254};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          44..299
FT                   /note="MMS19 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14500"
FT   DOMAIN          542..974
FT                   /note="MMS19 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12460"
SQ   SEQUENCE   1248 AA;  139647 MW;  8EBCA054254CDD54 CRC64;
     MDISQKLTEW LTSEKSEVEP SLLAYVLLYS TKNLTGLVDV LKCLVSFWEE GDAACRTKCI
     ELLAQVVTPS QSALDSATNN AIIQFISGRL DDSVLVPRCV DIFSILIQSD SISSTDALQL
     CNAIFTHIKV KKLPQQSRYK ILIILGKTLE KYASETQRSK INFIGGFINC MDGEKDPRNL
     MVAFELVRAI IDRFDISRHI EDLFDVVFCY FPISFAAPAN DPFGITTEDL KDSLRRCLAA
     TPYFAYYATP LLIEKLLSTT GSAKKDAMET IGLCAPAYGA HAILPHAQDL FDALVREVYQ
     EADAAMVQVA LDTIHSVVAT LGTGISIANI RDPVEKAIDS LLHKCVEELK EPELKNARSA
     AYILRAAASA SDPACTSVTH TALPIICQQY KTTDPAIRRK AILDILTELL VASKKLYGSV
     EDVGYDRDFQ TPLLMYKQQI LQVFMFSLNT TDTVLKQASL KGIHEMVLMK QFLKGEEVNM
     TVDQLTGQLM QEDAPLRALS LSTLGVVSKL YPMILGQRTF PALLECLPSL DNPIISESYR
     DTLDEIQVLG AHPAVFKIII QSILEKVDFA CRHIGKNNIN FVHDMALTLL KIYKAASKDC
     EIVVYGRNAL LPTVLIECMK SVSGNEGNWY LDDTLIEMFA MIAAITTRLS SSSEQQTSIN
     DMFKLFVQGD VSPLDQNIQI DSLPIFGHIT STSSAIDITL LFTAIISNCC KTVQLPIPSL
     SGFMTNLIQT ATQTPSEMRK LALSKIAASI INKWLNDELL SHVKNLVSES ILPTLETATD
     TDNKRSTFVI LVWIIKALII RGHRYGFELL DSVIKQCGSP ELGKYAADSF ITLLHQDELI
     LNKSSHAIVS ILFKQRVFTH CFRKLMDGAE SVDVRQPELQ VNYLLALIHV LQNIPSQVAT
     NELHRLMLPI IVALSSHDSN LIKSTLTVAQ DIVPNAQDLV VQHLGSFIHA LLRLTRFHSA
     NVRIIALECL TSIALKGKPD VLRPFKPSVV KELSTALDDK KRLVRKNAVN ALPVQHAFVP
     SSPSHENSID AQEYTVYSSV IEYYENLIDA TLSSESEELL INLIHLPKES MKNILTLQAE
     SMGFKTVSDK QLNKMPALVG KHIQAMNTHV YESIEPIVNS HWSAVWDKKL LYADDQEEIL
     SFLSSLNGFV AKKLVDQVDN YNLLEKVKQD MVALYDREQE QSWFRWLSNT KKIVLSLEDT
     VTEEDANFLR QHITDIRTSL MMELHIQFMD FFTRIQSDII DQFVMYED
//