ID   S2JEV7_MUCC1            Unreviewed;       883 AA.
AC   S2JEV7;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   08-NOV-2023, entry version 40.
DE   RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN   ORFNames=HMPREF1544_04851 {ECO:0000313|EMBL:EPB88384.1};
OS   Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS   agent) (Calyptromyces circinelloides).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX   NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB88384.1, ECO:0000313|Proteomes:UP000014254};
RN   [1] {ECO:0000313|Proteomes:UP000014254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KE123952; EPB88384.1; -; Genomic_DNA.
DR   AlphaFoldDB; S2JEV7; -.
DR   STRING; 1220926.S2JEV7; -.
DR   VEuPathDB; FungiDB:HMPREF1544_04851; -.
DR   eggNOG; KOG4305; Eukaryota.
DR   InParanoid; S2JEV7; -.
DR   OrthoDB; 1359868at2759; -.
DR   Proteomes; UP000014254; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041675; PH_5.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR   PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF15405; PH_5; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000014254}.
FT   DOMAIN          525..712
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          255..276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   883 AA;  101153 MW;  6C650A42F4B1D451 CRC64;
     MSKLNEIAIV EEDHCSPYHH QGAYKNDFSL PSPASNYSDA EISPDIENSY IQQNLPVRRQ
     SLIVYHDKMR NENMLKQQQS DPQSPKRHSS LNFPTTVAAE EMTEERKSRL YNSKSLNAIH
     NKSEDYRKSR MPNPPLTIEI THPESSASTS TLSCASNSPF ELSMDTLFEE DRSPLSPSQQ
     AQVQQQLPPR QSIPRFIGLL RPSKSETIYN NKKNDKLTTP VDLHPSSPLS TSWNDNMSQP
     LSRLRNVFSR LQTNTASVNP NNTPNTIKPS TSTSKRMSMQ VMEAKKKKRI STAIKGGAGD
     NKSRKKKTAA NIYTALLSHV SKEFLKRMQI STIAFKDGIQ YHDVFHGIEA VNCILDILCT
     SDRNLALLVG RALESQGLFH HVNYDYRLRD AESELYQFQY LQSQQDTPPT YGGRPPIPSQ
     FTTNNSTKLL SLKKSNRRNG TPSVCETLPI NGVFSVLTDC YSPTCTRKSP CYSISCPRMM
     AKKNKSIQRP LSSQFLRTEQ EQLRSLWRHS VPRNIVMGTN DIEQKRQECI YELIYTEEDF
     TRDMHYVQDF WIEPLLNSDI IPIDRRHQFI TDVFWNLADI ERISMALSRD LTARQDKHSV
     IPCIGDILLE HVKGFEPFVI YGAHQIIGKH KFELEKKRNT KFLQFAQTLE RQPESRRLEL
     NGYLTKPTSR LGRYNLLLTT IHHLTPKDHQ DYETIPKVID MITEFMVQLN KQVGLSDNAF
     HLELISSRII VNKGSFDLNL LDPKRQLLMR GKMKRANHTS KSLYSAATSP ITENTNIDIQ
     LFLFDNYLVF CKIKNQDGID YYKIYQKPIP LASLTAFIPF HNALKSKTVS TLPDTNHHSS
     VLGYPITFAN TADNLSSIPL IASTESTRKL WLDKIKEEQE KLK
//