ID   S2JQ13_MUCC1            Unreviewed;       762 AA.
AC   S2JQ13;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Patatin-like phospholipase domain-containing protein {ECO:0000256|RuleBase:RU362055};
DE            EC=3.1.1.- {ECO:0000256|RuleBase:RU362055};
GN   ORFNames=HMPREF1544_01123 {ECO:0000313|EMBL:EPB92059.1};
OS   Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS   agent) (Calyptromyces circinelloides).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX   NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB92059.1, ECO:0000313|Proteomes:UP000014254};
RN   [1] {ECO:0000313|Proteomes:UP000014254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Lipid hydrolase. {ECO:0000256|RuleBase:RU362055}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362055}; Single-
CC       pass membrane protein {ECO:0000256|RuleBase:RU362055}.
CC   -!- SIMILARITY: Belongs to the PLPL family. {ECO:0000256|ARBA:ARBA00006104,
CC       ECO:0000256|RuleBase:RU362055}.
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DR   EMBL; KE123903; EPB92059.1; -; Genomic_DNA.
DR   AlphaFoldDB; S2JQ13; -.
DR   STRING; 1220926.S2JQ13; -.
DR   VEuPathDB; FungiDB:HMPREF1544_01123; -.
DR   eggNOG; KOG2214; Eukaryota.
DR   InParanoid; S2JQ13; -.
DR   OMA; PRTRFMD; -.
DR   OrthoDB; 154387at2759; -.
DR   Proteomes; UP000014254; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006641; P:triglyceride metabolic process; IEA:UniProt.
DR   CDD; cd07232; Pat_PLPL; 1.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 2.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR002641; PNPLA_dom.
DR   InterPro; IPR021771; Triacylglycerol_lipase_N.
DR   PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR   PANTHER; PTHR14226:SF66; TRIACYLGLYCEROL LIPASE PTL2; 1.
DR   Pfam; PF11815; DUF3336; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU362055};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963,
KW   ECO:0000256|RuleBase:RU362055};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW   ECO:0000256|RuleBase:RU362055}; Membrane {ECO:0000256|RuleBase:RU362055};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014254};
KW   Transmembrane {ECO:0000256|RuleBase:RU362055};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362055}.
FT   TRANSMEM        114..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362055"
FT   DOMAIN          295..487
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
FT   REGION          83..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          721..762
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        724..740
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   762 AA;  86728 MW;  606BD921EAF6897D CRC64;
     MAKNAEKAIK KTTNKIARGA DNFGTKRLDD KNYKIENPLD VEYVNEVHVS DFMKALAYDP
     VKGVDTSNAE HIAAWTDALP VRSTSSSSKN QTKPSKRKLR EQEAAKPKGI SHSLLQYPLI
     IIISVIMFVE LVAYISLRQI VRIWENVFSW RGKKRALRNN LRASKTYKEW CESADALDNY
     MHKDEWKKTI PFAYYDYRLL QKVVKHLKIY RQGDTVEDAT KLMDVLYVCL KQNFAGIENA
     KLYSNTYLGT KALIEEYVEE VTRSIETLAS NKHISNDEKK LAFKLYSKNY GRTAFCLSGG
     AGFGYYHLGV IRALLDRGLL PSIITGTSAG SLMGAIVCTR TDEELDQILN PDLSSRIRIC
     RDSWPTKLYR FVTQGSLFDA EQWCREAMWF CKGSLTFKEA YERTGRIFNV SVIPYDPHSP
     PKLLNYLTAP DCVIWSAVLA SAAIPGILNP VVLMQKKGNS THLIPYNYGH KFKDGSLSTD
     IPTLALNTQF NVNYTIVSQV NPHVHVFFYA NQGSPGRPVT HLQGRGWRGG FLASTIEQML
     KLDLAKWLKV LRSLKLLPNV HDQDWSSVWL QKFDGNVTIL PKSDLSDWLY TIADPDVERL
     KKLMNIGQIR TWPKVSMISN RMRIEASIEK VRRLLRANSN NKNNRAGRFN SLSDAETEKL
     TQHMEAHDAI QYANNSDAGS GDELAFLSRR RVSMPDGSFQ HLQDKDFFKE QNRRRKFMAQ
     FLDSPKEGNN STQSSVLFDS HSDDSDSHSP PPSSPEDYTL RH
//