ID S2K6C6_MUCC1 Unreviewed; 1034 AA.
AC S2K6C6;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF1544_02177 {ECO:0000313|EMBL:EPB90923.1};
OS Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS agent) (Calyptromyces circinelloides).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB90923.1, ECO:0000313|Proteomes:UP000014254};
RN [1] {ECO:0000313|Proteomes:UP000014254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG The Broad Institute Genomics Platform;
RA Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KE123914; EPB90923.1; -; Genomic_DNA.
DR AlphaFoldDB; S2K6C6; -.
DR STRING; 1220926.S2K6C6; -.
DR VEuPathDB; FungiDB:HMPREF1544_02177; -.
DR eggNOG; KOG4305; Eukaryota.
DR InParanoid; S2K6C6; -.
DR OMA; YTELTHC; -.
DR OrthoDB; 1367119at2759; -.
DR Proteomes; UP000014254; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000014254}.
FT DOMAIN 297..484
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 692..1008
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 165..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1034 AA; 118648 MW; D27A958752394AAC CRC64;
MTALHQDNAN NRLLSAIPEN KQQGAFKRYN NSTPATTGYY RAFLSSIAFE LKRRIITNDR
IKNGIEYSNV FDGKEAIDKL KEILGTTDRS LALRVGRALE AQRFFHDVNY ENRLIDDIIE
IYQFNQVLFH SNNNRSASTT STTSSNSSSG GNSFSVTSTI IGNYASEDED DDDDDHNSLH
TDTTAATSTH SQSYRQQDQQ HHSSSNSSSS NSSNNLLLPN GIYTELTHCY TPTCDNIHPC
YSYTCPKRER LRKRPHSVDT REKRVTAYIY EVEKHQQLWS QTIDDYIVLS TPANERKRQE
TIFELIYTEE NFLNDLDYVI KMWMEPLKNS DIIPIQRRER FLDKVFSNLI DIRNISTALT
LALRARQSQH PIVSQISDIM ERFTTEFEPF VYYGARQHQA KHVYEHERYN NPKFALFAEQ
TERDAASRKL ELNGYLTKPT TRLGRYTLLL DKIHSRTSPN HPDKENIPFI IDAIKHLLQR
VNNAAGTAKN RFDLEQIHRH LTFKNKKDIM DLHLLDQGRS IIKQGTLRKT ASMDSTEYQV
ILLDHYLVTA KVKVLNAVEH YCVQKRPIPI ELLGVILPPL PDACSLQRKK SSSTLLFSSS
TASSPTSTPN NNRISPSTAH NQILDSGPKQ GSPITFFHQG RNMDSTYTLY APNEHNRKTW
NEVIQKQREI KFKRKPVFDV VDSVKRYEFF AEIRAHHMVI FDQGQSYLLA TDGGLYIGPN
NGTGIPRKIL PLEKVYQVHV LEDYQLLLVL SDHTLWQYPL DITINGRPDG SQSIQHFGRK
IRSNVSFFHV GECLGQTLIC VPNSSSVNGT EIDLYEPSMP KTELKKKSLL GRLSIRATSS
LSLMNTQVTH LKPIYSPCDV WAIDNTRSML LLTTPVGIIA VDMKTKKADG LLDPSDKYLE
FITRHEKIDE QIKMNPAIKR IAVFSVPNGD YLVCYDKFAF YIDKKGRRTQ HKFKIEWEGH
PTAFAFHYPH VIAFEQQFIE IRSVIDGHLQ QVIQEKNVYC LQNGHKSKDA LILGTMLDRS
NPLYQQIFQL QPIS
//
