ID S2XKP2_9BACL Unreviewed; 194 AA.
AC S2XKP2;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Transcription factor FapR {ECO:0000256|HAMAP-Rule:MF_01814};
DE AltName: Full=Fatty acid and phospholipid biosynthesis regulator {ECO:0000256|HAMAP-Rule:MF_01814};
GN Name=fapR {ECO:0000256|HAMAP-Rule:MF_01814};
GN ORFNames=HMPREF1210_01208 {ECO:0000313|EMBL:EPD52828.1};
OS Paenisporosarcina sp. HGH0030.
OC Bacteria; Bacillota; Bacilli; Bacillales; Planococcaceae;
OC Paenisporosarcina.
OX NCBI_TaxID=1078085 {ECO:0000313|EMBL:EPD52828.1, ECO:0000313|Proteomes:UP000014412};
RN [1] {ECO:0000313|EMBL:EPD52828.1, ECO:0000313|Proteomes:UP000014412}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HGH0030 {ECO:0000313|EMBL:EPD52828.1,
RC ECO:0000313|Proteomes:UP000014412};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D., Dover J.,
RA Kim K., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Paenisporosarcina sp. HGH0030.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional factor involved in regulation of membrane
CC lipid biosynthesis by repressing genes involved in fatty acid and
CC phospholipid metabolism. {ECO:0000256|HAMAP-Rule:MF_01814}.
CC -!- SIMILARITY: Belongs to the FapR family. {ECO:0000256|HAMAP-
CC Rule:MF_01814}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPD52828.1}.
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DR EMBL; AGEQ01000006; EPD52828.1; -; Genomic_DNA.
DR RefSeq; WP_016427718.1; NZ_KE150421.1.
DR AlphaFoldDB; S2XKP2; -.
DR STRING; 1078085.HMPREF1210_01208; -.
DR PATRIC; fig|1078085.3.peg.1183; -.
DR eggNOG; COG1349; Bacteria.
DR HOGENOM; CLU_095708_0_0_9; -.
DR Proteomes; UP000014412; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_01814; Transcrip_fact_FapR; 1.
DR InterPro; IPR001034; DeoR_HTH.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR017275; Transcription_factor_FapR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF08220; HTH_DeoR; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR PIRSF; PIRSF037733; Transcription_factor_FapR; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01814};
KW Fatty acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_01814};
KW Fatty acid metabolism {ECO:0000256|HAMAP-Rule:MF_01814};
KW Lipid biosynthesis {ECO:0000256|HAMAP-Rule:MF_01814};
KW Lipid metabolism {ECO:0000256|HAMAP-Rule:MF_01814};
KW Reference proteome {ECO:0000313|Proteomes:UP000014412};
KW Repressor {ECO:0000256|HAMAP-Rule:MF_01814};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_01814};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_01814}.
FT DOMAIN 8..46
FT /note="HTH deoR-type"
FT /evidence="ECO:0000259|Pfam:PF08220"
FT DOMAIN 102..172
FT /note="MaoC-like"
FT /evidence="ECO:0000259|Pfam:PF01575"
SQ SEQUENCE 194 AA; 22111 MW; DCCE6AB013C63148 CRC64;
MKRSKKERQQ LLIDTIKNNP FITDEELAGQ FSVSVQTIRL DRLELSIPEL RERIKHVASK
SFEDEVRSLP LNEVIGEMVD IELDVRAISL FDVKTEHVFK RNRIARGHHL FAQANSLAVA
VINDELALTV KSNLSFVKPV KLGDRVIAKA AVTKKDQDKN RTFVEVTSTV ENEIVFEGHF
EMYRTNEHGK GDVS
//
