ID S2Y3M1_9ACTN Unreviewed; 402 AA.
AC S2Y3M1;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Ketosynthase family 3 (KS3) domain-containing protein {ECO:0000259|PROSITE:PS52004};
GN ORFNames=HMPREF1211_05720 {ECO:0000313|EMBL:EPD58781.1};
OS Streptomyces sp. HGB0020.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1078086 {ECO:0000313|EMBL:EPD58781.1, ECO:0000313|Proteomes:UP000014410};
RN [1] {ECO:0000313|EMBL:EPD58781.1, ECO:0000313|Proteomes:UP000014410}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HGB0020 {ECO:0000313|EMBL:EPD58781.1,
RC ECO:0000313|Proteomes:UP000014410};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D., Dover J.,
RA Kim K., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Streptomyces sp. HGB0020.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPD58781.1}.
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DR EMBL; AGER01000023; EPD58781.1; -; Genomic_DNA.
DR RefSeq; WP_016435622.1; NZ_KE150428.1.
DR AlphaFoldDB; S2Y3M1; -.
DR STRING; 1078086.HMPREF1211_05720; -.
DR PATRIC; fig|1078086.3.peg.5773; -.
DR HOGENOM; CLU_000022_69_0_11; -.
DR OrthoDB; 9808669at2; -.
DR Proteomes; UP000014410; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProt.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000014410};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 1..401
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 402 AA; 41514 MW; 166855D6FD0B8DB5 CRC64;
MTRLAITGMG FTLAGGVRTA GDFWHRVREG ESALTAHTAF NDRGVPTVMA GQLTHDPVVE
GLDPKHASKY SREILAALAS IDEALADAGV GDFDPHRAGV VASSSRGPLQ WWEREFDSAS
GIGRVLGGLP GAPASIAAIR TGVQGYVTTV SSACVGGTHA LRSAAAELRS DEADVMVVVG
HEFPLTANLL QVYTDPKSRV LSLGTTAADS IRPYDADRDG TALGEGAVAL VLEREADALA
RGAHVYAWVL ATGVANEAAH PTTMELSGEK TAALAERVIK KSDLSVGDIG HVCGHGTGTR
SNDVAESRAV RRVFGDDTEV TLTSVKPIFG HLFGASSLVN VAATASMLDA QTIAPTANSV
RADAECGLDS VFGGARRTDV RAALSFAFAL GSQSSVVALQ AA
//
