ID S2ZIF0_9ACTN Unreviewed; 752 AA.
AC S2ZIF0;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN ORFNames=HMPREF1211_02816 {ECO:0000313|EMBL:EPD63689.1};
OS Streptomyces sp. HGB0020.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1078086 {ECO:0000313|EMBL:EPD63689.1, ECO:0000313|Proteomes:UP000014410};
RN [1] {ECO:0000313|EMBL:EPD63689.1, ECO:0000313|Proteomes:UP000014410}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HGB0020 {ECO:0000313|EMBL:EPD63689.1,
RC ECO:0000313|Proteomes:UP000014410};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D., Dover J.,
RA Kim K., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Streptomyces sp. HGB0020.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPD63689.1}.
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DR EMBL; AGER01000012; EPD63689.1; -; Genomic_DNA.
DR RefSeq; WP_016432770.1; NZ_KE150427.1.
DR AlphaFoldDB; S2ZIF0; -.
DR STRING; 1078086.HMPREF1211_02816; -.
DR PATRIC; fig|1078086.3.peg.2853; -.
DR HOGENOM; CLU_005108_1_1_11; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000014410; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000014410};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 645..667
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 679..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 181..328
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 730..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..745
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 752 AA; 78155 MW; B29AB43818348E6A CRC64;
MATFLHRVGR WAFRRRRVVV LAWVVVLAAV FLGASGASEA PDDSSSMPGI ESQQAFDLIN
ERFPGAEADG AQARIVFVAD HGQHITAAAN RAAIGDLVAA VADGPQVADA TSPFGTNAVS
KDKSTAYATV TYKVASDDLT DASKTDLTKA VEQARDAGLT VEVGGSALET DAAEGLGEAL
GVVVAAVVLL ITFGSLAAAG LPLLTAILGV CVSLAGITAV SSAFGFSSTV GELAMMLGLA
VGIDYSLFVV SRYREERSKG HQPQEAAALA AGTAGSAVVF AGLTVVIALL GLSVIGVPML
TKMGIGSAGA VVVAVLIALT AVPALLGFWP DAVLARRDRK GVRPARIKLF RRIGRTRTAG
TSAKEARGVR WARFVVRRPL PVLLLSVIGL GALAVPSLDL RMGMPGDEAK STATTERRAY
DDLAEGFGPG FNGPLAVVVD ARKADDPKAA VWTVSAKLAA TKGVVSLSPA RFNEAKDTAV
ISAVPSTAPT SRETQDLVHT IRGGRSAVES ATGAEFKVTG TTALNIDVGQ KMQDALIPYL
AVVVGLAFVL LMLVFRSILV PLKAALGFLL SVGAALGAIV TVFQQGHGAG FFGVDETGPI
MSTMPIFLVG IVFGLAMDYQ VFLVSRIREA HIHGEGPGQA VVTGFRHSAH VVAAAALIMM
AVFGGFMTGG ESMVKMVGFG LAGAVFFDAF VVRMAFVPAV LALLGKRAWW LPSWLDRLLP
RVDVEGEALT KHAHTPRDSS DNDDRRTPMT VV
//
