ID S2ZR34_9ACTN Unreviewed; 971 AA.
AC S2ZR34;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=beta-galactosidase {ECO:0000256|ARBA:ARBA00012756};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
DE AltName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230};
GN ORFNames=HMPREF1211_01918 {ECO:0000313|EMBL:EPD66394.1};
OS Streptomyces sp. HGB0020.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1078086 {ECO:0000313|EMBL:EPD66394.1, ECO:0000313|Proteomes:UP000014410};
RN [1] {ECO:0000313|EMBL:EPD66394.1, ECO:0000313|Proteomes:UP000014410}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HGB0020 {ECO:0000313|EMBL:EPD66394.1,
RC ECO:0000313|Proteomes:UP000014410};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D., Dover J.,
RA Kim K., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Streptomyces sp. HGB0020.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPD66394.1}.
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DR EMBL; AGER01000005; EPD66394.1; -; Genomic_DNA.
DR RefSeq; WP_016431890.1; NZ_KE150426.1.
DR AlphaFoldDB; S2ZR34; -.
DR STRING; 1078086.HMPREF1211_01918; -.
DR PATRIC; fig|1078086.3.peg.1951; -.
DR HOGENOM; CLU_002346_0_2_11; -.
DR OrthoDB; 9762066at2; -.
DR Proteomes; UP000014410; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR004199; B-gal_small/dom_5.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR023232; Glyco_hydro_2_AS.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR023230; Glyco_hydro_2_CS.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032312; LacZ_4.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF02929; Bgal_small_N; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR Pfam; PF16353; LacZ_4; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SMART; SM01038; Bgal_small_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS00719; GLYCOSYL_HYDROL_F2_1; 1.
DR PROSITE; PS00608; GLYCOSYL_HYDROL_F2_2; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000014410}.
FT DOMAIN 709..968
FT /note="Beta galactosidase small chain/"
FT /evidence="ECO:0000259|SMART:SM01038"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 971 AA; 106651 MW; 152A1FAB5C88DDDF CRC64;
MTTRTPSAVD FAEDVSPGSG ALPPRAWYPS SDAKSLSLNG SWRLRVSPTA DAEDDSFAEP
GFDAGNWAEI TVPGHWVLQG DGAFGLPIYT NHLYPFPVDP PHVPTENPTG DHLRVFDLPH
DWPGDGGAVL RFDGVESCAR VWLNGTDIGG FKGSRLPHEF AVGHLLKPAG NVLAVRVHQW
SAGSYLEDQD QWWLPGIFRD VTLLHRPAGG VRDFFVHASY DHRTGEGTLR VDSDVEGRVS
VPALDVDVAT GEAVTVPVRP WSAEVPTLYD GELVTEGERV PLRIGFRTVE RDDGLIKVNG
RAILFKGVNR HEWHPDSGRA LDAETMLEDV LLMKRHNVNA VRTSHYPPHP AFLDLCDTYG
LWVIDECDLE THGFTEQAWR DNPVDDDRWT PALLDRAARM VERDKNHPSV IVWSLGNEAG
TGRGLTAMAE WIRDRDTSRL VHYEGDIDCR DTDMYARMYA DHAEVERIGK GLDGGTHRRR
QLPFILCEYG HAMGNGPGGL ADYQRLFEAH DRLQGGFVWE WIDHGITHPE LGYAYGGDFG
EELHDGNFVC DGLVFPDRRP SPGLVEFKKV IEPVGIEGEG FYGTGGSGGT VGTVGSAGTV
RITNKRDFAD LSDLVFEWSY QVDGETVEAG TLAVPSLAPG ASAEVKLPEP AGEVQGFESR
WTVRALLAAD TSWGPRGHEV AWGQGPVTAR RLPCVVASDA PVLDERVITL GPASFDARTG
ALKTIGGVEV SGLRLDVWRA PTDNDEGAAW QSDTRWATVW RTHGLHRMRH RIGSVEAGDD
ALTVRTRVAP AAREFGLRTV YRWTSDGSRL KLTVSVAPDG EWTMPLPRLG IRFGLRRADA
VKWFGGGPGE GYPDTDTAAR TGRWESTVDL LQTPYVRPQE NGARPDVRWA EIGGLRMEGD
PEFSFTARRW TTEQLDAATH LTDLTPGDTV WVNLDHALHG IGTGSCGPGV LPQYQLKAEP
AEFSFIFTEL G
//
