ID S3AQ15_9ACTN Unreviewed; 333 AA.
AC S3AQ15;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=D-alanine-D-alanine ligase {ECO:0000313|EMBL:EPD78429.1};
GN ORFNames=HMPREF1527_00751 {ECO:0000313|EMBL:EPD78429.1};
OS Atopobium sp. oral taxon 199 str. F0494.
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales; Atopobiaceae;
OC Atopobium.
OX NCBI_TaxID=1203602 {ECO:0000313|EMBL:EPD78429.1, ECO:0000313|Proteomes:UP000014384};
RN [1] {ECO:0000313|EMBL:EPD78429.1, ECO:0000313|Proteomes:UP000014384}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0494 {ECO:0000313|EMBL:EPD78429.1,
RC ECO:0000313|Proteomes:UP000014384};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Kirega A., Tanner A.C.,
RA Dewhirst F.D., Izard J., Walker B., Young S., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Atopobium sp. oral taxon 199 F0494.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-alanine--D-alanine ligase family.
CC {ECO:0000256|ARBA:ARBA00010871}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPD78429.1}.
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DR EMBL; ATCH01000001; EPD78429.1; -; Genomic_DNA.
DR RefSeq; WP_016477366.1; NZ_KE150486.1.
DR AlphaFoldDB; S3AQ15; -.
DR STRING; 1203602.HMPREF1527_00751; -.
DR PATRIC; fig|1203602.3.peg.747; -.
DR eggNOG; COG1181; Bacteria.
DR HOGENOM; CLU_039268_1_0_11; -.
DR OrthoDB; 9813261at2; -.
DR Proteomes; UP000014384; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008716; F:D-alanine-D-alanine ligase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR000291; D-Ala_lig_Van_CS.
DR InterPro; IPR011095; Dala_Dala_lig_C.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR PANTHER; PTHR23132; D-ALANINE--D-ALANINE LIGASE; 1.
DR PANTHER; PTHR23132:SF23; D-ALANINE--D-ALANINE LIGASE B; 1.
DR Pfam; PF07478; Dala_Dala_lig_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS00843; DALA_DALA_LIGASE_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Cell shape {ECO:0000256|ARBA:ARBA00022960};
KW Cell wall biogenesis/degradation {ECO:0000256|ARBA:ARBA00023316};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:EPD78429.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Peptidoglycan synthesis {ECO:0000256|ARBA:ARBA00022984};
KW Reference proteome {ECO:0000313|Proteomes:UP000014384}.
FT DOMAIN 115..326
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
SQ SEQUENCE 333 AA; 35533 MW; 0E823BD93FE059E5 CRC64;
MAAKVAVIMG GTSFERNFSL LSGRLVSEAL AESGFDVLTL DADANLVQTL RAEKPAVAFI
CMHGAGGEDG AVPALLEFLR IPYVGSRPAS CRAAWNKADM PFLMRRVYDK GESLVVWPPQ
LVLPASAFKD LGAAQALDII PERLGGGTGF PLAVKPVHGG SAMGLSRVDS PDDLGSALMA
AFAYDDSVII QRWIEGVEVS LTVLGTPGAE KVLPPVEIEV LEGIYDTDAR LETSRVNHFC
PARDESLAAL GGNVENARIA LEQAAREVYR AYDCRDFARV DFIWDGHKAM VMGLKTFPGL
TETSLVPMAV EAAGFELREV LADLVNGALA RGN
//
