ID S3DAZ0_GLAL2 Unreviewed; 2129 AA.
AC S3DAZ0;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Thiolase-like protein {ECO:0000313|EMBL:EPE34890.1};
GN ORFNames=GLAREA_10585 {ECO:0000313|EMBL:EPE34890.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE34890.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE34890.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
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DR EMBL; KE145355; EPE34890.1; -; Genomic_DNA.
DR RefSeq; XP_008077877.1; XM_008079686.1.
DR GeneID; 19469631; -.
DR KEGG; glz:GLAREA_10585; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_6_0_1; -.
DR OMA; YCRGDGC; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR030918; PT_fungal_PKS.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR04532; PT_fungal_PKS; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 1.
DR Pfam; PF16073; SAT; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 377..809
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1639..1720
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1765..1842
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1726..1772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2129 AA; 229810 MW; 0E3C406010D03A5D CRC64;
MSGTSNQKVF FLFGDQSLDT YGFLANFLHR SSPSLLSKTF IEQASDALCR EVNALSNLER
NKIPRFSSLE DLNERYHISG IKHSGIESAL LCATQIAHYL DRAEKVPEDS ASPNNTTLVG
LSTGLFAAAA ISCSASLSAL IQVGVQATVL AFRTGSYVAA LADQLGGAND NANPWAYSIS
ADEAQAASKL DEFHAEKAIS HASRAYISAT TPDSVAISGP PSTLEALWAS DAFSVTPTPL
PLYGPYQASH LHPELQIEKV LGLKNSRISD VLESSRPNSR ILSSATGQSF EEQSALQLFS
AVAENVLTKS SHLQNVLDGC KSESTGRTLV IPVGPTSFAT TVVDSLRSAS GSDVVLRRAP
FGNNEPAPFA GSGSSSTGKL AIVGMAGRFP DAASHELLWE LLEKGLAVHR EVPPDRFPVK
THVDPSGKTV NTSHTPFGCW IENPGLFDPR FFNMSPREAF QTDPMQRMAL STAFEALEMS
GYTPNRTPST RLDRVGTFYG QTSDDWREIN AAQEVDTYFI TGGVRAFGPG RINYHFGFSG
PSFNVDTACS SSAAALQLAY TSLCAKDCDT AIVGGLSCMT NSDIFAGLSR GQFLSKTGPC
ATFDNDADGY CRADGVGTII VKRLEDAISD KDNVLAVILG SATNHSADAV SITHPHGGTQ
EILYRSILRK AGVDPLDIDY VEMHGTGTQA GDGTEMKSVT NVFAPADRKR TAEQPLYLGA
VKANVGHGEA ASGITALIKV LMMLQKNAIP PHVGIKNTIN VGFPKDLAER NVNIAFHKTP
LRARAGMPRR VFLNNFSAAG GNTGILLEDG PTYKNATVDP RSMHVVSVTA KSKSAMFRNA
SRLVDYLEAN PKTTISDLAY TTTARRIQHN WRMTFSASDI QQAKSIIKSK MNDTFVPVHS
VPPKVAYTFT GQGSHYAGLG KDLYNNSSVF RENILEFDRI ARIQGFPSFL PLIDGSVTDV
STLSPVVVQI GMVCFEVAMA RLWASWGVNP SVLVGHSLGE YSALCVSGVL SASDTIYLVG
ARAQLLVEKC TANTHAMLAV QGSVDALNEA LPEMAGSLSV ACINGPRETV LGGEAGAMAD
LAEKLTQSGF KCTKLQVPFA FHTAQVDAIL DDFEKLAASV RFGSANIPLI SPLLGRPLSE
GESIDPTYLR NHAREAVNFL AGLTSSQELG IIDEKTVWIE VGPHSVCSGM VKSTFGATTI
TAPSLRRNEE AYKTISASLC ALQNAGMNID WNEYHRDFSD SVRLLSLPTY SYDDKNYWIQ
YEGDWSLNKG RKAAGALPAP EIVKSSLSTT SVHEVVKETI SDHVATVVTE TDIARPDLRP
LVTGHVVNGS YLCPSSLYGD MAMTVCEYGY KLIDPDVKDL VMDITHMEVP KSLIADPAGK
SQILTLTATI DINRRSASLV FSSGSDKSKV EHAHCRVLFG TREAYLSEFQ RQSYLIQSRV
DWLKKAESEG EAHKIGRGLA YKLFAALVDY DKRYRGMEEV ILHSENMEAT SRVVFQTTPE
DGTFNCSPYW IDSVAHISGF IVNGSDAIDS KENVYISHGW ESFRIAEPLS ATKTYRSYVR
MQPVEKKVLQ GDVYIFDGDR IIGMVGGLKF QCIQRRVLNM LMPPVGAAAA SKPAARAAPP
QVTTKKPVKT AQVTKDSISK VNQRLTSVTS AVMNILATEI GVGLDELVDN LAWNDLGCDS
LMSLTVSGKL REDLEIDVPS SAFTDNATIG EFKAFLSKYE RKESVVTTTS DSSSSHDTAT
PELEDSEDTE VTTPSDTSEE EKEPSNDSEL GNIIRTTIAG EMGVDIDEII DLSDLTEIGM
DSLMSLSILG ILRERTGMNL PADLLANNPS IKAIEKSLNI GGTKAAKPAK APAKKPSAPA
KSISATTERL ATSVLLQGNS KKATKHLWMV PDGSGSATSY TEISEIGPNV AVWGLNSPYM
KVPEEYKCGV IGMASSFISE IKRRQPVGPY LLAGWSAGGV IAFEAVNQLI KNGDEVEQLI
IIDAPCPDII EPLPASLHRW FGEIGLLGDG DLSKLPKWLL PHFAASVTAL SNYSAELIDP
KKSPFVTAIW CEDGVCHLPT DPRPDPFPYG HAQFLLDNRT DFGPNLWDKY LNGERFVTKH
MPGNHFSMMK GDLAKQLGNI IRGAVAQTA
//