ID S3DIE6_GLAL2 Unreviewed; 1025 AA.
AC S3DIE6;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=GLAREA_02235 {ECO:0000313|EMBL:EPE26323.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE26323.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE26323.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010,
CC ECO:0000256|RuleBase:RU004070}.
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DR EMBL; KE145371; EPE26323.1; -; Genomic_DNA.
DR RefSeq; XP_008087642.1; XM_008089451.1.
DR AlphaFoldDB; S3DIE6; -.
DR STRING; 1116229.S3DIE6; -.
DR GeneID; 19461293; -.
DR KEGG; glz:GLAREA_02235; -.
DR eggNOG; KOG0478; Eukaryota.
DR HOGENOM; CLU_000995_7_0_1; -.
DR OMA; NRCSFAD; -.
DR OrthoDB; 5476523at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0031261; C:DNA replication preinitiation complex; IEA:UniProt.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0005656; C:nuclear pre-replicative complex; IEA:UniProt.
DR GO; GO:0043596; C:nuclear replication fork; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR GO; GO:0006279; P:premeiotic DNA replication; IEA:UniProt.
DR CDD; cd17755; MCM4; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008047; MCM_4.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF66; DNA REPLICATION LICENSING FACTOR MCM4; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF21128; MCM4_WHD; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01660; MCMPROTEIN4.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922}.
FT DOMAIN 605..813
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 1..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 575..602
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1025 AA; 113851 MW; ED67AE8B697510E0 CRC64;
MSSPSHRRQR SSQSGTPRRA SQRNAMPSSP PDPAAAQLQS EAASSQNPRS TPRRAPQSSS
PMNYRSSPAE IARMNRERDV SSPLRQMSNT QTTQEDGDRT PRASGLNRES SPIRYEASSS
PGGFGSRQAS MQPDLRSESS ALFVRSSRTP APGSSVNNTR RGDINSENIN TPRTRRRIFM
DENGRLIRDV QEENSEAPTF SNLDPTTSDA QAMGGNSTLC IWGTNISVND TISNFKMFLK
EFSKKYRMWA DGMTQEETQA EEDAETKEYV EMMQQMLTLG VTCLNLDFRN LKAYPPTKKL
WQQAQDYPQD IVTLMDQAIK DVMYSLAEDM MTRERRSQSS TAGPNSQNTA VPSSDPPVPS
SDRMGSEAAT PRADDSAEID WCQEVQKRQY RVRLFGLDST VNMRELNPSD VDKIVAIKGL
VIRTTPILPD MKDAFFKCQV CNHTVKVDID RGRIAEPTEC PRPICKSQNS MQIVHNRSGF
ADKQVIKLQE TPDSVPAGQT PHSVSMCAYD DLVDMCKAGD RVEVTGIFRA SPVRVNPRQR
TVKSVYKTYI DIIHIQKVDK KRMGIDVSTV EQELSEEMTN TIEQTRKVSE EEEEKIKATA
ARPDIYELLS RSLAPSIFEM DDVKKGILLQ LFGGTNKSFE KGGSPKYRGD INILLCGDPS
TSKSQILQYV HKIAPRGVYT SGKGSSAVGL TAYVTRDPET RQLVLESGAL VLSDGGVCCI
DEFDKMSDAT RSVLHEVMEQ QTVSIAKAGI ITTLNARTSI LASANPIGSK YNPNLPVPQN
IDLPPTLLSR FDLVYLILDR IDETNDRRLA RHLLSMYLDD KPQSAAQGEE ILPIEFLTSY
ISYARTNCQP RISAEASSEL VSAYVEMRKL GEDVRAAERR ITATTRQLES MIRLAEAHAK
MRLSDTVTRS DVQEAVRLIK SALKQAATDA RTGLIDMSLL TEGTSSSERR RKADLKNAVL
SLLDDMTRQG QAARYSEVVR RMGEQSSISV EANEFAEAIR GLEQEGSVMV VGEGARRSIR
RVTGV
//
