ID S4AU97_9ACTN Unreviewed; 974 AA.
AC S4AU97;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=FAD-binding PCMH-type domain-containing protein {ECO:0000259|PROSITE:PS51387};
GN ORFNames=STRAU_1898 {ECO:0000313|EMBL:EPH44997.1};
OS Streptomyces aurantiacus JA 4570.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
OX NCBI_TaxID=1286094 {ECO:0000313|EMBL:EPH44997.1, ECO:0000313|Proteomes:UP000014629};
RN [1] {ECO:0000313|EMBL:EPH44997.1, ECO:0000313|Proteomes:UP000014629}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JA 4570 {ECO:0000313|EMBL:EPH44997.1,
RC ECO:0000313|Proteomes:UP000014629};
RA Gruening B.A., Praeg A., Erxleben A., Guenther S., Mueller M.;
RT "Draft Genome Sequence of Streptomyces aurantiacus, Which Produces
RT Setomimycin.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPH44997.1}.
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DR EMBL; AOPZ01000069; EPH44997.1; -; Genomic_DNA.
DR RefSeq; WP_016640028.1; NZ_AOPZ01000069.1.
DR AlphaFoldDB; S4AU97; -.
DR PATRIC; fig|1286094.4.peg.1876; -.
DR OrthoDB; 9770306at2; -.
DR Proteomes; UP000014629; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.30.70.2740; -; 1.
DR Gene3D; 3.30.43.10; Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR004017; Cys_rich_dom.
DR InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016167; FAD-bd_PCMH_sub1.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR InterPro; IPR016171; Vanillyl_alc_oxidase_C-sub2.
DR PANTHER; PTHR11748:SF119; D-2-HYDROXYGLUTARATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11748; D-LACTATE DEHYDROGENASE; 1.
DR Pfam; PF02754; CCG; 2.
DR Pfam; PF02913; FAD-oxidase_C; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR Pfam; PF13183; Fer4_8; 1.
DR SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000014629}.
FT DOMAIN 48..277
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
SQ SEQUENCE 974 AA; 105236 MW; 2CEED2E48BBE2685 CRC64;
MTISTESTEV EHGEVGGDLA RRLRADLDGE VAFDDYSRHL FARDASMYAI TPLGVVFPRH
AEDVRAAVAA AAEHGVSVVP RGAGTSLAGQ TTGPGIVLDL SRHMRRIVAL EPDGRTALVE
PGVVQDQLNR AAAPHGLMFG PDTSTSNRAT IGGMVGNNSA GSGSLRYGMT IDHVRALDVV
LADASTAHLA PLTAREHADR ARGTGLDGRI HRELPALVAA HADAIAAGYP GHWRRAGGYR
LDRLAREDTP FDLAKFLVGS EGTLAITTRA LVDLVPKPAH TVFAVGHFTS VAGAIEATQD
ALACDPAAVE LMDRTILDLS RQKIEYASLG TVLEGDPDAL LFVSFTGDDE RELIGSVERL
KKLWQRHGHG YHTLAAITQA DQTALMKVRK SSLGLLMAAS EGTRRPLAFI EDTAVDPVHL
PAYTNRLKKV LDRHGLTAGF YGHCSVGCLH IRPFLDVTDP AQRQTMREVA EEIKDLVTEY
GGVNSSEHGD GLARSEFNRE LFGDELYEAM RRVKGLFDPD NRLNPGKIVD APAMTEHLRD
PALPPAPGLR TRLDFEVSGG MRAAADRCMN IGLCRKSETG VMCPSYMATR NEEDSTRGRA
GALVKALSEP DPHQALGDER LHEVLDLCLM CKACKSECPL GVDMASLKAE ALAHHHDEHG
IPLRSRIFGA IRGLNRLGSA TAPLSNLPGR IPLLRRLLHR TVGITPHRPL PRYVRRNLVR
WFNRRPAAVV AAPRGTVVML ADSFTTYTEP EIGRAAVELL ERAGWAVQLE SGGCCGRAAL
SKGLLDEASD KAFQLVHRIT ETTPPDAPVT GCEPSCLMTL RDEHKALLPL DSAREAVTGR
VRQLEELLTE AIDDGGLTLR EDSWLSGRTL LFHGHCHQKA EVGTAATVAL LRRIPGVEVK
ELDAGCCGMA GSFGFESEHY DVSMTVGEDR LFPAVRAASE GTVVVATGAS CRQQIFHGTE
RNAWHPVQLV REAL
//
