ID S4IEM7_GARVA Unreviewed; 156 AA.
AC S4IEM7;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=dTMP kinase {ECO:0000256|ARBA:ARBA00012980};
DE EC=2.7.4.9 {ECO:0000256|ARBA:ARBA00012980};
DE Flags: Fragment;
GN ORFNames=HMPREF1572_01346 {ECO:0000313|EMBL:EPI54082.1};
OS Gardnerella vaginalis JCP7275.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Gardnerella.
OX NCBI_TaxID=1261057 {ECO:0000313|EMBL:EPI54082.1, ECO:0000313|Proteomes:UP000014557};
RN [1] {ECO:0000313|EMBL:EPI54082.1, ECO:0000313|Proteomes:UP000014557}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCP7275 {ECO:0000313|EMBL:EPI54082.1,
RC ECO:0000313|Proteomes:UP000014557};
RA Weinstock G., Sodergren E., Lobos E.A., Fulton L., Fulton R., Courtney L.,
RA Fronick C., O'Laughlin M., Godfrey J., Wilson R.M., Miner T., Farmer C.,
RA Delehaunty K., Cordes M., Minx P., Tomlinson C., Chen J., Wollam A.,
RA Pepin K.H., Bhonagiri V., Zhang X., Warren W., Mitreva M., Mardis E.R.,
RA Wilson R.K.;
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC ChEBI:CHEBI:456216; EC=2.7.4.9;
CC Evidence={ECO:0000256|ARBA:ARBA00001008};
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC {ECO:0000256|ARBA:ARBA00009776}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPI54082.1}.
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DR EMBL; ATJS01000158; EPI54082.1; -; Genomic_DNA.
DR RefSeq; WP_020761416.1; NZ_KE348639.1.
DR AlphaFoldDB; S4IEM7; -.
DR PATRIC; fig|1261057.4.peg.1140; -.
DR HOGENOM; CLU_049131_2_0_11; -.
DR Proteomes; UP000014557; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01672; TMPK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039430; Thymidylate_kin-like_dom.
DR InterPro; IPR018095; Thymidylate_kin_CS.
DR InterPro; IPR018094; Thymidylate_kinase.
DR NCBIfam; TIGR00041; DTMP_kinase; 1.
DR PANTHER; PTHR10344; THYMIDYLATE KINASE; 1.
DR PANTHER; PTHR10344:SF4; THYMIDYLATE KINASE; 1.
DR Pfam; PF02223; Thymidylate_kin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000313|EMBL:EPI54082.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000313|EMBL:EPI54082.1}.
FT DOMAIN 1..127
FT /note="Thymidylate kinase-like"
FT /evidence="ECO:0000259|Pfam:PF02223"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EPI54082.1"
SQ SEQUENCE 156 AA; 17332 MW; EB18A85CABE1449C CRC64;
ALLFAADRAQ HAAQIIIPAL RRGAVVITDR YIDSSLAYQS GGRELTMQDV RDLSEWASNC
LWPNRTYLLD MSEKDAAVRL HGQADRMESA GLDFARRTRE AFLDLAKQNA QRFCVLDATL
PACDLSKLIA KDMCELLDNA GICDKKSPEA PENQGF
//
