ID S4R1F1_MOUSE Unreviewed; 796 AA.
AC S4R1F1;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Rho guanine nucleotide exchange factor (GEF) 5 {ECO:0000313|Ensembl:ENSMUSP00000138192.2};
DE Flags: Fragment;
GN Name=Arhgef5 {ECO:0000313|Ensembl:ENSMUSP00000138192.2,
GN ECO:0000313|MGI:MGI:1858952};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000138192.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000138192.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000138192.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000138192.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000138192.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR MaxQB; S4R1F1; -.
DR PeptideAtlas; S4R1F1; -.
DR ProteomicsDB; 345162; -.
DR Antibodypedia; 18513; 374 antibodies from 36 providers.
DR Ensembl; ENSMUST00000182924.2; ENSMUSP00000138192.2; ENSMUSG00000033542.14.
DR AGR; MGI:1858952; -.
DR MGI; MGI:1858952; Arhgef5.
DR VEuPathDB; HostDB:ENSMUSG00000033542; -.
DR GeneTree; ENSGT01030000234571; -.
DR HOGENOM; CLU_353236_0_0_1; -.
DR ChiTaRS; Arhgef5; mouse.
DR Proteomes; UP000000589; Chromosome 6.
DR Bgee; ENSMUSG00000033542; Expressed in placenta labyrinth and 194 other cell types or tissues.
DR ExpressionAtlas; S4R1F1; baseline and differential.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11940; SH3_ARHGEF5_19; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845:SF2; DH DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:S4R1F1,
KW ECO:0007829|PeptideAtlas:S4R1F1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 427..611
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 709..770
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..114
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..270
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000138192.2"
SQ SEQUENCE 796 AA; 90161 MW; 95542C19C811E6DB CRC64;
XEVASTLKRH SHPPPLTLSS GLHRSSKGSF SLVPDSTVAR QHRPLPSTPE SPNHTQTSIP
SRLRYNKPLP PTPDMPEFYH PSISSSYISR MYRPLPPVPI IDPSSEPPPL PPKSRGRSKS
IQGGVIHSGG QAKPRPNNQD WTASTLSVGR TSWPPATGRS TESLPLTSRC NNEVSPGLAF
SNMTNLLSPS SPTTPWIPDL QRPTTKDESG LTEESEPPVR GSFRRSAPQE EFNNTRRSAL
GSRKNSEKPL HHQLEKASSW PHRRDPARTS ESSSEQVVLG QVPNKQKGWN RQGLRRPSIL
PESSSDLRNP AAGRLPGSSD SVVFREKKPK EGMGGFSRRC SKLISSQLLY QEYSDVVLNK
EIQSQQRLDS LAEPHGLSSP RHRRKALVSS DSYLQRLSMA SSGSLWQEIP VVRNSTVLLS
MTHEDQKLQE AKFELIVSEA SYLRSLNIAV DHFQHSAQLR GTLSNQDHQW LFSRLQDVRD
VSTTFLSDLE ENFENNIFSF QVCDVVLNHA ADFHRVYLPY VTNQTYQERT FQSLMNSNSS
FREVLEKLES DPICQRLSLK SFLILPFQRI TRLKLLLQNI LKRTQPGSSE EAEATKAHHA
LEKLIRDCNS NVQRMRRTEE LIYLSQKIEF ECKIFPLISQ SRWLVKSGEL TALEFSVSPG
LRRKLTTRPV HLHLFNDCLL LSRPRESEKL RWISALAMPR EELDLLECYD SPQVQCLRAY
KPRENDELAL EKADVVMVTQ QSSDGWLEGV RLSDGEQGWF PVQQVEFISN PEVRAQNLKE
AHRVKTAKLQ LVEQQV
//
