ID S4R4J6_PETMA Unreviewed; 1192 AA.
AC S4R4J6;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Diaphanous related formin 1 {ECO:0008006|Google:ProtNLM};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000000125.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000000125.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC subfamily. {ECO:0000256|ARBA:ARBA00008214}.
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DR AlphaFoldDB; S4R4J6; -.
DR STRING; 7757.ENSPMAP00000000125; -.
DR Ensembl; ENSPMAT00000000125.1; ENSPMAP00000000125.1; ENSPMAG00000000108.1.
DR GeneTree; ENSGT00940000157822; -.
DR HOGENOM; CLU_002356_0_0_1; -.
DR OMA; VTKMSIF; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.58.630; -; 1.
DR Gene3D; 6.10.30.30; -; 1.
DR Gene3D; 1.10.20.40; Formin, diaphanous GTPase-binding domain; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR044933; DIA_GBD_sf.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF6; PROTEIN DIAPHANOUS; 1.
DR Pfam; PF06346; Drf_FH1; 2.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300}.
FT DOMAIN 41..417
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 739..1142
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 1166..1192
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 19..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 436..523
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1015..1049
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1121..1160
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 608..725
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1192 AA; 132656 MW; A3AAB94ADDDBD05E CRC64;
VIMQLDRFAS IRVAAKKDKE KGDRPVVVQR GGGPSSLPFG GDDLTEDQIH TFFEKMLEDM
NLSEAHKAPL RHKDEKTKRD MVLQYMASSS KTGGTHKRDT ALSGKDYITE LTGLRKMEHD
SDQERLLSCL ESLRVSLTSN PVSWVELFGD EGLKILLDIL QDLQEKQSPN HFDWKIQLEI
VRCLRAFMNN KVGLRAMLAT HNGVLLLARA VEPRHPSMMV EAVRLLSALS ILDEDHFDGA
KPSSRVLDAL AECAEICEQE RFQPIVEGLD VKQSLSLKIA CFILINALVE TPEDLEFRIH
LRNEFMRNGL GKALTHLREI QNEQLEVQLR VFDEGREGDF QDFSQRLQDI RAFVCTDIND
VYAFLSNTVK DTQAEQPFLS IMQHLLLIRN DFLVRPQYFR LIEECVSQVV LHRGGVDPDF
RSTSRFHVDV DNLIENMVNQ QKVEQYELRA SELEKKLEAE MTVRQEAMAE LKRREGEAET
RRYEAEARAT QLEEEKTRIA QELQLQVQEK LRLQEEFARA REEIKPAAPD STGGAPAPPP
APPLPGMIVI PPPPPLPGTV GIPPAPPLPG MGGIPPAPPL PGMGGIPPAP PLPGMGGIPP
PPPLPGMGGI PPAPPLPGMG GIPPPPPLPG MGGIPPPPPL PGMGGIPPPP PLPGMGGIPP
PPPLPGMGGI PPPPPLPGMG GIPPPPPLPG MGGPPPPPPL PGMGPPPPPP APGMGGPPPP
PGLFTFAAQR PGLPFGLQPK KEYKPEISTK RANWAKIRPE EFKENSFWTK AKEERFENPD
VLSKLAQTFA AQAAKVRAQK EQEGVEKDKP PSKKKIKELK VLDQKSGQNL SIFLGTLKMP
YTEIKKIILE VNEEKITESM IQNLIKQLPE ADQLEALAGF KDEYDDLAEA EQFSVVIGSV
TRLRSRLTAI QFMLQFEEQV SSVKPDVVAV TAACEEVQQS DAFSRLLEIV LLFGNYMNAG
SRNAQTFGFN ISYLCKLRDT KSADQKQTLL HFLAEVCEAE YPEVLKFTED LSHVEKASRV
SAENLQKNLK QMENQIEQLE KDIQSFPSTE DKNDKFVEKM TISFMRKARE QYGRLALMFD
NMQTLFDGLG EYFVFNTKKV SVEEFFGDLT NFRSMFMQAV KDNVRRREAE EKIQKAQLAK
ERAEKERLEK QNKKRLLLLK MHTDGDETGV MDSLMEALQS GAAFKRKRAP RQ
//
