ID   S4R6G9_PETMA            Unreviewed;       667 AA.
AC   S4R6G9;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=FAST kinase domain-containing protein 4 {ECO:0000256|ARBA:ARBA00040471};
DE   AltName: Full=Protein TBRG4 {ECO:0000256|ARBA:ARBA00043220};
DE   AltName: Full=Transforming growth factor beta regulator 4 {ECO:0000256|ARBA:ARBA00042265};
OS   Petromyzon marinus (Sea lamprey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX   NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000000799.1, ECO:0000313|Proteomes:UP000245300};
RN   [1] {ECO:0000313|Ensembl:ENSPMAP00000000799.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000256|ARBA:ARBA00004305}.
CC   -!- SIMILARITY: Belongs to the FAST kinase family.
CC       {ECO:0000256|ARBA:ARBA00038281}.
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DR   AlphaFoldDB; S4R6G9; -.
DR   STRING; 7757.ENSPMAP00000000799; -.
DR   Ensembl; ENSPMAT00000000801.1; ENSPMAP00000000799.1; ENSPMAG00000000723.1.
DR   GeneTree; ENSGT01030000234607; -.
DR   HOGENOM; CLU_029448_0_0_1; -.
DR   OMA; NFNHSQV; -.
DR   Proteomes; UP000245300; Unplaced.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0044528; P:regulation of mitochondrial mRNA stability; IEA:InterPro.
DR   InterPro; IPR013579; FAST_2.
DR   InterPro; IPR010622; FAST_Leu-rich.
DR   InterPro; IPR013584; RAP.
DR   PANTHER; PTHR21228:SF59; FAST KINASE DOMAIN-CONTAINING PROTEIN 4; 1.
DR   PANTHER; PTHR21228; FAST LEU-RICH DOMAIN-CONTAINING; 1.
DR   Pfam; PF06743; FAST_1; 1.
DR   Pfam; PF08368; FAST_2; 1.
DR   Pfam; PF08373; RAP; 1.
DR   SMART; SM00952; RAP; 1.
DR   PROSITE; PS51286; RAP; 1.
PE   3: Inferred from homology;
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT   DOMAIN          597..655
FT                   /note="RAP"
FT                   /evidence="ECO:0000259|PROSITE:PS51286"
FT   REGION          65..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..101
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   667 AA;  74371 MW;  E83ABF4B39C67CF5 CRC64;
     MNQAARISVH GLNPIRASLA LLRVQRHHSL VLRNLKRIEA VGQSNTSCGN IRAYKWAHTT
     VAIGEPQNED SLGKKEAAQD DVGEQLEEED SSKRQESKRQ APRTVEQLLA LANTKDLIPW
     RAAEAVSQLG LAVGRDRVQK EQVISDPRLQ YILKAAESQI SSVGNSLLLG MLRSLQLLLN
     SEKKIIRSLE TELHFRLRRL NFKQLCTAAV IYSRSADSDG RKALWADLVK HIELRWTEIP
     DARTVTLLVT RIGSVSPGFM EKLEEKALEF AEKMTPSEGS KVALAFASRS RRSVPLFRAL
     SYHFTRRRVA HECSVILDVI HAFAKVNFVQ TQVLQRLSGD LLPHVPKLSS PDIARLVKSL
     SYLKWLHIPL FEALAQNIKT NCGSFSSAQL FSIVQSFARL NYTAPEAEPF FVQVHSSLAE
     TAEDLDTYAL IDMVWSLCIL GQATPVLLSR VLQQDFYTKV TEQPSVYSQS YIQKLLHINS
     TANLEIPDYP GPFLPSNELL HKLTVPPVSS TSVSHPAKSK QESTMQSDIA QSLATHVGAD
     TSPGHMRVGV ETIYGWTLDA ETLIDKDCKS LPVIEYEAPH LPASSGTKPL PAGARRLAFL
     ALEYPSFLLS SKNVLGKFQM ARRHISSAGF LLVEIPYFEW LELNSDRVKV SYLKDKISKA
     IAEDMAK
//