ID   S4R8R6_PETMA            Unreviewed;       662 AA.
AC   S4R8R6;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=Peroxidasin {ECO:0000313|Ensembl:ENSPMAP00000001597.1};
OS   Petromyzon marinus (Sea lamprey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX   NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000001597.1, ECO:0000313|Proteomes:UP000245300};
RN   [1] {ECO:0000313|Ensembl:ENSPMAP00000001597.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   STRING; 7757.ENSPMAP00000001597; -.
DR   Ensembl; ENSPMAT00000001604.1; ENSPMAP00000001597.1; ENSPMAG00000001446.1.
DR   GeneTree; ENSGT00940000157666; -.
DR   HOGENOM; CLU_006087_2_2_1; -.
DR   OMA; HTGFRRV; -.
DR   Proteomes; UP000245300; Unplaced.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR   InterPro; IPR019791; Haem_peroxidase_animal.
DR   InterPro; IPR010255; Haem_peroxidase_sf.
DR   InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR   PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR   PANTHER; PTHR11475:SF58; PEROXIDASIN; 1.
DR   Pfam; PF03098; An_peroxidase; 1.
DR   PRINTS; PR00457; ANPEROXIDASE.
DR   SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR   PROSITE; PS50292; PEROXIDASE_3; 1.
PE   4: Predicted;
KW   Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245300}.
FT   REGION          72..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          264..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        273..287
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         405
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ   SEQUENCE   662 AA;  73161 MW;  82A89FAB4B4AC25A CRC64;
     FRYNDLVSPR YLELIANLSG CTAHRRAPSC SDACFHQRYR TVDGSCNNLQ HPMWGASLTA
     FARLVEPAYE NGFNEPRGGG ASGRGRPRRG FPLPTPRRVS AELVGTEKIT PDERHTHMLM
     QWGQFLDHDM DLTVVSPSQA RFSDGEPCAR ACTDDPPCFP IELLPDDPRG GRRGGGGGGA
     AAAAAAAGRC MFFVRSSPVC GSGATSLLMS SVLPREQINQ LTSYIDGSNV YGSSEREAAD
     VRDRSSRRGL LRRGIAVGAA GKHLLPFATG PPTEHMRDER ESPIPCFKKG DQRSNEQLGL
     TSPRVSSHPL VRRDHALVSS PPPPPASTLV RLRQLNPHWD SDTIYHESRK IVGAQMQHIT
     YAHWLPKVLG ADAMRSELRP YAGYDPSVNS AIFNSFATAA FRFGHTLINP VLLRLNESFQ
     PIPEGHLPLH RAFFSPFRLV NEGGIDPLLR GLFATPAKKR VPSELLNLEL TEKLFHMAHS
     VALDLASMNV QRGREHGLPS YAAYREFCNL TAAGDFEGLS GEIRDPVVRE KLRKCTHGLF
     FLPENEKCAG GAIARWPIGS TSWGAGRQXL FTEQFRRLRD GDRLFWYENP GVFSPAQLTQ
     IHQSSLSRVL CDNGDAITLV PPDAFAVSTY PQGYVACGTL PHVDLRMWQD CCQEREREDC
     PH
//