ID S4RAD7_PETMA Unreviewed; 1133 AA.
AC S4RAD7;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=ATP-dependent RNA helicase DHX30 {ECO:0000256|ARBA:ARBA00039388};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE AltName: Full=DEAH box protein 30 {ECO:0000256|ARBA:ARBA00042917};
GN Name=DHX30 {ECO:0000313|Ensembl:ENSPMAP00000002168.1};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000002168.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000002168.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid
CC {ECO:0000256|ARBA:ARBA00004436}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; S4RAD7; -.
DR STRING; 7757.ENSPMAP00000002168; -.
DR Ensembl; ENSPMAT00000002179.1; ENSPMAP00000002168.1; ENSPMAG00000001958.1.
DR GeneTree; ENSGT00940000158279; -.
DR HOGENOM; CLU_001832_1_2_1; -.
DR OMA; QYSCTEH; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0042645; C:mitochondrial nucleoid; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF229; ATP-DEPENDENT RNA HELICASE DHX30; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion nucleoid {ECO:0000256|ARBA:ARBA00023271};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300}.
FT DOMAIN 394..563
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 599..772
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 119..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1133 AA; 126914 MW; 8F0210EA26B097C4 CRC64;
LLQEFPLPKD LLRTVLEHVA SGTTCPTKLS YTNYDGRLKR SVLSVLWPVN LRTEGFGWRK
LQAERHAAAL ACARLKEQGW ISANNKPLSC NEYQAIASQL GVPEDQANSL ALIPQAGDNA
DMGRYQRNNP SGRGHRGAQF QSSLKRDKRY NNIYNLRNLA RLELTTLVPR RTREQVSHAS
EMAELMQKFP NSKTLLLSVV QIATASPSAE KHVRFTVTEQ RPFECHLRLS WPQDMVFVAH
APKKNEAIKR ACAMACAAFK EMGLLDSGNR PLRNVDYNKT ALQDMHAQHR RPTPISLLPA
LATRLHDFLL QVPQRKNYTQ SSEAAQVLGP AEEGEEEACV RCVFTGRPYK PFTPEQAQEL
SEELLSRWRA ANPPVTPGED PLPILDYRDE ILAALEAEDR RVLIVAGETG CGKTTKIPQL
ILESMVSRAG NGAHCNVVVT QPRRISAVSV CQRVRQELGP HLRRNIGYQV RMESSPPTPG
GAVLFCTVGI LLRKLQSNPD LLGVSHVLLD EVHERDVGTD FLLVLLRDVL RRNPRLRLLL
ASATPDTQRL AQYFGGATVL RVPGKLYPVT PYHLRNVCQL MQRHPPSKDS DDPSPDLDFV
TEVVEFICSR GTPGGVLCFL PGWQEIRGVM DRLSQRLNNR LDKHLILPVH SSLSVVDQQA
IFQRPPEGVR KVVLATNIAE TAITIDDIVH VVDTGCHKLQ QYDMRTQVSC LDTVWVSKTN
VVQRRGRAGR CQPGFSYHLF SEEQFAAMPE FETPEILRTP LESLVLQVKL HTPHIPAAQF
LDQALDRPNK YAVEEAVSIL QEIGVLMMDE SLTPLGARLA HMAVEPRLAK ALVLATLFRC
LYPVLVIISS LSRDPFQSGL QQRAAVNKAR RLLAGETRSD HLAFVNALEE WRHAYGDRAD
EQHCASENML HPPAVRYVQG LMRQFSQGIH DANLVENTTE CLHDEALCNE YCRQAELVLG
VLAAALYPNI IQLRLGEVTR EGKLRTDSLV CRTRTGRVLL HSSTLNKTEE EFRSRYLVYY
SAMKSNGRVF VRDSSMVHPL ALLLMTDAPI HCKEGDGEVL LTVGDGDLVR MACRHEDARL
LLGLREAVRS MECELLASSE PGAFPADAQE RHRQLLDILV ETLNAPQEPF TVR
//
