ID S4RD40_PETMA Unreviewed; 1236 AA.
AC S4RD40;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000003122.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000003122.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(out) + hydrogencarbonate(in) = chloride(in) +
CC hydrogencarbonate(out); Xref=Rhea:RHEA:72363, ChEBI:CHEBI:17544,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00034408};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR AlphaFoldDB; S4RD40; -.
DR STRING; 7757.ENSPMAP00000003122; -.
DR Ensembl; ENSPMAT00000003137.1; ENSPMAP00000003122.1; ENSPMAG00000002796.1.
DR GeneTree; ENSGT00940000158259; -.
DR HOGENOM; CLU_002289_1_0_1; -.
DR OMA; NANSMEY; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR001717; Anion_exchange.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR InterPro; IPR002178; PTS_EIIA_type-2_dom.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF47; ANION EXCHANGE PROTEIN; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR00165; ANIONEXCHNGR.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
DR PROSITE; PS51094; PTS_EIIA_TYPE_2; 1.
PE 3: Inferred from homology;
KW Anion exchange {ECO:0000256|ARBA:ARBA00022681};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 705..727
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 748..770
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 790..815
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 822..840
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 896..914
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 926..945
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 984..1005
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1026..1049
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1086..1105
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1112..1131
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1163..1192
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 433..603
FT /note="PTS EIIA type-2"
FT /evidence="ECO:0000259|PROSITE:PS51094"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1236 AA; 136113 MW; 7CFA1DA7C07EEEA8 CRC64;
SSKTTRRPAS PFTNLHELQS ERCAGASAPL ARGEEEDLGR ALSRDRSFDS IISDAHATLP
GDVRRNFNED DYQYHRHSSH NIHKAFSSHL PALSSHRRKG HGAPQGAAAA GKAAQRRGKA
RPPDTPTIAE GQEADATSPV GATLGDDEEE GIGAACGDAR KEESPEDDGE KRRRASPQRA
NEEHEGCKPC YYCGLKSKRL RRRCSERARV AHGACRAAVP PPPPPSSGAA AHGYSLSSRR
RIGSMTDTGS TLYARVPTDE TEASTLGNAQ SDLLRPSAER PGTRVHCVRW KCNGTFQSVR
RCQKFGPHDE NPACTKGFHS VFVELNELVM DPARQELQWK ETARWIKFEE DVEAETDRWG
KPHVASLTFR SLLELRKAIA HGTVLLDLEQ KSLAGITHQV VEQMIISDQI TEQERASVLR
ALLLRHRHPN DAKETTSSFL HRNVSAASLS SLLSGNHAGG EPSVTQPLVG DGAIEMSDLQ
EQKDSVSTGS DPLSRNKSRP DLKLLEKIPH GAEATIVLVG CVDFLQQPAM AFVRLSEGVV
LESVLEVPVP VRFLFVLLGP QQASVDYHEI GRSISTLMSD KDFHEAAYLA DERQDLLTAI
TEFLDCSIVL PPSELTDEGL LRSVAAFQRD MLQKRREEDG RRHPREEPPV QSTRGALVGG
GVRLYDVEDP LQRTGRPFGG VVRDARRRYP FYPSDIKDAV DPQCLAAVIF IYFAALSPAI
TFGGLLGEKT QGLIGVSELI ISTSIQSIFF ALLSAQPLLI VGFSGPLLVF EEAFFSFCWS
QDVEYLTGRL WIGFWLILIV LLTVAFEGSF LVRYISRFTQ EIFSILISII FIYETFYKLF
KVFKEHPLLK TYTIGGTDLA GSGVWGNASM VIGSATAAAR NDTDAPTKMP SQPNTSLLSL
VLMSGTFFIA FFLRKLKNSR FLAGKVRRVI GDFGVPIAIL IMVLVDSAIP DTYTQKLAVP
DGFSVTSPDQ RSWLVNPLGV RSTFPVWMMF ACVVPAALVF ILIFMETQIT TLIVSKSERR
LVKGSGFHLD LLLIVLMGGA SALLGVPWLT AATVRSVTHV NALTVMSKAT APGEKPRIEC
VKEQRATGLL VAVLIGLSVV LGEVLRRIPL AVLFGIFLYM GVTSVNGIQM YDRLLLAFMP
AKHHPDSAYA SKVKTWRMNM YTAIQFVCLA LLWVVMSTAA SLAFPFVLIL TVPLRHFLLP
RIFTAHELRC LDSADAEPHV DEDDWQDEYA EVLMPV
//
