ID   S4RG29_PETMA            Unreviewed;       821 AA.
AC   S4RG29;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   SubName: Full=Lysine demethylase 1B {ECO:0000313|Ensembl:ENSPMAP00000004161.1};
GN   Name=KDM1B {ECO:0000313|Ensembl:ENSPMAP00000004161.1};
OS   Petromyzon marinus (Sea lamprey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX   NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000004161.1, ECO:0000313|Proteomes:UP000245300};
RN   [1] {ECO:0000313|Ensembl:ENSPMAP00000004161.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR   AlphaFoldDB; S4RG29; -.
DR   Ensembl; ENSPMAT00000004178.1; ENSPMAP00000004161.1; ENSPMAG00000003805.1.
DR   GeneTree; ENSGT00940000157751; -.
DR   Proteomes; UP000245300; Unplaced.
DR   GO; GO:0140682; F:FAD-dependent H3K4me/H3K4me3 demethylase activity; IEA:UniProt.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.30.40.100; -; 1.
DR   Gene3D; 3.90.660.10; -; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR002937; Amino_oxidase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR007526; SWIRM.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR011124; Znf_CW.
DR   PANTHER; PTHR10742; FLAVIN MONOAMINE OXIDASE; 1.
DR   PANTHER; PTHR10742:SF413; LYSINE-SPECIFIC HISTONE DEMETHYLASE 1B; 1.
DR   Pfam; PF01593; Amino_oxidase; 1.
DR   Pfam; PF04433; SWIRM; 1.
DR   Pfam; PF07496; zf-CW; 1.
DR   PRINTS; PR00419; ADXRDTASE.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS50934; SWIRM; 1.
DR   PROSITE; PS51050; ZF_CW; 1.
PE   4: Predicted;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          132..192
FT                   /note="CW-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51050"
FT   DOMAIN          273..371
FT                   /note="SWIRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50934"
SQ   SEQUENCE   821 AA;  91985 MW;  33476486520C4838 CRC64;
     MAAARPRGKR KAVVLEMITA NSMVRSSGRQ IKKKVPGGLE PEEDDEKRYR KCEKVGCMVT
     VPVCFVSASE RCAKNGYTSR WYHLSCGEHF CNECFDHHYR SHKDGYERYA SWKRVWTMNG
     KSEPSIKAFM ADQQLPYWVQ CTKPGCGKWR QLTREVMLTT ELAQTYCCGM KVNSAVKNEG
     FDPCAPPEDS RVVEVSEPRW FAMLLLPPLL KDSPAAPFLS AYYLDCVGMS PACAGTERCS
     GTNHSLPKIL VHYMFCVLPV PGLNPYFQPF YQPNESGKAL CVRPDVMELD ELYEFPEFSR
     DPTMYLALRN LILALWNMNC KEFLTVQKCM QHLLVRGLIR VRCMQELEGI LHFAMRKGLI
     NTGLLSAHPG RPLLPLHYRK NSVVVIGAGP AGLAAARQLH NFGLKVIVLE ARERIGGRVW
     DDRSLGGTTV GRGAQIVNGC VNNPISLMCE QLGIRMHVLG EACELLDESG RVTDPALDKR
     MDFHFNALLD IIAQWRTTTE PAHDVSLGAE KMEELTHAFR KESGLSFGEL EEKLLQFHLA
     NLEYACGANL RQVSARSWDH NEFFAQFAGD HTLLTAGYST ILHRLAEGLD VRLHTPVKRV
     DYSGECVKVH TATGMTYIAD KVLVTIPLAL MQLGVLEFCP PLPERKIKAL QSLGAGLIEK
     IGLQFPFRFW EHKIRGADYF GHLPPSHDRR GLFGVFYDMD PKGEQCVLMS VVSGDSVALI
     RDLSDSQVVS QSMQALRAIF PEQNVPDPLR WFVTRWGSDP WALMAYSYVR PGGTGEAYDV
     LAQDLNGKLF FAGEATNRHF PQTVTGAYLS GVREASKIAA S
//