ID S4RZP9_PETMA Unreviewed; 198 AA.
AC S4RZP9;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=DNA replication complex GINS protein PSF1 {ECO:0000256|RuleBase:RU368085};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000010690.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000010690.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Required for correct functioning of the GINS complex, a
CC complex that plays an essential role in the initiation of DNA
CC replication, and progression of DNA replication forks. GINS complex
CC seems to bind preferentially to single-stranded DNA.
CC {ECO:0000256|RuleBase:RU368085}.
CC -!- SUBUNIT: Component of the GINS complex.
CC {ECO:0000256|RuleBase:RU368085}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU368085}.
CC -!- SIMILARITY: Belongs to the GINS1/PSF1 family.
CC {ECO:0000256|ARBA:ARBA00006677, ECO:0000256|RuleBase:RU368085}.
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DR AlphaFoldDB; S4RZP9; -.
DR STRING; 7757.ENSPMAP00000010690; -.
DR Ensembl; ENSPMAT00000010736.1; ENSPMAP00000010690.1; ENSPMAG00000009724.1.
DR GeneTree; ENSGT00390000013968; -.
DR HOGENOM; CLU_079191_1_1_1; -.
DR OMA; NHLCMRR; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0000811; C:GINS complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd11710; GINS_A_psf1; 1.
DR CDD; cd21696; GINS_B_Psf1; 1.
DR Gene3D; 1.20.58.1030; -; 1.
DR InterPro; IPR021151; GINS_A.
DR InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR InterPro; IPR005339; GINS_Psf1.
DR PANTHER; PTHR12914:SF2; DNA REPLICATION COMPLEX GINS PROTEIN PSF1; 1.
DR PANTHER; PTHR12914; PARTNER OF SLD5; 1.
DR Pfam; PF05916; Sld5; 1.
DR SUPFAM; SSF158573; GINS helical bundle-like; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU368085};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU368085};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300}.
FT DOMAIN 20..111
FT /note="GINS subunit"
FT /evidence="ECO:0000259|Pfam:PF05916"
SQ SEQUENCE 198 AA; 23205 MW; 180833A6201EA4AD CRC64;
MFCEKAIELI RELHRATDAQ IPPFNEDGVR QVLEEMKVLY EQNQTDVNEV KSDGKNELIP
TIKFRHCCLL RNKRCLLAYA YDRVQRIRTM RWEYGSILPP SVRFHLSVEE QQFEWFNHYK
KSLASYMGSV GGEEGLDLTQ DTKPPKSLYI EVRCLKDYGE LEIDDGSTVL LKKNTQHFLP
RGRCEQLIRQ GILEHILS
//
