ID S4W9A7_9ASCO Unreviewed; 259 AA.
AC S4W9A7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Homocysteine hydrolase {ECO:0000313|EMBL:AGO87575.1};
DE Flags: Fragment;
GN Name=SAH1 {ECO:0000313|EMBL:AGO87575.1};
OS Dipodascus armillariae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Dipodascus.
OX NCBI_TaxID=43962 {ECO:0000313|EMBL:AGO87575.1};
RN [1] {ECO:0000313|EMBL:AGO87575.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBS 817.71 {ECO:0000313|EMBL:AGO87575.1};
RX PubMed=23786589; DOI=10.1111/1567-1364.12059;
RA Koufopanou V., Swire J., Lomas S., Burt A.;
RT "Primers for fourteen protein-coding genes and the deep phylogeny of the
RT true yeasts.";
RL FEMS Yeast Res. 13:574-584(2013).
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- SIMILARITY: Belongs to the adenosylhomocysteinase family.
CC {ECO:0000256|ARBA:ARBA00007122}.
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DR EMBL; KF042691; AGO87575.1; -; Genomic_DNA.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1480; Adenosylhomocysteinase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR042172; Adenosylhomocyst_ase-like_sf.
DR InterPro; IPR000043; Adenosylhomocysteinase-like.
DR InterPro; IPR015878; Ado_hCys_hydrolase_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23420; ADENOSYLHOMOCYSTEINASE; 1.
DR PANTHER; PTHR23420:SF0; ADENOSYLHOMOCYSTEINASE; 1.
DR Pfam; PF05221; AdoHcyase; 1.
DR Pfam; PF00670; AdoHcyase_NAD; 1.
DR SMART; SM00996; AdoHcyase; 1.
DR SMART; SM00997; AdoHcyase_NAD; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:AGO87575.1}.
FT DOMAIN 120..259
FT /note="S-adenosyl-L-homocysteine hydrolase NAD binding"
FT /evidence="ECO:0000259|SMART:SM00997"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGO87575.1"
FT NON_TER 259
FT /evidence="ECO:0000313|EMBL:AGO87575.1"
SQ SEQUENCE 259 AA; 28295 MW; 178C7EE9B40F9FE5 CRC64;
VTWSSCXIFS TQDHAAAAIA AAGIPVFAWK GETEEEYLWC IEQQLKAFKD DKQLNLILDD
GGDLTTLVHE KFPELLKDCY GVSEETTTGV HHLYRMLKDG KLKVPAINVN DSVTKSKFDN
LYGCRESLVD GIKRATDVMI AGKTAVVAGF GDVGKGCAXA LQXMGARVLV TEIDPINALQ
AAVSGYQVLP MEEACKXGQI FVTTTGCRDI ITGEHFSQMP NDAIVCNIGH FDIEIDVAWL
KANAKSVVNI KPQVDRYLH
//
