ID S4WB90_STRCH Unreviewed; 5532 AA.
AC S4WB90;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Type I polyketide synthase AVES 3 {ECO:0000313|EMBL:AGO88722.1};
GN Name=aveA3 {ECO:0000313|EMBL:AGO88722.1};
OS Streptomyces coelicolor.
OG Plasmid pZR695-p {ECO:0000313|EMBL:AGO88722.1}.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=1902 {ECO:0000313|EMBL:AGO88722.1};
RN [1] {ECO:0000313|EMBL:AGO88722.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=pZR695-p {ECO:0000313|EMBL:AGO88722.1};
RX PubMed=23710588; DOI=10.1111/1574-6968.12183;
RA Zhang R., Xia H., Xu Q., Dang F., Qin Z.;
RT "Recombinational cloning of the antibiotic biosynthetic gene clusters in
RT linear plasmid SCP1 of Streptomyces coelicolor A3(2).";
RL FEMS Microbiol. Lett. 345:39-48(2013).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; KC907349; AGO88722.1; -; Genomic_DNA.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd08956; KR_3_FAS_SDR_x; 3.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 3.30.70.3290; -; 3.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 3.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 3.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 3.
DR Pfam; PF21089; PKS_DH_N; 3.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF14765; PS-DH; 3.
DR SMART; SM00827; PKS_AT; 3.
DR SMART; SM00826; PKS_DH; 3.
DR SMART; SM00822; PKS_KR; 3.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 3.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 6.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 3.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00606; KS3_1; 3.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Plasmid {ECO:0000313|EMBL:AGO88722.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 37..464
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1766..1841
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1863..2291
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3566..3641
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3662..4090
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 5363..5438
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2295..2327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5532 AA; 575208 MW; EC7B2069D44A4057 CRC64;
MDTSSEKLVD ALRASLKANQ TLRARNEQLA AAMEASSEPI AIVGMACRFP GGVCSPEELW
ELVASGGDAI GEFPAGRGWD LEGLFDSDPD RSGTSYARYG GFLYEAGEFD ADFFGISPRE
ALAMDPQQRL LLETSWEAFE RAGIDPLSMR GSRTGVFAGV MYHDYGSRLG TIPEGFEGYI
GNGSGGAVAS GRVAYTLGLE GPAVSVDTAC SSSLVALHLA CQSLRSGECT LALAGGVTVM
STPHLFVEFS RQRGLSVDGR CKSFAGGADG TGMGEGVGML LVERLSDAVR LGHRVLAVLR
GSAVNQDGAS NGLTAPNGPA QERVIRQALA NAGLSVADVD VVEGHGTGTT LGDPIEAQAL
LATYGQRAGN RPLWLGSVKS NIGHAQAAAG VGGVIKMVMA LREGVLPRTL HVDEPSPQVD
WSAGAVRLLT EAVPWPGDAA GRLRRAGVSS FGVSGTNAHV ILEEAPAAGG CVAGGGVLEG
APGLAISVAE SVAAPVAVSA PVAESVPVPV PVPVPVPVSA RSEAGLRAQA EALRQYVAVR
PDVSLADVGA GLACGRAVLE HRAVVLAADR EELVQGLGAL AAGEPDRRVT TGHAPGGDRG
GVVFVFPGQG GQWAGMGVRL LASSPVFARR MQACEEALAP WVDWSVVDIL RRDAGDAVWE
RADVVQPVLF SVMVSLAALW RSYGIEPDAV LGHSQGEIAA AHVCGALSLK DAAKTVALRS
RALAAVRGRG GMASVPLPAQ EVEQLIGERW AGRLWVAAVN GPRSTAVSGD AEAVDEVLAY
CAGTGVRARR IPVDYASHCP HVQPLREELL ELLGDISPQP SGVPFFSTVE GTWLDTTTLD
AAYWYRNLHQ PVRFSDAVQA LADDGHRVFV EVSPHPTLVP AIEDTTEDTA EDVTAIGSLR
RGDNDTRRFL TALAHTHTTG IGTPTTWHHH YTHHHTHPHN HHLDLPTYPF QRQHYWLDAP
TGAGDVAAAG LEPAEHPLLA ATVQLADTDG CLLTGRLSLR SHPWLGDYEV GGAVLLSGSA
FVELAVQVGE RVGCTRIEQL TVHAPLVVPV GGGVSVQVGV AAADGEGRRL VSVYARGGSA
CGGGGASGGV WTCHASGVLV EAAAGGGVVV DGLAGVWPPR GAVAVDVDGV RDRLAGAGCV
LGPVFSGLRA VWRDGGDLLA EVCLPEEAWG DAAGFGLHPA LLDGVVQPLS VLLPGGTGFG
EGAGFGEGVR VPAVWGGVSL HRAGVTGVRV RVWAVGRGGG REAVSVVVGD EAGVPVASVD
RLELRPVDMG QLRAVSVSAG RRGSLYAVQW AEVGPVPVCG QAWAWHEDVG ESGGGPVPGV
VVLRCPDAGA GGGGGGGVGE VVGGVLGVVQ GWLGLERFAG SRLVVVTRGA VVAGQEDGPV
DVVGAAVWGL VRSAQAEHPD RFVLLDLDTD TDTGTDLDTG AGAGAGAGWG VDGGHVAAVV
ACGEPQLAVR GERVLAARLT RLESSVDVPA QRSGDVAGRE VLPWLSGGSV LVTGGTGVLG
AAVARHLAGV CGVRDLLLVS RRGPDAPGAE GLRAELAALG AEVRIVACDV GERREVVRLL
EGVPAGCPLT GVVHAAGVLD DATIASLTPE RLGTVFAAKV DAALLLDELT RGMELSAFVL
FSSAAGILGS AGQGNYAAAN AALDALAYRR RAAGLPGVSL AWGLWEEASG MTGHLAGTDH
RRIIRSGLHP MSTPDALALF DAALALDRPV LLPADLRPAP PLPPLLQDLL PATRRRTTRT
TTTGGADNGA QLHARLAGQT HEQQHTTLLA LVRSHIATVL GHTTPDTIPP DRAFRDLGFD
SLTAVELRNR LSRTTGLRLP TTLAFDHPNP TTLTHHLHTQ LLGSDSTASI PAPRAAAVPA
DQDEPVAIIG MACRYPGGVT SAEELWELLA SGRDTVGEFP TDRGWDLEAL FDPEPGRPGT
SYTRCGSFLY DAGEFDAGFF GISPREALAM DPQQRLLLEA SWEAMEQAGI DPTTVRGSQT
GVFAGLIPQA YGPRLHENAA ADTEGYVLTG TSGSVASGRI SYTFGFEGPA VSVDTACSSS
LVALHLACQA LRAGECSMAL AGGVTVMSSP GAFVEFSRQR GLAADGHCKA FSAAADGTGW
GEGVGMLLVE RLSDARRNGH RVLAVVRGSA VNQDGASNGL TAPNGPSQQR VIRQALANAG
LSAGDVDAVE AHGTGTTLGD PIEAQALLAT YGQDRAGEGP LWLGSVKSNV GHTQAAAGVA
GVIKMVMALR NGLLPRTLHV DEPSPHVDWS AGAVQLLTET VPWPGGEGRL RRAGVSSFGV
SGTNAHVILE EAPAHNIPSD TPADDVPGGP PAGEDAGSGE EAAAGSPGVW PWLVSAKSQP
ALRAQAQALH AHLTDHPGLD LADVGYTLAH ARAVFDHRAT LIAADRDTFL QALQALAAGE
PHPAVIHSSA PGGTGTGEAA GKTAFICSGQ GTQRPGMAHG LYHTHPVFAA ALNDICTHLD
PHLDHPLLPL LTQDPNTQDT TTLEEAAALL QQTPYAQPAL FAFQVALHRL LTDGYHITPH
YYAGHSLGEI TAAHLAGILT LTDATTLITQ RATLMQTMPP GTMTTLHTTP HHITHHITAH
ENDLAIAAIN TPTSLVISGT PHTVQHITTL CQQQGIKTKT LPTNHAFHSP HTNPILNQLH
QHTQTLTYHP PHTPLITANT PPDQLLTPHY WTQQARNTVD IATTTQTLHQ HGVTTYIELG
PDNTLTTLTH HNLPNTPTTT LTLTHPHHHP QTHLLTNLAK TTTTWHPHHY THHHNQPHTH
THLDLPTYPF QHHHYWLEST QPGAGNVSAA GLDPTEHPLL GATLELAEGD GCLLTGRLSL
RTHPWLAGHA VGGVVLLPGT AFAELALHAG ESVGCDHVDE LTLHTPLVIP EVGDVTLQVA
IAAPDESGRR MMTIHSRGEG GSGGADASAS AWTRHAAGVL SPAKDDDTAS YELLAGPWPP
VGATPVDLNT AYDQMADAGF AYGLAFQGLR AAWRYGDDIL VEARLPEEVS GDAAAYGLHP
ALLDAALQGT GLLSVAGPGT PVVPHVWNGL RFRTHGAVSV RACLSTLGAT GAAVCVRITD
DTGVPVASVD RLELRPVDMG QLRAVSVSAG RRGSLYAVQW AEVGPVPVCG QAWAWHEDVG
ESGGGPVPGV VVLRCPDAGA DGGGGGGVGE VVGGVLGVVQ GWLGLERFAG SRLVVVTRGA
VVAGPEDGPV DVVGAAVWGL VRSAQAEHPD RFVLLDLDTD LDSGADADAG NEAGMGSGLD
GGRVAAVVAC GEPQLAVRGE RVLAARLTRL ESPVDVSGRE VLPWLSGGSV LVTGGTGVLG
AAVARHLAGV CGVRDLLLVS RRGPDAPGAE GLRAELAALG AEVRIVACDV GERREVVRLL
EGVPAGCPLT GVVHAAGVLD DATIASLTPE RLGTVFAAKV DAALLLDELT RGMELSAFVL
FSSAAGILGS AGQGNYAAAN AALDALAYRR RAAGLPGVSL AWGLWEEASG MTGHLAGTDH
RRIIRSGLHP MSTPDALALF DAALALDRPV LLPADLRPAP PLPPLLQDLL PATRRRTTRT
TTTGGADNGA QLHARLAGQT HEQQHTTLLA LVRSHIATVL GHNAPEMIPV DSAFRDLGFD
SLTAVELRNR LGEATGLRLP TSLVFDQPNA ATLARHLRRE LMGDDAEGET PSQVALHQVA
ADEPIAIVGM ACRFPGGVCS PEELWELVAS GGDAIGEFPA GRGWDLEGLF DSDPDRSGTS
YARYGGFLYE AGEFDADFFG ISPREALAMD PQQRLLLETS WEAFERAGID PLSMRGSRTG
VFAGVMYHDY AARLHHVPEG FEGLIANGSA GSVATGRVAY SFGLEGPAVT VDTACSSSLV
ALHWAAQALR AGECSMALAG GVTVMSSPGT FVEFSRQRGL AADGRCKAYS AAADGTGWAE
GVGMLLVERL SDARRNGHRV LAVVRGSAVN QDGASNGLTA PNGPSQQRVI RQALANAGLT
PADVDAVEGH GTGTTLGDPI EAQALLAAYG QHRPHHRPLW LGSLKSNIGH AQAAAGVGGV
IKMVMALRNG LLPQTLHVDE PTPQVDWSTG AVQLLTQPVP WPADPAGRPR HAGVSSFGVS
GTNAHVILEE APAAAGGAAG GGVSVGAPNP ALPVAESEPV PVPVPVSARS EAGLRAQAQA
LRQYVAARPD MSPADIGAGL ARGRAVLEHR AVILAADREE LAQALTALAA GEPHPHITTG
HTRGSDRGGV VFVFPGQGGQ WAGMGLTLLT SSPVFAEHID ACEKALTPWV PWSLTDILHR
DPDDPAWQQA DVVQPVLFSI MVSLAALWRS YGIEPDAVLG HSQGEIAAAH ICGALSLKDA
AKTVALRSQA LAAVRGRGAM VSLPLPAQDV QQLISERWEG QLWVAALNGP HSTTVSGDTT
AVEELLTHCA DTGLRAKRIP VDYASHCPHV QPLHDELLHL LGDITPQPST MPFFSTVVGH
LVWYTTTLDA AYWYRNLHQP VRFSHAIQTL TDDGHRPFIE ISPHPTLVPA IEDTTENTTE
NITATGSLRR GDNDTHRFLT ALAHTHTTGI RTPTTWHHHY TQTHPHPHNH HLDLPTYPFQ
HQHYWLQPPT TTTDLTTTGL TPTHHPLLTA TLTLANNNTQ LLTGRLSLRT HPWLTDHTVV
GTTLVPGTAL LELALQATTT DHLEELALHT PLVIPREGAV DVQVHINPPD DTDTRSLTIY
SRSENAPAAA PWRHHATAVL GTKTSRIETG RSHDDLSMWP PAGAVRCADE ELAALYGDYE
ANGFVYGPAF RGLTAAWRLG DEVFAEVRLP EQVHGEASAY NLHPALLDAA LHAAAFAPSG
SLPQGSVPFS FTGVTLHAAN ASSLRVRLSP ADPNSGHAAV SVLVTDDTGT PVASVEALAV
RPLAADELRA AERAVQRAEL FDMKWVEVPS DVLVSGGASV VVLDGADDLV GLAAEEDGVP
GVVVLRCPDA GADGGGGGGG VGEVVGGVLG VVQGWLGLER FAGSRLVVVT RGAVVAGPED
GPVDGPVDVV GAAVWGLVRS AQAEHPDRFV LLDLDTDLDS GADRDAGNEA GMGSGLDGGR
VAAVVACGEP QLAVRGERVL AARLTRLESP VDVSGREVLP WLSGGSVLVT GGTGVLGAAV
ARHLAGVCGV RDLLLVSRRG PDAPGAEGLR AELAALGAEV RIVACDVGER REVVRLLEGV
PAGCPLTGVV HAAGVLDDAT IASLTPERLG TVFAAKVDAA LLLDELTRGM ELSAFVLFSS
AAGILGSAGQ GNYAAANAAL DALAYRRRAA GLPGVSLAWG LWEEASGMTG HLAGTDHRRI
IRSGLHPMST PDALALFDAA LALDRPVLLP ADLRPAPPLP PLLQDLLPAT RRRTTRTTTT
GGADNGAQLH GRLAGQTHEQ QHTTLLALVR SHIATVLGHT TPDTIPPDRA FRDLGFDSLT
AVELRNRLSH TTGLRLPTTL AFDHPNPTTL THHLHTQLVS KGLTAAAEPD AATTPPGLPS
LLSELERLEA VVLSSTTSSA APLDDGARTR LASRLHSLAQ KLNGDDTAPD LAETSDEEMF
ALIDREVGFE SQ
//
