ID S4XG05_SORCE Unreviewed; 1585 AA.
AC S4XG05;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Fis family transcriptional regulator {ECO:0000313|EMBL:AGP32062.1};
GN ORFNames=SCE1572_02460 {ECO:0000313|EMBL:AGP32062.1};
OS Sorangium cellulosum So0157-2.
OC Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae; Sorangium.
OX NCBI_TaxID=1254432 {ECO:0000313|EMBL:AGP32062.1, ECO:0000313|Proteomes:UP000014803};
RN [1] {ECO:0000313|EMBL:AGP32062.1, ECO:0000313|Proteomes:UP000014803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=So0157-2 {ECO:0000313|EMBL:AGP32062.1,
RC ECO:0000313|Proteomes:UP000014803};
RX PubMed=23812535; DOI=10.1038/srep02101;
RA Han K., Li Z.F., Peng R., Zhu L.P., Zhou T., Wang L.G., Li S.G.,
RA Zhang X.B., Hu W., Wu Z.H., Qin N., Li Y.Z.;
RT "Extraordinary expansion of a Sorangium cellulosum genome from an alkaline
RT milieu.";
RL Sci. Rep. 3:2101-2101(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; CP003969; AGP32062.1; -; Genomic_DNA.
DR RefSeq; WP_020465200.1; NC_021658.1.
DR STRING; 1254432.SCE1572_02460; -.
DR KEGG; scu:SCE1572_02460; -.
DR PATRIC; fig|1254432.3.peg.541; -.
DR eggNOG; COG0515; Bacteria.
DR eggNOG; COG2203; Bacteria.
DR eggNOG; COG2204; Bacteria.
DR eggNOG; COG2909; Bacteria.
DR HOGENOM; CLU_003631_0_0_7; -.
DR OrthoDB; 9802322at2; -.
DR Proteomes; UP000014803; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR002197; HTH_Fis.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR002078; Sigma_54_int.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR025944; Sigma_54_int_dom_CS.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR32071; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR PANTHER; PTHR32071:SF95; TRANSCRIPTIONAL REGULATORY PROTEIN ZRAR; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF02954; HTH_8; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00158; Sigma54_activat; 1.
DR Pfam; PF13424; TPR_12; 1.
DR PRINTS; PR01590; HTHFIS.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 11..278
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1250..1479
FT /note="Sigma-54 factor interaction"
FT /evidence="ECO:0000259|PROSITE:PS50045"
FT REGION 992..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1498..1537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1192..1222
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 40
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1585 AA; 169329 MW; 81056BEA40A4E317 CRC64;
MTSHPLFPPR YEPIGTLGKG GGGEVWAVRD RITGKTVALK TLGEDADEPE VLALVREAAA
LSGVEGLGVP RVLRFGRLPA SGRPFMVREL VEGTSLADLL ARKGDLARNL AAIADAADQL
TRLHRALLLH GDVKPANIIV GEGGRATLVD LGLATPFRDD GSRPVGLTPR YAAPELFKGD
PLTVRAEVFA LGATLAEALR QSEGEGARDP KVIGALQEVV DRATAREPNA RYPSADELAN
ALRRAARLPC GPSEEPAGPA EPGARPDAGA GAVVWPIVGL DAPSGRLLAQ IMALPAGSGL
SIAGPPASGR SALLRRIAWS LEVGGYAVAW VEAARVADPR EALAIELSAH DPGRVTALVD
DADRLGDAEI ERLDEVRRAG GKLVLVLGDP RERGAGGADG APAAGAPSPG RAAAFARGFQ
RFEMAPLDEQ VARELVQRTI PSLSDAVAAH VVARAGRWPG RIREIVARIA RAPVASTEDV
DRLLEAPPAS GAAASGPGGA GAEGAALPPA EIHRLLDRGH FDAAAEALGR LQGDGSPVVV
PVVVIARARL AMNRGDTARA LAELARAKDQ VEASGDRAQA AFWSLQMARA LLRTGDYGEA
ERRAGEAVER LGPLKLEAEL PGEPRPELAT AAAFGASPEA IVAEAVATRG LAQSFASRHE
DAKRTLEHAV RLARLTGEPR ILSVALVSLA FALQRDDRLS EAKAVYEEAL TAAEQAGDAG
TLATTRLNLA ALTKLQGDLG AAIRHLEAAV DLGRRSGRVT TIRQALLNLA NLDLYLGRLA
RARVSLDALA AQRADLAQQQ HAQLLALEAE HAARSGDLEQ AERLCLECAE AYEAMGRRID
GVEARLERVL FAVARAGADP RALGEEIDVA AERLGTTGAH RALLALARGR VAALARDERR
ARAAYDEALE AARAAGQRDW IWRALEARAQ LETERGHLIR ARHDREEALI TLEEIASKLP
RDLREVFWND ARRKEIRAAA MLELMSSRTV PFAQPGAGPA PGAGSTQGAA SQAAAAPPPG
EDRLARVLEI NREIAGEHDL TRLLAKVTDH AIALLQAERG FIILQRPPRG EPPPAAGEGA
VDLSIHASRD QAGDDPHARF SSSIAERVIS TGEPVVTASA RDDARMSDYV SVHQLMLQSV
ACVPIRQRSG QVIGALYLET RLSAAAKFEA ELPTLTALAD QVAIAIETAR LVGENERRAR
ELERANEELR AARAKLEELL GHRTAQLAAT RRDLRSARAV IRGHFGYEGL VGTSEAMRRV
YALIDRVKDT DIPILITGES GTGKEVVART IHNASPRAKK PFVGVNCGAI PEHLLESELF
GHVRGAFTGA DRDRKGLFRE VTGGTILLDE IGEMPQKMQA GLLRVLQEKV VRPVGGAREE
PVDARVIAAT HRDLADMVSR GTFREDLYYR LHVVEVRVPS LRQRIEDIPL LIDYFLGIFA
ARYGRDRRSV SRAALKRLSA YSWPGNVRQL ENVLLNAWVL SDRPELESDD FELPDAAPRS
LRGAEAPPPT RAPLGGGGAP ASAGRAPPSS EPLRVETSLD AHKASERERI LVALSSCNWN
RVKAAQVVGL PRRTFYRRLK EYGIQ
//
