ID S4XKK3_SORCE Unreviewed; 5967 AA.
AC S4XKK3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:AGP33712.1};
GN ORFNames=SCE1572_03900 {ECO:0000313|EMBL:AGP33712.1};
OS Sorangium cellulosum So0157-2.
OC Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae; Sorangium.
OX NCBI_TaxID=1254432 {ECO:0000313|EMBL:AGP33712.1, ECO:0000313|Proteomes:UP000014803};
RN [1] {ECO:0000313|EMBL:AGP33712.1, ECO:0000313|Proteomes:UP000014803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=So0157-2 {ECO:0000313|EMBL:AGP33712.1,
RC ECO:0000313|Proteomes:UP000014803};
RX PubMed=23812535; DOI=10.1038/srep02101;
RA Han K., Li Z.F., Peng R., Zhu L.P., Zhou T., Wang L.G., Li S.G.,
RA Zhang X.B., Hu W., Wu Z.H., Qin N., Li Y.Z.;
RT "Extraordinary expansion of a Sorangium cellulosum genome from an alkaline
RT milieu.";
RL Sci. Rep. 3:2101-2101(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|RuleBase:RU003707}.
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DR EMBL; CP003969; AGP33712.1; -; Genomic_DNA.
DR STRING; 1254432.SCE1572_03900; -.
DR KEGG; scu:SCE1572_03900; -.
DR PATRIC; fig|1254432.3.peg.859; -.
DR eggNOG; COG0236; Bacteria.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1028; Bacteria.
DR eggNOG; COG2226; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_222993_0_0_7; -.
DR Proteomes; UP000014803; Chromosome.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 2.
DR CDD; cd06558; crotonase-like; 1.
DR CDD; cd08953; KR_2_SDR_x; 2.
DR CDD; cd00833; PKS; 4.
DR Gene3D; 1.10.1240.100; -; 4.
DR Gene3D; 3.40.47.10; -; 4.
DR Gene3D; 6.20.390.20; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR049490; C883_1060-like_KR_N.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF21394; Beta-ketacyl_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 4.
DR Pfam; PF00109; ketoacyl-synt; 4.
DR Pfam; PF02801; Ketoacyl-synt_C; 4.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF08242; Methyltransf_12; 2.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 5.
DR Pfam; PF14765; PS-DH; 2.
DR SMART; SM00826; PKS_DH; 2.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 4.
DR SMART; SM00823; PKS_PP; 5.
DR SMART; SM01294; PKS_PP_betabranch; 4.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR SUPFAM; SSF53901; Thiolase-like; 4.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
DR PROSITE; PS00606; KS3_1; 4.
DR PROSITE; PS52004; KS3_2; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 3: Inferred from homology;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..66
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 175..614
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1491..1568
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1618..2042
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2757..2834
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2903..3331
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3827..3903
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4003..4425
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 72..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1460..1491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2220..2241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2874..2896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3916..3942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5759..5798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5896..5936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5967 AA; 637190 MW; 2E5F76EE1DB1ED8B CRC64;
MAAEILKLDI DEVNLRQPVV DYGLNSVLAT EFIERFERRF GIRLAPTVFF EYQDLHSLAN
HLVERYPDRI ERALDTDRST PKPAPPRGTG TANGAAASDA SALGRTRHAQ PSASGAGAPM
SDLEALWGGE GQETTPGELA SADAPTPDAG ERAPAGAAPS QRGEHAPVGA APSQRDDVAV
IGLCAVLPAS ADIEAFWAHL LAGDTLITRI PAERITAGTY HPAPIGGGRR SDVAWGAFLD
GVDAFDAAFF GITPREAELM DPQQRLFLQT VWHVIEDAGY DPRGLANSRT GVFVGVATTD
YLDLAMEAGV APDAYMATGL AHSILANRVS FLLGLSGPSE PVNTACSSSL VAIHRAVESI
RAGECDMAIA GGVNLILHSR VSDAFQRAGM LSPTGRCNAF AAGADGFVRG EGVGAVLLKP
LRKARADGDP IRGVIRGSAI NHNGRSGTLI APRLDAQVDV LLRAYMNAGV DPSTVGLIEA
YGIGADLADQ VEILALKRAF DELYQRWGLP APKRPHCAIG SVKTNVGSLE TASGMASLAK
VLLAMKHAQL PRNANASASA INPHIDLSGS PFYLLDRTTA WPSSVDPRAE RAPRRAGISA
FGYGGVNAHV VVEEPDAPEA MVNAEAGPRI LVLSARTEER LRVYASRLAR SLRRDIETGS
APALRDLAFT LQVSRASWEC RAAAVVRDLA SALDALDAIA SGEARTAGVL LGEVPKRTVK
SAVTDPSSAE QEEHAALVAD RQWKALARRW VEGESVAWTR LYADEPAPRR VSLPGYPFDG
RRHWLFERGE AGRLKPKDEG ARVGEGAIQD AHRGDASASG GAAQVDESRE LLRTVYRAED
TARRGHTVRG VGVVPASTLI ERTFAAASAL SAARCALERI VFLRPVSCAR GEVSVRVVAA
QRERGWEFEI QDDPGAVYAR GVIALGEGGP MPQPLPLDEI EQRCADELSA TQLYRALSDA
GIEYSLDLRA LTRVGRGPGE ALGRYRVDRA SPAPEALLGA VFEGAIQTLA AVLSTTSSRM
VFSLGRVEVW RGPGRSGWTY AQRTSDERFD VIVTDDVGAI CIRLLDVALR APAVSAREEA
ADGAEPLAAP SSLQAALSPA RSRLGAVDAA AHVGALAKLE SFAQRLLLHA LRGAGIDPSR
EGVDRDAIRR ALGVTPARER LLSALLNAVR TANAPAAEHA WDPALEAERL AAESPSIAAH
LAFLTRCAAH LVAVLRGEVT PTEVVFPGGS SHLVEAVYGD SPLTVPFNEA VATAVRTFVA
QRASAESPDR RVRIIEVGAG TGGTSVPVLE AIEPWRRSVE YVYTDISRGL LRRAEERIGA
TRSFVRFAVL DIEQDIEQQG FQAGRFDVVI AANVLHATRD IEQAVGHARD LLGPGGWLVV
SEATSPQLFL TMTFGLLDGW WRSEDDRRSP DGPLLGLGGW QELFRDLGFS AVSALTAPAP
GGAEPHQAVL IAESDGRIAR PSAPRPAEAR QPHAAARAGR QAVGPRARGP EAAEPIVREL
VAQICAALRM KPDDVDVHQP FADYGVDSII AVELVERVNR ILGTKVFPTA LFEHNNILAL
AARLAEELAD APHTGAVGAG AGAVAPADVG GPGVASDTAI ATQAGGNAAR ATGAKAPDGL
IAVIGMSGRF PGARNLAEFW RLLASGTCAI RKAPKERWAA EEIFDPDPDR LDRSYCVEGG
FLDDVDLFDA AFFGISGREA ELTDPQHRLF LEEAYAALED AGYATESIRG ARCSVFVGAG
AGDYLNRMLE LRLPKGAQAF WGNTASVLAS RLSYFLDMKG VSLAVDTACS SSLVAVHLAC
QSLLDGESDL AIAGGAFLNV TPNFHILASN ARMLSPVGRC KAFSADADGF VPGEGVGAVV
LKRLDAALRD GDCIHGVILG SAVNQDGRTN GIIAPSVESQ AALLRDVYDR NGIDPATITY
VEAHGTGTRL GDPIEVEGLT RAFRQSTDAQ GYCALGSVKT NIGHAATAAG IAGLLKGLLC
LRHGQIPPSL HFSAPNPAID FGASPFFVNT ELREWSRDRR PRRMTVSSFG FGGTNAHLVL
AEPPERPLRP AARKPAAYVV PLSAKHPDAL CRRISDLGRW LKGQALLHDL RDVVHTLQRR
RSHHAHRAAF VVRDAQELLE AIRAVEQEGR HPRALTSEGR GSVTGLRRSL DELAASLCRE
LGDGALPPDE QDKKSVALAE LYVVGTDIDW ERAYPDEGRA VSLPTYPFVR QRFWAEPPAE
ALPRAAEAPR PRPPATDDGR RVAYFGPRWD RAPLQIATAR AWQGGDLVVF DLDAQLVREQ
RARGLDGARR ILWVRPGARF DISAPDAIAV DPSSPDDYRQ LWAHLAGPGS APAALVLLWP
WRLSARAGAD AGDVERALAH GIRAIELLAR AMCGAPPAAE TRLVLVHRGD LEVRAGDQPL
GEAAAAYGRS LRPLLPQVRF LSLMLPGDLD ERRLADLLDR ELSDAGGDPH REVAYDGGER
YVRGLGPAEP IPSEDGAALR ERGHYLITGG AGGLGRIFAR HLARRCQARL LLLGRSPLDE
RLRAELTSLE ELGAEIMYHQ ADVTRARDLE GALAEAKRRF GPLHGVIHAA GVITGRLLTD
KSHAEFEATL RPKIAGTPAI DAVTAGEPLD FFVAFSSASS WLGDMGQGDY AVANRFMDAY
CLHREGLRRR GLRRGRSVSI AWPLWRDGGM RFAPDLEQRY LRSSGLTLVE ERHGIEAFEA
ILAGGPVQVM PLVGDLSLLA PILGLSAPRA KPSFNAAAVD GVAREAPAGG RGGAAGPARE
QIEADLRKSI AAHFKVNIGE LELDDHLGAL GFDSLMLTEL ADRMSRRYGV EVLPTVFFSH
NTVRSLAAHL VEAFGPGLRL EESPPQAARG AEVSASPLEA PLAAAGEAPV GREAPAVREA
PSGAPGSEPS AIGRARQGSD IDGNAIAIVG MSGVFPGARD LDELWEHLVA ERDLITEVPP
ERWDWRAHFG AERGQSTSRW GGFIADVDRF DAAFFRISPL EAKLMDPQQR LFLEHAWKAI
ESSGHRASEL AGRAVGVFAG VQFNDYQMLL SSRADYRAQV ITGNAHTMVA NRVSYALDLH
GPSEAIDTAC SASLVALNRA VRALRAGECE AALVGGVSLM LAPSTMIGAS QLEVLSPRGR
CRTLDAGADG FVKGEGVGVL FLKPLSAALA DGDPIHAILR GAAVNHGGRA HSLTAPNADA
QAALLQAAYK DAGVAPETVT YIELHGTGTK LGDPVEVEGL KKAFGRTSAA GAGPTCGLGS
VKANIGHLEP AAGIAGVIKV VLSMRHGVLP GNPHLVELNP YLQIEGTPFY AVERMRPWQR
LADPGGSPVP RRAGVSSFGF GGANAHVVLE EHVQTPAASA SGRAGPELIL LSAREEERLR
DAVAALAAYL ERRRARGGEA LPSLRDIAFT LALGREELEW RLALAAGTHE ELIEKLRAAL
GADPSCPGVH RGHVSRRTLP AESDGAAALH ALAERDLDTL ARLWTGGARI ALPALFEGEP
RPRRVSIPTY PFRGPRYWFD TSSSVDRGRS DGDGKPELAP AADPTFAEVW ERRARSYQGD
EVTLKVVDGS IAWIEMNDVT HRNMFSEGLV LGLLARFREI QGRADIKAVV LAGGGNVFMM
GGTEDGLIDI ADGNAKYSDL PFLYEGLLRC EVPVIAAMQG HALGAGLCFG LYADVVVMAE
EAIYGANFMS YGFTPGLGAT YILAERFGNP LATEMMYVAR SFTGRELKER RSSPIFRPAA
EVHAEALAIA RRLADKPRES LVILKQELAG RTLAALPRVI AAEIEMHRQT FAIPEVRERI
REHFAKASLQ PIAAAGQPAA PEVSASAAAA AAPALSTAAP PASVAADAIT AILRRLRSVL
SDALQIEDEV DAELPFQEMG VDSISGVEII RDINRTFGLN LEAIALYDHP TLNALAERVR
AELVKAGRPL LGELSGQEAA APPASHAAAS SEQATPAEPA RSAVALPPSA LATPAAPTAA
AAAGVAEIDV EHAGTTVAKA VSSERASAER AASIDGGATV TTAADVAIIG MAGRFPGAPD
RDRFWHNLAH GVDSVTEVPP ERFDVARVFD PDPRAAGRTY CKWGGFLTDI DRFDAEFFHV
SPKEAEMMAP EQRLFLEESW RALEDAGYSD RRLAGSRCGV FVGASARDYV ERARGRKTAH
ALTGLSNSVL AARIAYHLDL KGPAIAVDTA CSSSLVAIWL ACQSLLAGEC TMAIAGGVTL
MLSPDFLIVS SNASVLSPTG KCATFSSAAD GIVMSEGVGV VVLKPLARAL ADRDHIHAVI
KAVGANQDGK TNGISAPSAR SQTVLELDVY RRAGIDPDQI SYVEAHGTGT PLGDPIELKA
LKDAFSAYSA ERARCPIGSV KTNIGHANMA AGVASVIKVA LAMRNRQIPP SLHFGEPNPH
IDFGSSPFYV NTALTPWERR SDGPRLAALS SFGFSGTNAH AVLAEPPAPE RHGARSRPHL
VVLSAKSEAA LRRRLEDLFG WLGRQGDDLW LGDVSFTLGA GRSHFELRSA FVVRDPGELR
ASLEAALAGK AQPHARRGDV PSDHAKVREA RARGARAQDA CARAEGSEDR RRQALLEMAE
AYVGGYDPDW EAIFADEDAL RIPLPTYPFQ GERYWIDDEE QRSSAPAAHA ASHPLIDGAD
WRGSLGEGLV FRKTFSPDDP VVRDHRVQGQ AILPAVAYLE LVLAALAAAG AEAAWALRRV
RWLRPLAVGD LVEVQVRLRD DKGQIRFEVT SGKSEERHVH AQGDLCAADP APPRSVDLDG
IRRRCARRLA HDEIYAQYAA LGIVYQGDYQ ALAEVSGNRR EALGVLRLPA EAEGRERYRL
DPALADAALQ AISGFVLDAQ EGQALLPFSA EEVEVYRPVG AGGFSYLELA GERRFHVTLL
DLEGNVCAVL RDISLRPWRD PLADFFYTPR WVEQPHAEAL PQQRAAMRSV LVIHADERLG
LKESVAALHP GAVIAEVVVG ARHRRRAPDS VEIPAEDPKG YTAALEDLLT RVGSIDCIYF
LASLLPPGRS AGDLREVQER SVIALFRLIK GLIDAGLQRE PLRLAVATND VHPVTGKEAL
DARAAGVHGL TKAISKELSG WDVSCVDVSL EGVRPAAGPD PWGALLAELS REPRQRGGED
VAVRDGRRFV RAIEKVTLAP RPEAPLRRGG VYLILGGAKG IGLALSRDLA ARFSARLVWI
GRSPLDAERR RDMDEIRRAG GEVLYLQADA TDRRAMDEAI QRARQRFGRI DGAVHSAIVL
EDRSLLRMTE GELRAVLGPK VDGAVNLVEA LAGDALDFLV FFSSAQSFAG SAGQGNYAAA
STFEDAFAHA VARRAPFPVR IINWGYWGTV GIVANAEVAT RMSAMGIGSI RPEEGAEAFR
RILAHDLVQV MAIRADKRVG ERLDLLQSDG SEGRDGGRGP AAPPSWVDRV VERTVLPAID
AGVVQRYEAA ATAIERLTAR MLWQTLVQAG ALPPGPAHLR RDELRERLRV LEGYRRLFDA
SLDVLARAGY LRLAGDAVEV LRAPDGAEPR LEEARVRILE EHPEARAAVS LLDVCVDAFP
AVVSGEKDHM AVLFPGGGMS RVEGIYRGNA VIDYFNRVTA SAVEAYVRAR LADDPSGTVR
ILEVGAGTGG TTAFVLEALK PHAAAVRYLY TDVSRGFAEF GRSRFAAAYP FVEFEVVDAE
RASLTPVVQP GTVDVVLASN AIHATRRIGR TLGEIRALLR PGGLLVLNEG CRRRDFATLT
FGLTSGWWLY EDERLPWAPL LSVAGWERVL RESGFSATRA LALPGVRPED AAQVVLVSER
DPASPRQEEA RPAVAPATAA RGAEPAGEPA RPAASAAVSD KGLHGRALEY VTRVLGEVLK
SDGAKIRPDA TLERYGIDSL ISQEINARFE RDLGPLPATM LFEHNTAERL SAYLLAEHRG
ALARVLGLTS GEAAAAHEGA ADQGRGARAD ATPPEPRGGG GQYARDSAAP SGDVRRRIAQ
LSDQQVESLL NSLIHTNPTL NGGRSRW
//
