ID S4XYT6_SORCE Unreviewed; 2035 AA.
AC S4XYT6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011};
GN ORFNames=SCE1572_30225 {ECO:0000313|EMBL:AGP38387.1};
OS Sorangium cellulosum So0157-2.
OC Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae; Sorangium.
OX NCBI_TaxID=1254432 {ECO:0000313|EMBL:AGP38387.1, ECO:0000313|Proteomes:UP000014803};
RN [1] {ECO:0000313|EMBL:AGP38387.1, ECO:0000313|Proteomes:UP000014803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=So0157-2 {ECO:0000313|EMBL:AGP38387.1,
RC ECO:0000313|Proteomes:UP000014803};
RX PubMed=23812535; DOI=10.1038/srep02101;
RA Han K., Li Z.F., Peng R., Zhu L.P., Zhou T., Wang L.G., Li S.G.,
RA Zhang X.B., Hu W., Wu Z.H., Qin N., Li Y.Z.;
RT "Extraordinary expansion of a Sorangium cellulosum genome from an alkaline
RT milieu.";
RL Sci. Rep. 3:2101-2101(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; CP003969; AGP38387.1; -; Genomic_DNA.
DR STRING; 1254432.SCE1572_30225; -.
DR KEGG; scu:SCE1572_30225; -.
DR PATRIC; fig|1254432.3.peg.6824; -.
DR eggNOG; COG0515; Bacteria.
DR eggNOG; COG1672; Bacteria.
DR eggNOG; COG2319; Bacteria.
DR HOGENOM; CLU_002352_1_0_7; -.
DR Proteomes; UP000014803; Chromosome.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd14014; STKc_PknB_like; 2.
DR CDD; cd00200; WD40; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 5.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR049052; nSTAND1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19848:SF8; E3 UBIQUITIN-PROTEIN LIGASE TRAF7; 1.
DR PANTHER; PTHR19848; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF20703; nSTAND1; 1.
DR Pfam; PF00069; Pkinase; 2.
DR Pfam; PF00400; WD40; 18.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00220; S_TKc; 2.
DR SMART; SM00320; WD40; 18.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 3.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 18.
DR PROSITE; PS50294; WD_REPEATS_REGION; 18.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 7..284
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 377..665
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 1231..1263
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1273..1305
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1315..1347
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1357..1389
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1399..1430
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1441..1472
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1483..1515
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1525..1557
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1567..1598
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1609..1641
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1651..1683
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1693..1725
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1735..1766
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1777..1808
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1819..1850
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1861..1892
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1903..1934
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1944..1975
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 219..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 406
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 2035 AA; 219450 MW; 36D8ECF4BF604AB7 CRC64;
MMFQGRYELL SVLRESSLGT VYQGRQVETG QPIALRLMRL DRGGDPADPE DLARSLQEMR
RCARLHHPNI TRPIDWGQAD EGHVFTVSEL VPGQSLAELL SQQGALDPQE ARHLMRQVLD
ALACAHRQGI AHGALRPTHV MLVPSAAARR DARVLDFGVA AVAASLRSGR GGGPASGTEP
LGSLAYAAPE QIWGPAPTAR SDLYAWALMF LECLTGRRAH RASPPDGPPD GPPDGDDVQH
QDRGPVRIPP ALLGHPVGAI VRRATSEEAD ERLVTAEGLL RELDACEPGG LRRAALVDLG
APLGAETAES PGSRPPARPP PQPAAGALPE AVDTPEMSGA ALPAEEAPTT PADALATPGD
ALAAYAPPNV GDTIKHYEII RKLGQGGMGV VFLARDTRLG RLVAIKLLRE HSRQGIGRFL
AEARATARCR HENIVVIHEV DEIHGHPYLV LEYVKGRTLR EWMSQREHPS ASGSPIAHTP
PGPLSPSLAV ELMIPVVRAL ACAHELGLVH RDLKPENIVL EDTGSIKVLD FGIAKQIEAE
RISVFTGVRM VLAGGARPSA QSTILGTPRY MSPEQLRGAD IDARSDLWAV GIILHELVTG
AHPLDPFSAA RLVEIVNLEL PMPAAGERRP DVGPLGALID RCLKKRAAER IGSAKELLAE
LEDLLPGRTS LALSEDESPF AGLAAFQEAD APRFFGRERE VAALLTRLRN QQLVAVAGAS
GAGKSSFVRA GVIPALKRLG DRWEAFILRP GHRPLSALVD VLAQVAEAEP AGATGSPELP
NHDELVATLR AQPGSLGARL RARCRRVGKR HRILLFVDQF EELYTLGAAA EARAAFVACL
AGAADDASSP LRVLLAIRSD FLDRIADDHH FMTEVTRGLS FLPSMGRDGL REALTRPTDA
AGHRFETPAM VEHMLSTLES TRSPLPLLQF TAAKLWEARD RERRILTRES YERLGGVAGA
LSAHADAVLS ALPPHEQRLA RAVLLRLVTP ERTRAVVRLE ELRELARDGQ GDADQAIAQV
VQHLAAARLL LIETGGEREG TTVELVHESL IERWAKLGQW LAESEQDAEF LARLRAAAEP
WDASGQAEGL LWRDRAANDA RAWYERRRAE HGAEWRAGLG RREERYLLAV VAHCERARRL
RRRLTTGVIA ALTAFAVAVS YLAVRADQQA ARADREALRA RNATRVAAAR ELHADPTSVL
AILREVEPHD EPRGWAVLAR WALYSGLSRA VLVHPDGVLD ADYSPDGRRI VTASADRAAR
VWSADGTGEP IVLRGHTAQV DSAAFSPDGR RVVTGAQDRT ARVWNADGAG EPIVLRGHTA
QVDSAAFSPD GRRVVTGAQD RTARVWNADG AGEPIVLRGH TAQVDSAAFS PDGRRVVTGA
QDRTARVWNA DGAGEPIVLR GHDDRVYAAA FSPDAARIVT ASADRTARVW RADGAGEPIV
LRGHTDQVYS AAFSSDGERI VTGSQDRTAR VWRADGAGEP IVLRGHDDRV YAAAFSPDGE
RIVTASWDRT VRVWNADGTG EPIVLRGHTD RIYGVAFSPD GRRVATASQD ETARVWSADG
TGEPIVLRGH ADRVYAAAFS PDAARIVTAS ADRTARVWRA DGAGEPIVLR GHADRVYAAA
FSPDGRRVAT ASQDETARVW NADGTGDPFV LRGHDDQVYS VAFSPDGHHL VTASHDRTAR
VWNADDTGEP LVLRGHTDRV YGAAFSPDGR RVASASLDRT VRVWNADGTG EPIVLRGHDD
EVNSVAFSPD GQHIVSGSAD KTVRVWRADG DGEPIVLRGH TDQVYAAVFS PDGQRIASGS
WDRTVRVWRA DGAGEPLVLR GHTDRVYAAA FSPDGQRIVS GSSDNTARVW RADGAGEPTV
LLGHDDGINA VAFSPDGRRV ATASWDRTAR VWRADGAGEP HVLRGHEHWV LGVAFSPDGT
RIATGSQDET VRVWHGGGAG EPLVLRADSP INAVAFSPDG QRIVAAADDR VVRVWTDLEE
LRSVDDPKLW AATTYCMPVD RRMELLRVPE AAARASREAC VRHVEAARAA AGRPW
//
