ID S4Y3N0_SORCE Unreviewed; 529 AA.
AC S4Y3N0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Glucosylceramidase {ECO:0008006|Google:ProtNLM};
GN ORFNames=SCE1572_39610 {ECO:0000313|EMBL:AGP40077.1};
OS Sorangium cellulosum So0157-2.
OC Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae; Sorangium.
OX NCBI_TaxID=1254432 {ECO:0000313|EMBL:AGP40077.1, ECO:0000313|Proteomes:UP000014803};
RN [1] {ECO:0000313|EMBL:AGP40077.1, ECO:0000313|Proteomes:UP000014803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=So0157-2 {ECO:0000313|EMBL:AGP40077.1,
RC ECO:0000313|Proteomes:UP000014803};
RX PubMed=23812535; DOI=10.1038/srep02101;
RA Han K., Li Z.F., Peng R., Zhu L.P., Zhou T., Wang L.G., Li S.G.,
RA Zhang X.B., Hu W., Wu Z.H., Qin N., Li Y.Z.;
RT "Extraordinary expansion of a Sorangium cellulosum genome from an alkaline
RT milieu.";
RL Sci. Rep. 3:2101-2101(2013).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 30 family.
CC {ECO:0000256|ARBA:ARBA00005382, ECO:0000256|RuleBase:RU361188}.
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DR EMBL; CP003969; AGP40077.1; -; Genomic_DNA.
DR AlphaFoldDB; S4Y3N0; -.
DR STRING; 1254432.SCE1572_39610; -.
DR KEGG; scu:SCE1572_39610; -.
DR PATRIC; fig|1254432.3.peg.8961; -.
DR eggNOG; COG5520; Bacteria.
DR HOGENOM; CLU_014379_4_0_7; -.
DR Proteomes; UP000014803; Chromosome.
DR GO; GO:0004348; F:glucosylceramidase activity; IEA:InterPro.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR033452; GH30_C.
DR InterPro; IPR001139; Glyco_hydro_30.
DR InterPro; IPR033453; Glyco_hydro_30_TIM-barrel.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR11069; GLUCOSYLCERAMIDASE; 1.
DR PANTHER; PTHR11069:SF23; LYSOSOMAL ACID GLUCOSYLCERAMIDASE; 1.
DR Pfam; PF02055; Glyco_hydro_30; 1.
DR Pfam; PF17189; Glyco_hydro_30C; 1.
DR PRINTS; PR00843; GLHYDRLASE30.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|RuleBase:RU361188};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361188};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 123..466
FT /note="Glycosyl hydrolase family 30 TIM-barrel"
FT /evidence="ECO:0000259|Pfam:PF02055"
FT DOMAIN 470..526
FT /note="Glycosyl hydrolase family 30 beta sandwich"
FT /evidence="ECO:0000259|Pfam:PF17189"
FT REGION 13..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 529 AA; 55536 MW; 7B75191C6B3F18D5 CRC64;
MLAFFFMACG PSTSATEPEG SGGSGSGAGG PGSVAGSSTS TGGSTGSGGT DASASTGSGG
AGGEPPGDGG AGGSSTGGGP PVVEPTLITS GPNDYWKTGT PTEVTSGNAD VTVDEATTHQ
RWDGFGGTFN EVGWNVLSML GEAERARAIE LLFDKHEGAA FAYGRIPIGA SDYAMDRYTL
DETPNDTAMA SFSIDRDKER LIPYIKAALV VRPGLHLWAS PWTPPTWMKS NGAFDGGRMK
DDASTLQAYA LYLAKFVEAY AGEGITIEAV HPQNEPNYET RYPSCTWTGA LMAKFIGTYL
GPTFADRGLT AQIYLGTMSN NESGKDGAII SAVTGDATAM GYVKGFGLQW NMMSSASGLR
SRNLPIVQTE HKCGNYPWNP TGSPPFDAQK APNDHAYAEE SWGLIRDWIK AGVTSYSAWN
MVLDTAGKNL DSERPWPQNA LLTVDTAAKT LNVTPVYHVF RHVSEYVDPG ATRVATTGGD
ALAFKNPDGS IVTILYNSGN AAKMTVLDVA GKKLQFSVPA HGWATVNWT
//
