ID S4YXS9_SERPL Unreviewed; 510 AA.
AC S4YXS9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Alkaline phosphatase {ECO:0000313|EMBL:AGP47373.1};
GN ORFNames=M621_22315 {ECO:0000313|EMBL:AGP47373.1};
OS Serratia plymuthica S13.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Serratia.
OX NCBI_TaxID=1348660 {ECO:0000313|EMBL:AGP47373.1, ECO:0000313|Proteomes:UP000014900};
RN [1] {ECO:0000313|EMBL:AGP47373.1, ECO:0000313|Proteomes:UP000014900}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S13 {ECO:0000313|EMBL:AGP47373.1};
RX PubMed=23929484;
RA Muller H., Furnkranz M., Grube M., Berg G.;
RT "Genome Sequence of Serratia plymuthica Strain S13, an Endophyte with
RT Germination- and Plant-Growth-Promoting Activity from the Flower of Styrian
RT Oil Pumpkin.";
RL Genome Announc. 1:e00594-13(2013).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|PIRSR:PIRSR601952-2};
CC Note=Binds 1 Mg(2+) ion. {ECO:0000256|PIRSR:PIRSR601952-2};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR601952-2};
CC Note=Binds 2 Zn(2+) ions. {ECO:0000256|PIRSR:PIRSR601952-2};
CC -!- SIMILARITY: Belongs to the alkaline phosphatase family.
CC {ECO:0000256|RuleBase:RU003946}.
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DR EMBL; CP006566; AGP47373.1; -; Genomic_DNA.
DR RefSeq; WP_006328183.1; NC_021659.1.
DR AlphaFoldDB; S4YXS9; -.
DR KEGG; sry:M621_22315; -.
DR PATRIC; fig|1348660.3.peg.4369; -.
DR eggNOG; COG1785; Bacteria.
DR HOGENOM; CLU_008539_4_1_6; -.
DR Proteomes; UP000014900; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016791; F:phosphatase activity; IEA:InterPro.
DR CDD; cd16012; ALP; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR001952; Alkaline_phosphatase.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR PANTHER; PTHR11596; ALKALINE PHOSPHATASE; 1.
DR PANTHER; PTHR11596:SF5; ALKALINE PHOSPHATASE; 1.
DR Pfam; PF00245; Alk_phosphatase; 1.
DR PRINTS; PR00113; ALKPHPHTASE.
DR SMART; SM00098; alkPPc; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|PIRSR:PIRSR601952-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601952-2};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|PIRSR:PIRSR601952-2}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..510
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004526583"
FT ACT_SITE 119
FT /note="Phosphoserine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-1"
FT BINDING 69
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 69
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 180
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 182
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 340
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 345
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 349
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 386
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 387
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 467
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
SQ SEQUENCE 510 AA; 54988 MW; 68EFF448BE48F612 CRC64;
MFRSTLATHL ALSVTLCTGW VATVCAEEKA QLVQREDPYF KQAQEQLQQR LAQPKNTHRA
KNVILVVGDG MGFSTVTAAR IFEGQQRGVD GESNVLAWEA FPYLAAAKTY SANAQITDSA
PSAVAMTTGV KTLNDLMGLD HTASLNNCED QKTKTVTTLW EMAASLGMST GAVTTATITH
ATPGATYAHI ANRDWESDAK MPAEALAAGC SDIARQLVEM KYGNGLNVAM GGGRANFLPE
SATDPEYAAK KGNRKDGRDL TQAWLKRYGE RGSYVWNQSQ FDRIDPAKVD HLLALFEPSH
MNFDHDRRED AAGEPSLAEM TGKAIDILAR NPEGYLLLVE GGRIDHGSHN GNAYRTLTDT
VALNEAVKTI IGKVDLNETL VVVTGDHSHT LTLAGYAKRG NPILGISIGV NGKPLLGSDG
KPYTTVSFAN GPGGVIPLPE RPALTMEQAS APDFIQPALV PMKSETHGGE DLGIYAIGPW
SHLFQGTVEE NYTFHVMNYA SRIGERLSNL
//
