ID   S5G514_9SALA            Unreviewed;       339 AA.
AC   S5G514;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
DE   Flags: Fragment;
GN   Name=LIG-4 {ECO:0000313|EMBL:AGQ56300.1};
OS   Cynops orientalis (oriental fire-bellied newt).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Salamandridae; Pleurodelinae; Cynops.
OX   NCBI_TaxID=137245 {ECO:0000313|EMBL:AGQ56300.1};
RN   [1] {ECO:0000313|EMBL:AGQ56300.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23827877; DOI=10.1093/molbev/mst122;
RA   Shen X.X., Liang D., Feng Y.J., Chen M.Y., Zhang P.;
RT   "A versatile and highly efficient toolkit including 102 nuclear markers for
RT   vertebrate phylogenomics, tested by resolving the higher level
RT   relationships of the caudata.";
RL   Mol. Biol. Evol. 30:2235-2248(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC         (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC         diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003,
CC         ECO:0000256|RuleBase:RU000617};
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|ARBA:ARBA00007572, ECO:0000256|RuleBase:RU004196}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KC165421; AGQ56300.1; -; Genomic_DNA.
DR   AlphaFoldDB; S5G514; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd07903; Adenylation_DNA_ligase_IV; 1.
DR   Gene3D; 1.10.3260.10; DNA ligase, ATP-dependent, N-terminal domain; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   InterPro; IPR044125; Adenylation_DNA_ligase_IV.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   NCBIfam; TIGR00574; dnl1; 1.
DR   PANTHER; PTHR45997; DNA LIGASE 4; 1.
DR   PANTHER; PTHR45997:SF1; DNA LIGASE 4; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SUPFAM; SSF117018; ATP-dependent DNA ligase DNA-binding domain; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000617};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU000617}; Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT   DOMAIN          262..339
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AGQ56300.1"
FT   NON_TER         339
FT                   /evidence="ECO:0000313|EMBL:AGQ56300.1"
SQ   SEQUENCE   339 AA;  38557 MW;  2C61261F8DFA1455 CRC64;
     IEVLGLPKEG KDASKLLNYR APSGSHGDAG DFAMIAYFVL KPRFPTHGTL TIQEVNGLLD
     AIANNNAAKK KDNVKKSLLQ LITRSSALEQ KWLIRMIIKD MKLGFSQQTV FSIFHPDATE
     LHNVTTDLEK VCLQLHDPTV FLSDVSIMLF SAFKPMLAAI ANIKNIEKQM NNQSFYIETK
     LDGERMQMHK DGDVYKYFSR NGFDYTQQFG ASPLDGSLTP FIHNVFRIDV QNCILDGEMM
     AYNPETQTFM QKGSKFDIKR LMDDSELHTC YCVFDILMLN DQKLARESLR KRCEILHKVF
     TPIIGRLHLV HKTEASTKKN VVDALNEAID NREEGIMVK
//