ID S5PG64_PANTR Unreviewed; 786 AA.
AC S5PG64;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Toll-like receptor 1 {ECO:0000256|PIRNR:PIRNR037595};
GN Name=TLR1 {ECO:0000313|EMBL:AGR82347.1};
OS Pan troglodytes ellioti.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=756884 {ECO:0000313|EMBL:AGR82347.1};
RN [1] {ECO:0000313|EMBL:AGR82347.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B03 {ECO:0000313|EMBL:AGR82347.1};
RX PubMed=23851028; DOI=10.1093/hmg/ddt335;
RA Quach H., Wilson D., Laval G., Patin E., Manry J., Guibert J.,
RA Barreiro L.B., Nerrienet E., Verschoor E., Gessain A., Przeworski M.,
RA Quintana-Murci L.;
RT "Different selective pressures shape the evolution of Toll-like receptors
RT in human and African great ape populations.";
RL Hum. Mol. Genet. 22:4829-4840(2013).
CC -!- FUNCTION: Participates in the innate immune response to microbial
CC agents. Specifically recognizes diacylated and triacylated
CC lipopeptides. Cooperates with TLR2 to mediate the innate immune
CC response to bacterial lipoproteins or lipopeptides.
CC {ECO:0000256|PIRNR:PIRNR037595}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU363040}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU363040}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595,
CC ECO:0000256|RuleBase:RU363040}.
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DR EMBL; KF319539; AGR82347.1; -; Genomic_DNA.
DR AlphaFoldDB; S5PG64; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF261; TOLL-LIKE RECEPTOR 1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01463; LRRCT; 1.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00364; LRR_BAC; 3.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|RuleBase:RU363040};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU363040};
KW Transmembrane {ECO:0000256|RuleBase:RU363040};
KW Transmembrane helix {ECO:0000256|RuleBase:RU363040}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|RuleBase:RU363040"
FT CHAIN 25..786
FT /note="Toll-like receptor 1"
FT /evidence="ECO:0000256|RuleBase:RU363040"
FT /id="PRO_5011018733"
FT TRANSMEM 579..604
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363040"
FT DOMAIN 635..776
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 786 AA; 90315 MW; AFDD8A7B7E424AFA CRC64;
MPSIFHFAII FMLILQIRIQ LSEESEFLVD RSKNGLIHVP KDLSQKTTIL NISQNYISEL
WTSDILSLSK LRILIISHNR IQYLDISVFK FNHELEYLDL SHNKLVKISC HPAVNLKHLD
LSFNAFDALP ICKEFGNMSQ LKFLGLSTTH LEKSSVLPIA HLNISKILLV LGETYGEKED
PEGLQDFNTE SLHIVFPTNK EFHFILDVSV KTVANLELSN IKCVLEDNKC SYFLSILAKL
QTNPKLSSLT LNNIETTWNS FIRILQLVWH TTVWYFSISN VKLQGQLDFR DFDYSGTSLK
ALSIHQVVSD VFSFPQSDIY EIFSNMNIKN FTVSGTRMVH MLCPSKISPF LHLDFSNNLL
TDTVFENCGH LTELETLILQ MNQLKELSKI AEMTTQMKSL QQLDISQNSV SYDEKKGDCS
WTKSLLSLNM SSNILTDTIF RCLPPRIKVL DLHSNKIKSV PKQVVKLEAL QELNVAFNSL
TDLPGCGSFS SLSVLIIDHN SVSHPSADFF QSCQKMRSIK AGDNPFQCTC ELREFVKNID
QVSSEVLEGW PDSYKCDYPE SYRGSPLKDF HMSELSCNIT LLIVTIVATM LVLAVTVTSL
CIYLDLPWYL RMVCQWTQTR RRARNIPLEE LQRNLQFHAF ISYSGHDSFW VKNELLPNLE
KEGMQICLHE RNFVPGKSIV ENIITCIEKS YKSIFVLSPN FVQSEWCHYE LYFAHHNLFH
EGSNNLILIL LEPIPQYSIP SSYHKLKSLM ARRTYLEWPK EKSKRGLFWA NLKAAINIKL
TEQAKK
//
