ID S5RJY6_9STRE Unreviewed; 693 AA.
AC S5RJY6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Penicillin-binding protein 2B {ECO:0000313|EMBL:AGS05113.1};
GN ORFNames=KE3_0605 {ECO:0000313|EMBL:AGS05113.1};
OS Streptococcus lutetiensis 033.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1076934 {ECO:0000313|EMBL:AGS05113.1, ECO:0000313|Proteomes:UP000015268};
RN [1] {ECO:0000313|EMBL:AGS05113.1, ECO:0000313|Proteomes:UP000015268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=033 {ECO:0000313|EMBL:AGS05113.1,
RC ECO:0000313|Proteomes:UP000015268};
RX PubMed=23782707; DOI=10.1186/1471-2180-13-141;
RA Jin D., Chen C., Li L., Lu S., Li Z., Zhou Z., Jing H., Xu Y., Du P.,
RA Wang H., Xiong Y., Zheng H., Bai X., Sun H., Wang L., Ye C., Gottschalk M.,
RA Xu J.;
RT "Dynamics of fecal microbial communities in children with diarrhea of
RT unknown etiology and genomic analysis of associated Streptococcus
RT lutetiensis.";
RL BMC Microbiol. 13:141-141(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; CP003025; AGS05113.1; -; Genomic_DNA.
DR RefSeq; WP_020916412.1; NC_021900.1.
DR AlphaFoldDB; S5RJY6; -.
DR GeneID; 58527888; -.
DR KEGG; slu:KE3_0605; -.
DR PATRIC; fig|1076934.5.peg.546; -.
DR HOGENOM; CLU_009289_7_0_9; -.
DR Proteomes; UP000015268; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0071972; F:peptidoglycan L,D-transpeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR Gene3D; 1.10.10.1230; Penicillin-binding protein, N-terminal non-catalytic domain, head sub-domain; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR047982; PBP2B.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; NF038278; strep_PBP2B; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 67..305
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 354..683
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 693 AA; 74777 MW; F857011B0209515E CRC64;
MSVKKRLSKI NIAKKTTSIT KRIYLIFAVI VVLFSIIILR LAQMQILNKS FYDDKLNSST
TYKVTSSSPR GQIFDAAGNL LVSNNVKQVV AFTRSNTITA EEMKNLARTL STLVDFTETN
VTTRQKKDYY LADSDTYAKV VKSLPNNQKY DNYGNNLTES KVYANAVKAV TDDEINYSED
ELKLVYIFSQ MNAASTFSTV NLTTGDLTDD QIAYITANRS KLSGISIATD WDRQTSTGSL
STLIGTVSSK QSGLPAEEAE EYLAKGYSMN DRVGTSYLEK AYEDDLQGTH TVREITTDKN
GNVVSDDVTR EGKAGKNLKL TVNSDFQLGV ENILNQYYGA SIAAGFATYS EGAYAVALNP
KTGAILAMAG LSHETGSSTT TLDALGTIND LFVPGSVVKA ATISSGWENN AISGNQVIAD
QSINLAGSPA IKSWFTGSGA TNITAVQALE YSSNTYMVQV ALKMMGQEYY SGMALATTGT
KEAMEELRAT YAEYGLGTST GMDLPETTTG YLSEDYSPGN VLTEAFGQYD SYTPMQLAQY
AATVANGGNR VAPHIVDSVY DNDGTTGLGN LSKMIDTNVL NKVNISSDEM AILQQGFYQV
VNSTSGYATG THMRGNVTIA GKTGTAETYA IDANGNAVTT VNLSVLAYDY SKNNDSKIAV
AVIIPHLTSD ENHPNQLIAR DIINLYMSTY ANK
//
