ID   S5RLL5_9REOV            Unreviewed;       176 AA.
AC   S5RLL5;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=NSP4 {ECO:0000313|EMBL:AGS13894.1};
DE   Flags: Fragment;
OS   Rotavirus A.
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Sedoreoviridae; Rotavirus.
OX   NCBI_TaxID=28875 {ECO:0000313|EMBL:AGS13894.1};
RN   [1] {ECO:0000313|EMBL:AGS13894.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=RVA/Human-wt/PAK/2/2010/G1P6 {ECO:0000313|EMBL:AGS13894.1};
RA   Tamim S., Matthijnssens J., Heylen E., Zeller M., Ranst M.V.;
RT   "Unexpected animal derived NSP4 and VP6 gene segments present in human
RT   rotaviruses from Pakistan.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KC847022; AGS13894.1; -; Genomic_RNA.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.430; -; 1.
DR   HAMAP; MF_04091; ROTA_NSP4; 1.
DR   InterPro; IPR002107; Rotavirus_NSP4.
DR   Pfam; PF01452; Rota_NSP4; 1.
DR   SUPFAM; SSF58030; Rotavirus nonstructural proteins; 1.
PE   3: Inferred from homology;
KW   Activation of host autophagy by virus {ECO:0000256|ARBA:ARBA00023050};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Enterotoxin {ECO:0000256|ARBA:ARBA00022861};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00023050};
KW   Membrane {ECO:0000256|SAM:Phobius}; Toxin {ECO:0000256|ARBA:ARBA00022656};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        30..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   COILED          86..113
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AGS13894.1"
FT   NON_TER         176
FT                   /evidence="ECO:0000313|EMBL:AGS13894.1"
SQ   SEQUENCE   176 AA;  20481 MW;  7E43601499E3F8AA CRC64;
     KMEKLTDLNY TLSVITLMNS TLHTILEDPG MAYFPYIASV LTVLFTLHKA SIPTMKIALK
     TSKCSYKVVK YCIVTIFNTL LKLAGYKEQI TTKDEMEKQM DRVVKEMRRQ LEMIDKLTTR
     EIEQVELLKR IYDKLMVQSI GEIDMTKEIN QKNVKTLEEW ESGRNPYEPK EVTAAM
//