ID   S5S0W4_9REOV            Unreviewed;       175 AA.
AC   S5S0W4;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=NSP4 {ECO:0000313|EMBL:AGS13905.1};
DE   Flags: Fragment;
OS   Rotavirus A.
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Sedoreoviridae; Rotavirus.
OX   NCBI_TaxID=28875 {ECO:0000313|EMBL:AGS13905.1};
RN   [1] {ECO:0000313|EMBL:AGS13905.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=RVA/Human-wt/PAK/30/2010/G2P4 {ECO:0000313|EMBL:AGS13905.1};
RA   Tamim S., Matthijnssens J., Heylen E., Zeller M., Ranst M.V.;
RT   "Unexpected animal derived NSP4 and VP6 gene segments present in human
RT   rotaviruses from Pakistan.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KC847033; AGS13905.1; -; Genomic_RNA.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.430; -; 1.
DR   HAMAP; MF_04091; ROTA_NSP4; 1.
DR   InterPro; IPR002107; Rotavirus_NSP4.
DR   Pfam; PF01452; Rota_NSP4; 1.
DR   SUPFAM; SSF58030; Rotavirus nonstructural proteins; 1.
PE   3: Inferred from homology;
KW   Activation of host autophagy by virus {ECO:0000256|ARBA:ARBA00023050};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Enterotoxin {ECO:0000256|ARBA:ARBA00022861};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00023050};
KW   Membrane {ECO:0000256|SAM:Phobius}; Toxin {ECO:0000256|ARBA:ARBA00022656};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        31..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   COILED          85..112
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AGS13905.1"
FT   NON_TER         175
FT                   /evidence="ECO:0000313|EMBL:AGS13905.1"
SQ   SEQUENCE   175 AA;  20335 MW;  427286E53823F3E7 CRC64;
     MEKLTDLNYT LSVITLMNST LHTILEDPGM AYFPYIASVL TVLFTLHKAS IPTMKIALKT
     SKCSYKVVKY CIVTIFNTLL KLAGYKEQIT TKDEIEKQMD RVVKEMRRQL EMIDKLTTRE
     IEQVELLKRI YDKLMVQSIG EIDMTKEINQ KNVKTLEEWE SGRNPYEPKE VTAAM
//