ID S5ZEH5_HBV Unreviewed; 817 AA.
AC S5ZEH5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AGT38678.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AGT38678.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AGT38678.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EP0186 {ECO:0000313|EMBL:AGT38678.1};
RX PubMed=23936156;
RA Huang C.J., Wu C.F., Lan C.Y., Sung F.Y., Lin C.L., Liu C.J., Liu H.F.,
RA Yu M.W.;
RT "Impact of genetic heterogeneity in polymerase of hepatitis B virus on
RT dynamics of viral load and hepatitis B progression.";
RL PLoS ONE 8:E70169-E70169(2013).
RN [2] {ECO:0000313|EMBL:AGT38678.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EP0186 {ECO:0000313|EMBL:AGT38678.1};
RA Huang C.-J., Wu C.-F., Lan C.-Y., Sung F.-Y., Lin C.-L., Liu C.-J.,
RA Liu H.-F., Yu M.-W.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; KC792833; AGT38678.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR HAMAP; MF_04073; HBV_DPOL; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR037531; HBV_DPOL.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022632};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT DOMAIN 331..574
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGT38678.1"
SQ SEQUENCE 817 AA; 91466 MW; 330A6DE9DD0C02BA CRC64;
LLDDEAGPLE EELPRLADEG LNRRVAEDLN LGNPNVSIPW THKVGNFTGL YSSTVPVFNP
EWQTPSFPXI HLQEDIINRC QQYVGPLTVN EKRRLKLIMP ARFYPNLTKY LPLDKGIKPY
YPEHVVNHYF KTRHYLHTLW KAGILYKRET TRSASFCGSP YSWEQELQHG RLVFQTSTRH
GDESFCSQSS GILSRSPVGP CIRSQLKQSR LGLQSQQGSL ARGXSGRSGS IRARVHXTTR
RSFGVEPSGS GHIDNSASST SSCLHQSAVR KTAHSHLSTS KRQSSSGHAV ELHNIPCWWL
QFRNSKPCSD YCLTHIVNLL EDWGPCTEHG EHXIRIPRTP ARVTGGVFLV DKNPHNTTES
RLVVDFSQFS RGNTQVSWPK FAVPNLQSLT NLLSSNLCWL SLDVSAAFYH IPLHPAAMPH
LLVGSSGLXR YVARLSSTSR NINHQHGAMQ DLHDSCSRNL YVSLLLLYKT FGRKLHLYSH
PIILGFRKIP MGVGLSPFLL AQFTSAICSV VRRAFPHCLA FSYMDDVVLG AKSVQHLESL
FTAITNFLLS LGIHLNPNKT KRWGYSLNFM GYVIGSWGTL PQEHIVLKIK QCFRKLPVNR
PIDWKVCQRI VGLLGFAAPF TQCGYPALMP LYACIQSKQA FTFSPTYKAF LCKQYLNLYP
VARQRSGLCQ VFADATPTGW GLAIGHRRXR GTFVAPLPIH TAELLAACFA RSRSGAKLIG
TDNSVVLSRK YTSFPWLLGC AANWILRGTS FVYVPSALNP ADDPSRGRLG IYRPLLHLPF
RPTTGRTSLY AVSPSVPSHL PDRVHFASPL HVAWRPP
//
