ID S5ZEZ1_HBV Unreviewed; 809 AA.
AC S5ZEZ1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AGT38753.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AGT38753.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AGT38753.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EP0262 {ECO:0000313|EMBL:AGT38753.1};
RX PubMed=23936156;
RA Huang C.J., Wu C.F., Lan C.Y., Sung F.Y., Lin C.L., Liu C.J., Liu H.F.,
RA Yu M.W.;
RT "Impact of genetic heterogeneity in polymerase of hepatitis B virus on
RT dynamics of viral load and hepatitis B progression.";
RL PLoS ONE 8:E70169-E70169(2013).
RN [2] {ECO:0000313|EMBL:AGT38753.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EP0262 {ECO:0000313|EMBL:AGT38753.1};
RA Huang C.-J., Wu C.-F., Lan C.-Y., Sung F.-Y., Lin C.-L., Liu C.-J.,
RA Liu H.-F., Yu M.-W.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; KC792909; AGT38753.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR HAMAP; MF_04073; HBV_DPOL; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR037531; HBV_DPOL.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022632};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT DOMAIN 323..566
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 185..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGT38753.1"
SQ SEQUENCE 809 AA; 90553 MW; 392DC58DED0786C6 CRC64;
RRVAEDLNLG NLNVSIPWTH KVGNFTGLYS STVPCFNPKW QTPSFPDIHL QEDIVDRCKQ
FVGPLTVNEN RRLKLVMPAR FYPNVTKYLP LDKGIKPYYP EHVVNHYFQT RHYLHTLWKA
GILYKRESTR SASFCGSPYS WEQDLQHGRL VFQTSKRHGD KSFCPQSPGI LPRSSVGPCI
QSQLRKSRLG PQPAQGQLAG RQQGGSGSIR ARVHPSPWGT VGVEPSGSGH THNCASSSSS
CLHQSAVRKT AYSLISTSKG HSSSGHAVEL HHFPPNSSRS QSQGPVLSCW WLQFRNSEPC
SEYCLCHIVN LIEDWGPCTE HGEHRIRTPR TPARVTGGVF LVDKNPHNTT ESRLVVDFSQ
FSRGNTRVSW PKFAVPNLQS LTNLLSSNLS WLSLDVSAAF YHLPLHPAAM PHLLVGSSGL
SRYVARLSSN SRIINNQHRT MQNLHNSCSR NLYVSLMLLY KTYGRKLHLY SHPIILGFRK
IPMGVGLSPF LLAQFTSAIC SVVRRAFPHC LAFSYMDDVV LGAKSVQHLE SLYAAVTNFL
LSLGIHLNPH KTKRWGYSLN FMGYVIGCWG TLPQEHIVQK IKMCFRKLPV NRPIDWKVCQ
RIVGLLGFAA PFTQCGYPAL MPLYACIQTK QAFTFSPTYK AFLSKQYLNL YPVARQRPGL
CQVFADATPT GWGLAIGHQR MRGSFVSPLP IHTAELLAAC FARSRSGARL IGTDNSVVLS
RKYTSFPWLL GCAANWILRG TSFVYVPSAL NPADDPSRGR LGLYRPLLRL VYRPTTGRTS
LYADSPSVPS HLPDRVHFAS PLHVAWRPP
//
