ID S5ZFI0_HBV Unreviewed; 826 AA.
AC S5ZFI0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AGT38938.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AGT38938.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AGT38938.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EP0447 {ECO:0000313|EMBL:AGT38938.1};
RX PubMed=23936156;
RA Huang C.J., Wu C.F., Lan C.Y., Sung F.Y., Lin C.L., Liu C.J., Liu H.F.,
RA Yu M.W.;
RT "Impact of genetic heterogeneity in polymerase of hepatitis B virus on
RT dynamics of viral load and hepatitis B progression.";
RL PLoS ONE 8:E70169-E70169(2013).
RN [2] {ECO:0000313|EMBL:AGT38938.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EP0447 {ECO:0000313|EMBL:AGT38938.1};
RA Huang C.-J., Wu C.-F., Lan C.-Y., Sung F.-Y., Lin C.-L., Liu C.-J.,
RA Liu H.-F., Yu M.-W.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; KC793094; AGT38938.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR HAMAP; MF_04073; HBV_DPOL; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR037531; HBV_DPOL.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022632};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT DOMAIN 340..583
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 199..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT UNSURE 382
FT /note="D or N"
FT /evidence="ECO:0000313|EMBL:AGT38938.1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGT38938.1"
SQ SEQUENCE 826 AA; 92261 MW; 39B0CE1DF0C42EB4 CRC64;
AGPLEEELPR LADEGLNRRV AEDLNLGNPD VSIPWTHKVG NFTGLYSSTV PCFNPXWQTP
SFPDIHLQED IVDRCKQFVG PLTVNEXRRL KLIMPARFYP KVTKYLPLDK GIKPYYPEYV
VNHYFQTRHY LHTLWKAGIL YKRESTRSAS FCGSPYSWEQ DLRHGRLVFQ TSKRHGDKSF
CPQSPGILPR SSVGPCIQSQ LRKSRLGPQP AQGQLAGRQQ GGSGSIRARV HPSPWGTVGV
EPSGSGPTHN CASSSSSCLH QSAVRKAAYS LISTSKGHSS SGHAVELHHF PPNSSRSQSQ
SPVLSCWWLQ FRNSEPCSEY CLCHIVNLIE DWGPCTEHGE HRIRTPRTPA RVTGGVFLVD
KNPHNTTESR LVVDFSQFSR GDTRVSWPKF AVPNLQSLTN LLSSNLSWLS LDVSAAFYHL
PLHPAAMPHL LVGSSGLSRY VARLSSNSRI INDQHRTMQN LHDSCSRNLY VSLMLLYKTY
GRKLHLYSHP IILGFRKIPM GVGLSPFLLA QFTSAICSVV RRAFPHCLAF SYMDDVVLGA
KSVQHLESIY ASVTNFLLSL GIHLNPHKTK RWGYSLNFMG YVIGSWGTLP QEHIVQKIKM
CFRKLPVNRP IDWKVCQRXV GLLGFAAPFT QCGYPALMPL YACIQAKQAF TFSPTYKAFL
SKQYLTLYPV ARQRPGLCQV FADATPTGWG LAXGHQRMRG TFGSPLPIHT AELLAACFAR
SRSGAKLIGT DNSVVLSRKY TSFPWLLGCA AXWILRGTSF VYVPSALNPA DDPSRGRLGL
YRPLLRLLFR PTTGRTSLYA DSPSVPSHLP DRVHFASPLH VAWRPP
//
