ID   S5ZK32_HBV              Unreviewed;       831 AA.
AC   S5ZK32;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:AGT38571.1};
OS   Hepatitis B virus (HBV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=10407 {ECO:0000313|EMBL:AGT38571.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:AGT38571.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=EP0079 {ECO:0000313|EMBL:AGT38571.1};
RX   PubMed=23936156;
RA   Huang C.J., Wu C.F., Lan C.Y., Sung F.Y., Lin C.L., Liu C.J., Liu H.F.,
RA   Yu M.W.;
RT   "Impact of genetic heterogeneity in polymerase of hepatitis B virus on
RT   dynamics of viral load and hepatitis B progression.";
RL   PLoS ONE 8:E70169-E70169(2013).
RN   [2] {ECO:0000313|EMBL:AGT38571.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=EP0079 {ECO:0000313|EMBL:AGT38571.1};
RA   Huang C.-J., Wu C.-F., Lan C.-Y., Sung F.-Y., Lin C.-L., Liu C.-J.,
RA   Liu H.-F., Yu M.-W.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000077};
CC   -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC       {ECO:0000256|ARBA:ARBA00007994}.
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DR   EMBL; KC792726; AGT38571.1; -; Genomic_DNA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   HAMAP; MF_04073; HBV_DPOL; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001462; DNApol_viral_C.
DR   InterPro; IPR000201; DNApol_viral_N.
DR   InterPro; IPR037531; HBV_DPOL.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00336; DNA_pol_viral_C; 1.
DR   Pfam; PF00242; DNA_pol_viral_N; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022632};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Inhibition of host innate immune response by virus
KW   {ECO:0000256|ARBA:ARBA00022632};
KW   Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT   DOMAIN          345..588
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          181..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        207..226
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AGT38571.1"
SQ   SEQUENCE   831 AA;  92835 MW;  637EF03C6A51F7A5 CRC64;
     LLDKEAGPLE EELPRLADEG LNRRVAEDLN LGDLNVSIPW THKVGNFTGL YSSTVPCFNP
     NWQTPSFPDI HLKEDIVDRC KQFVGPLTVN ENRRLKLIMP ARFYPKVTKY LPLDKGIKPY
     YPEYVVNHYF QTRHYLHTLW XAGILYKRES TRSASFCGSP YSWEQDLQHG RLVFQTSKRH
     GDKSFCPQSP GILPRSPVGP CIQSQLRKSR LGPQPAQGQL AGRQQGGSGS IRARVHPSPW
     GTVGVEPSGS GPTYNCASSS SSCLHQSAVR KAAYSLISTS KGHSSSGHAV ELHHXPPNSS
     RSQSQGPVLS CWWLQFRNSE PCSEYCLXHI VNLIEDWGPC TEHGEHRIRT PRTPARVTGG
     VFLVDKNPHN TTESRLVVDF SQFSRGDTRV SWPKFAVPNL QSLTNLLSSN LSWLSLDVSA
     AFYHLPLHPA AMPHLLVGSS GLSRYVARLS SNSRIINDQH RTMQNLHNSC SRNLYVSLML
     LYKTYGRKLH LYSHPIILGF RKIPMGVGLS PFLLAQFTSA ICSVVRRAFP HCLAFSYMDD
     VVLGAKSVXH LESLYAAVTX FLLSLGIHLN PHKTKRWGYS LNFMGYVIGS WGTLPQEHIV
     QKIKLCFRKL PVNRPIDWKV CQRIVGLLGF AAPFTQCGYP ALMPLYACIQ AKQAFTFSPT
     YKAFLRQQYL NLYPVARQRP GLCQVFADAT PTGWGLAXGH QRMRGTFGSP LPIHTAELLA
     ACFARSRSGA KLIGTDNSVV LSRKYTSFPW LLGCAANWIL RGTSFVYVPS ALNPADDPSR
     GRLGLYRPLL RLLYRPTTGR TSLYADSPSV PSHLPDRVHF ASPLHVAWKP P
//