ID S6A6U8_HBV Unreviewed; 832 AA.
AC S6A6U8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AGT38640.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AGT38640.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AGT38640.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EP0148 {ECO:0000313|EMBL:AGT38640.1};
RX PubMed=23936156;
RA Huang C.J., Wu C.F., Lan C.Y., Sung F.Y., Lin C.L., Liu C.J., Liu H.F.,
RA Yu M.W.;
RT "Impact of genetic heterogeneity in polymerase of hepatitis B virus on
RT dynamics of viral load and hepatitis B progression.";
RL PLoS ONE 8:E70169-E70169(2013).
RN [2] {ECO:0000313|EMBL:AGT38640.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EP0148 {ECO:0000313|EMBL:AGT38640.1};
RA Huang C.-J., Wu C.-F., Lan C.-Y., Sung F.-Y., Lin C.-L., Liu C.-J.,
RA Liu H.-F., Yu M.-W.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; KC792795; AGT38640.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR HAMAP; MF_04073; HBV_DPOL; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR037531; HBV_DPOL.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022632};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT DOMAIN 346..589
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 181..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGT38640.1"
SQ SEQUENCE 832 AA; 92945 MW; F625F13E5EEA5BB7 CRC64;
LLLDEEAGPL EEELPRLADE GLNRRVAEDL NLGNLNVSIP WTHKVGNFTG LYSSTVPCFN
PKWQTPSFPD IHLQEDIVDR CKQFVGPLTV NENRRLKLIM PARFYPNVTK YLPLDKGIKP
YYPEYVVNHY FQTRHYLHTL WKAGILYKRE STRSASFCGS PYSWEQDLQH GRLVFQTSKR
HGDKSFCPQS PGILPRSSVG PSIQSQLRKS RLGPQPAQGQ LAGRQQGGSG SIRARVHPSP
WGTVGVEPSG SGPTHNCASS SSSCLHQSAV RKAAYSLIST SKGHSSSGHA VELHHFPPNS
SRSQSQGPVX SCWWLQFRNS EPCSEYCLCH IVNLIEDWGP CTEHGEHRIR TPRTPARVTG
GVFLVDKNPH NTTESRLVVD FSQFSRGNTR VSWPKFAVPN LQSLTNLLSS NLSWLSLDVS
AAFYHLPLHP AAMPHLLVGS SGLSRYVARL SSNSRIINNQ HRTMQNLHNS CSRNLYVSLM
LLYKTYGRKL HLYSHPIILG FRKIPMGVGL SPFLLAQFTS AICSVVRRAF PHCLAFSYMD
DVVLGAKSVQ HLESLYAAVT NFLLSLGIHL NPHKTKRWGY SLNFMGYVIG SWGTLPQEHI
VQKIKMCFRK LPVNRPIDWK VCQRIVGLLG FAAPFTQCGY PALMPLYACI QAKQAFTFSP
TYKAFLSKQY LNLYPVARQR PGLCQVFADA TPTGWGLAIG HQRMRGTFVS PLPIHTAELL
AACFARSRSG AKLIGTDNSV VLSRKYTSFP WLLGCAANWI LRGTSFVYVP SALNPADDPS
RGRLGLYRPL LRLLYRPTTG RTSLYAXSPS VPSHLPDRVH FASPLHVAWK PP
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