ID S6A6V8_HBV Unreviewed; 828 AA.
AC S6A6V8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AGT38690.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AGT38690.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AGT38690.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EP0198 {ECO:0000313|EMBL:AGT38690.1};
RX PubMed=23936156;
RA Huang C.J., Wu C.F., Lan C.Y., Sung F.Y., Lin C.L., Liu C.J., Liu H.F.,
RA Yu M.W.;
RT "Impact of genetic heterogeneity in polymerase of hepatitis B virus on
RT dynamics of viral load and hepatitis B progression.";
RL PLoS ONE 8:E70169-E70169(2013).
RN [2] {ECO:0000313|EMBL:AGT38690.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EP0198 {ECO:0000313|EMBL:AGT38690.1};
RA Huang C.-J., Wu C.-F., Lan C.-Y., Sung F.-Y., Lin C.-L., Liu C.-J.,
RA Liu H.-F., Yu M.-W.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; KC792845; AGT38690.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR HAMAP; MF_04073; HBV_DPOL; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR037531; HBV_DPOL.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022632};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT DOMAIN 342..585
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 175..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGT38690.1"
SQ SEQUENCE 828 AA; 92387 MW; 16843468D58A6617 CRC64;
EGSGPLEEEL PRLADEGLNR RVAEDLNLGN LNVSIPWTHK VGNFTGLYSS TVPCFNPKWQ
TPSFPDIHLQ EDIVDRCKQF VGPLTVNENR RLKLIMPARF YPNVTKYLPL DKGIKPYYPE
HVVNHYFQTR HYLHXLWKAG ILYKRESTRS ASFXGSPYSW EQDLQHGRLV FQTSKRHGDK
SCCPQSPGIL PRSSVGPLIQ SQLRKSRLGP QPAQGPLAGR QQGGSGSIRA RVHPSPWGTV
GVEPSGSGHT HNCASSSSSC LHHSAVRKAA DSLISTSKGH SSSGHAVELH HFPPNSSRSQ
SQGPVXSCWW LQFRNSEPCS EYCLXHIVXL IXDWGPCTEH GEHXIRTPRT PARVTGGVFL
VDKNPHNTTE SRLVVDFSQF SRGDTRVSWP KFAVPNLQSL TNLLSSNLSW LSLDVXAAFY
HLPLHPAAMP HLLVGSSGLS RYVARLSSNS RIINNQHRTM QNLHXSCSRN LYVSLMLLYK
TYGRKLHLYS HPIILGFRKI PMGVGLSPFL LAQFTSAICS VVRRAFPHCL AFSYMDDVVL
GAKSVQHLES LYTAVTNFLV SLGIHVNPHK TKRWGYSLNF MGYVIGGWGT LPQEHIXQKI
KMCFRKLPVN RPIDWKVCQR IVGLLGFAAP FTQCGYPALM PLYACIQAKQ AFTFSPTYKA
FLRQQYLNLY PVARQRSGLC QVFADATPTG WGLAIGHQRM RGTFVSPLPI HTAELLAACF
ARSRSGANLI GTDNSVVLSR KYTSFPWLLG CAANWILRGT SFVYVPSALN PADDPSRGRL
GLYRPLLRLV YRPTTGRTSL YADSPSVPSH LPXRVHFASP LHVAWRPP
//
