ID S6FLS4_9CLOT Unreviewed; 211 AA.
AC S6FLS4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=thiamine diphosphokinase {ECO:0000256|ARBA:ARBA00013245};
DE EC=2.7.6.2 {ECO:0000256|ARBA:ARBA00013245};
GN ORFNames=CCH01_11960 {ECO:0000313|EMBL:SLK17189.1};
OS Clostridium chauvoei JF4335.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1351755 {ECO:0000313|EMBL:SLK17189.1, ECO:0000313|Proteomes:UP000190476};
RN [1] {ECO:0000313|Proteomes:UP000190476}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Falquet L., Falquet L.;
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LT799839; SLK17189.1; -; Genomic_DNA.
DR RefSeq; WP_021875524.1; NZ_LT799839.1.
DR AlphaFoldDB; S6FLS4; -.
DR STRING; 1351755.CCH01_11960; -.
DR GeneID; 66301533; -.
DR OrthoDB; 9804377at2; -.
DR Proteomes; UP000190476; Chromosome i.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0030975; F:thiamine binding; IEA:InterPro.
DR GO; GO:0004788; F:thiamine diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009229; P:thiamine diphosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0006772; P:thiamine metabolic process; IEA:InterPro.
DR CDD; cd07995; TPK; 1.
DR Gene3D; 3.40.50.10240; Thiamin pyrophosphokinase, catalytic domain; 1.
DR InterPro; IPR006282; Thi_PPkinase.
DR InterPro; IPR007373; Thiamin_PyroPKinase_B1-bd.
DR InterPro; IPR036371; TPK_B1-bd_sf.
DR InterPro; IPR007371; TPK_catalytic.
DR InterPro; IPR036759; TPK_catalytic_sf.
DR NCBIfam; TIGR01378; thi_PPkinase; 1.
DR PANTHER; PTHR41299; THIAMINE PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR41299:SF1; THIAMINE PYROPHOSPHOKINASE; 1.
DR Pfam; PF04265; TPK_B1_binding; 1.
DR Pfam; PF04263; TPK_catalytic; 1.
DR SMART; SM00983; TPK_B1_binding; 1.
DR SUPFAM; SSF63999; Thiamin pyrophosphokinase, catalytic domain; 1.
DR SUPFAM; SSF63862; Thiamin pyrophosphokinase, substrate-binding domain; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SLK17189.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000190476};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 139..205
FT /note="Thiamin pyrophosphokinase thiamin-binding"
FT /evidence="ECO:0000259|SMART:SM00983"
SQ SEQUENCE 211 AA; 23165 MW; 8008176333FFF274 CRC64;
MKAIIVSGGK APSKKLLENI IKDGNLIIGA DRGCEVLIQN KIIPDYVLGD FDSASKETIL
KLEQLGVPKT KFKEEKDFTD TTSAFNLAID KGATEIVLLG ATGTRYDHAL GNIGLLLKAL
QLGVKAEIID DNNKIYMINK PEILYGNYGD IISFHAYSDL VSELTIKGAK YELNNYDLAV
GDSLTVSNEF LDKPIEINFK NGTLMVLYTK D
//
