ID S6GK87_9GAMM Unreviewed; 775 AA.
AC S6GK87;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:EPJ49296.1};
GN ORFNames=OFPII_01780 {ECO:0000313|EMBL:EPJ49296.1};
OS Osedax symbiont Rs1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Oceanospirillaceae.
OX NCBI_TaxID=1330036 {ECO:0000313|EMBL:EPJ49296.1, ECO:0000313|Proteomes:UP000014822};
RN [1] {ECO:0000313|EMBL:EPJ49296.1, ECO:0000313|Proteomes:UP000014822}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rs1 {ECO:0000313|Proteomes:UP000014822};
RA Yi H., Goffredi S.;
RT "Comparative genomics of two novel heterotrophic symbionts of deep-sea
RT Osedax worms: functional variation and environmental selection.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPJ49296.1}.
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DR EMBL; ASZJ01000012; EPJ49296.1; -; Genomic_DNA.
DR AlphaFoldDB; S6GK87; -.
DR PATRIC; fig|1330036.3.peg.164; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000014822; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000014822}.
FT DOMAIN 6..189
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 192..293
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 347..397
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 775 AA; 84839 MW; CC3287A6933B1026 CRC64;
MSAINKVCVI GAGVMGASIA AHIANAGYPV LLLDIVPVAA KNRNIIAQTA IQKLLKSNPA
ALTHPRNAKL ITPLNIEDHL DQLSDCDWII EAIVERLDIK QELYKKLDQH RKSGSIVSSN
TSTIPLTSLA SGMSASFSED FCITHFFNPP RYMRLLEVVK GTDTRQSAID TVSEFADYKL
GKSIVNCKDR PGFIANRLGI FWIYCALVEA FDCGMSIEEA DAVLSRPCGV PKTGVFGLID
LVGLDLMPNI LQSMVSLLPE NDPFVQIERS LPLLEKMISD GYTGRKGKGG FYRINRDGGG
KVKEAIDLVS GEYRPVLKVE SQCAKIKVKD IRQLFETNDK SAKYAWRVMS QTLAYAASLV
ADAAEDITAI DEAMRLGYNW KFGPFKLLDI LGPQWFIEKL EQQNQVVPPI LQKLSGKSFY
REQEQKLQYF TSTGNYRDLQ RPSGILMLAD IKRRSQPILK NASAALWDIG DGVACFEFTS
KMNSLDSDTM QLLQKSILTV SKSYAALVIY TDANNFSAGA NLGLAMFAAN IAAWPEIAKI
VAAGQQAYKA LKYSPFPVVS APCGMALGGG CEILLHCDAV QAHIETYTGL VEVGVGLVPA
WGGCKEMLHR WSTNPKHPRG PMPGPAKAFE LISTATVSKS AEEARSNMVL RDTDGITMNR
YRLLSDAKQK ALSLVADYQA PQAPTFHLPG PSAKAAFTMA VDGFVRSGKA TKHDRVVSMA
VADILSGGAK ADPTVEQSED EILALERKTF MKIIRHPDSL ERVEHILLTS KPLRN
//